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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47093/2218-7332.2025.1210</article-id><article-id custom-type="elpub" pub-id-type="custom">sechenov-1210</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROSURGERY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕЙРОХИРУРГИЯ</subject></subj-group></article-categories><title-group><article-title>Microsurgical removal of a cavernous malformation on the midbrain dorsal surface using the supracerebellar infratentorial approach: a clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Микрохирургическое удаление кавернозной мальформации дорсальной поверхности среднего мозга путем супрацеребеллярного инфратенториального доступа: клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8471-1808</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахимов</surname><given-names>Н. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Rahimov</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рахимов Нарзулло Одинаевич, канд. мед. наук, доцент кафедры нейрохирургии и сочетанной травмы; врач-нейрохирург </p><p>пр-т Сино, ул. Сино, д. 29–31, г. Душанбе, 734003,</p><p>пр-т И. Сомони, д. 59, г. Душанбе, 734026</p></bio><bio xml:lang="en"><p>Narzullo O. Rahimov, Cand. of Sci. (Medicine), Associate Professor, Department of Neurosurgery and Combined Trauma; neurosurgeon of the Department of Neurosurgery</p><p>29–31, Sino Ave., Sino str., Dushanbe, 734003, </p><p>59, I. Somoni Ave., Dushanbe, 734026</p></bio><email xlink:type="simple">narzullorahimov91@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6782-2979</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахмонов</surname><given-names>Х. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakhmonov</surname><given-names>K. J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рахмонов Хуршед Джамшедович, д-р мед. наук, профессор кафедры нейрохирургии и сочетанной травмы; директор</p><p>пр-т Сино, ул. Сино, д. 29–31, г. Душанбе, 734003, </p><p>пр-т И. Сомони, д. 59, г. Душанбе, 734026</p></bio><bio xml:lang="en"><p>Khurshed J. Rakhmonov, Dr. of Sci. (Medicine), Professor, Department of Neurosurgery and Combined Trauma; Director</p><p>29–31, Sino Ave., Sino str., Dushanbe, 734003, </p><p>59, I. Somoni Ave., Dushanbe, 734026</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4311-3094</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сангинов</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sanginov</surname><given-names>D. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сангинов Джумабой Рахматович, д-р мед. наук, профессор кафедры онкологии </p><p>пр-т Сино, ул. Сино, д. 29–31, г. Душанбе, 734003</p></bio><bio xml:lang="en"><p>Dzhumaboy R. Sanginov, Dr. of Sci. (Medicine), Professor, Department of Oncology</p><p>29–31, Sino Ave., Sino str., Dushanbe, 734003</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-3352-0824</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хасанов Мухамадраджаб Амридинович, ординатор кафедры нейрохирургии и сочетанной травмы</p><p>пр-т Сино, ул. Сино, д. 29–31, г. Душанбе, 734003</p></bio><bio xml:lang="en"><p>Mukhamadrajab A. Khasanov, resident, Department of Neurosurgery and Combined Trauma</p><p>29–31, Sino Ave., Sino str., Dushanbe, 734003</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ «Таджикский государственный медицинский университет имени Абуали ибни Сино»; &#13;
ГУ «Национальный медицинский центр Республики Таджикистан Шифобахш»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>Avicenna Tajik State Medical University; &#13;
SI National Medical Center of Republic of Tajikistan “Shifobakhsh”</institution><country>Tajikistan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГОУ «Таджикский государственный медицинский университет имени Абуали ибни Сино»;&#13;
ГУ «Национальный медицинский центр Республики Таджикистан Шифобахш»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>Avicenna Tajik State Medical University; &#13;
SI National Medical Center of Republic of Tajikistan “Shifobakhsh”</institution><country>Tajikistan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГОУ «Таджикский государственный медицинский университет имени Абуали ибни Сино»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>Avicenna Tajik State Medical University</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2025</year></pub-date><volume>16</volume><issue>3</issue><fpage>31</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Rahimov N.O., Rakhmonov K.J., Sanginov D.R., Khasanov M.A., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Рахимов Н.О., Рахмонов Х.Д., Сангинов Д.Р., Хасанов М.А.</copyright-holder><copyright-holder xml:lang="en">Rahimov N.O., Rakhmonov K.J., Sanginov D.R., Khasanov M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/1210">https://www.sechenovmedj.com/jour/article/view/1210</self-uri><abstract><p>Common surgical approaches to the dorsal midbrain include: the occipital transtentorial, supracerebellar infratentorial, posterior subtemporal, and the tonsilloveal transaqueductal approaches.</p><sec><title>Case report</title><p>Case report. A 38-year-old man presented with mild right-sided weakness and diplopia following an episode of headache and vomiting two weeks prior to admission. A neurological examination revealed mild right-sided weakness, a downward and outward strabismus, a mild left ocular mydriasis and accommodation paralysis alongside alternating syndrome. Magnetic resonance imaging revealed a 20×30×25 mm rupture of the cavernous malformation of the left midbrain peduncle as well as hematomas within the cavernoma. Using the supracerebellar infratentorial approach in a sitting position with minimal incision of dorsal midbrain, the cavernoma was completely resected together with surrounding subacute hematoma. In the early postoperative period, a regression of neurological symptoms was observed.</p></sec><sec><title>Discussion</title><p>Discussion. The choice of median suboccipital craniotomy and contralateral supracerebellar infratentorial approach is the preferred route for complete resection of cavernoma of dorsal midbrain surface in order to avoid any postoperative neurological deficit.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Известные хирургические доступы к дорсальной части среднего мозга включают: затылочный транстенториальный, супрацеребеллярный инфратенториальный, задний субтемпоральный и тонзиллоувеальный трансакведуктальный подходы.</p><sec><title>Описание случая</title><p>Описание случая. 38-летний мужчина обратился с жалобами на легкую правостороннюю слабость и диплопию после эпизода головной боли и рвоты за две недели до поступления. В неврологическом статусе выявлено незначительное снижение мышечной силы с правой стороны, косоглазие вниз и наружу, легкий мидриаз и паралич аккомодации левого глаза, альтернирующий синдром. С помощью магнитно-резонансной томографии выявлен разрыв кавернозной мальформации размером 20×30×25 мм левой ножки среднего мозга, гематомы в каверноме. Путем супрацеребеллярного инфратенториального доступа в положении сидя с минимальным разрезом дорсальной части среднего мозга кавернома была полностью резецирована вместе с окружающей подострой гематомой. В раннем послеоперационном периоде наблюдался регресс неврологической симптоматики.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Выбор медианной субокципитальной краниотомии и контралатерального супрацеребеллярного инфратенториального доступа является предпочтительным для полной резекции каверномы дорсальной поверхности среднего мозга во избежание послеоперационного неврологического дефицита.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>кавернома</kwd><kwd>поражение ножек среднего мозга</kwd><kwd>доступ к дорсальной части среднего мозга</kwd><kwd>гематома</kwd><kwd>удаление образований среднего мозга</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cavernoma</kwd><kwd>lesion of the midbrain peduncles</kwd><kwd>access to the dorsal part of the midbrain</kwd><kwd>hematoma</kwd><kwd>removal of midbrain formations</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Snellings D.A., Hong C.C., Ren A.A., et al. Cerebral Cavernous Malformation: From Mechanism to Therapy. Circ Res. 2021 Jun 25; 129(1): 195–215. https://doi.org/10.1161/CIRCRESAHA.121.318174. Epub 2021 Jun 24. Erratum in: Circ Res. 2021 Aug 6; 129(4): e101. https://doi.org/10.1161/RES.0000000000000496. PMID: 34166073</mixed-citation><mixed-citation xml:lang="en">S1. Snellings D.A., Hong C.C., Ren A.A., et al. Cerebral Cavernous Malformation: From Mechanism to Therapy. Circ Res. 2021 Jun 25; 129(1): 195–215. https://doi.org/10.1161/CIRCRESAHA.121.318174. Epub 2021 Jun 24. Erratum in: Circ Res. 2021 Aug 6; 129(4): e101. https://doi.org/10.1161/RES.0000000000000496. PMID: 34166073</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tu T., Peng Z., Ren J., Zhang H. Cerebral Cavernous Malformation: Immune and Inflammatory Perspectives. Front Immunol. 2022 Jun 30; 13: 922281. https://doi.org/10.3389/fimmu.2022.922281. PMID: 35844490</mixed-citation><mixed-citation xml:lang="en">Tu T., Peng Z., Ren J., Zhang H. Cerebral Cavernous Malformation: Immune and Inflammatory Perspectives. Front Immunol. 2022 Jun 30; 13: 922281. https://doi.org/10.3389/fimmu.2022.922281. PMID: 35844490</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia R.M., Ivan M.E., Lawton M.T. Brainstem cavernous malformations: surgical results in 104 patients and a proposed grading system to predict neurological outcomes. Neurosurgery. 2015 Mar; 76(3): 265-277; discussion 277–278. https://doi.org/10.1227/NEU.0000000000000602. PMID: 25599905</mixed-citation><mixed-citation xml:lang="en">Garcia R.M., Ivan M.E., Lawton M.T. Brainstem cavernous malformations: surgical results in 104 patients and a proposed grading system to predict neurological outcomes. Neurosurgery. 2015 Mar; 76(3): 265-277; discussion 277–278. https://doi.org/10.1227/NEU.0000000000000602. PMID: 25599905</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Deshmukh V.R., Rangel-Castilla L., Spetzler R.F. Lateral inferior cerebellar peduncle approach to dorsolateral medullary cavernous malformation. J Neurosurg. 2014 Sep; 121(3): 723–729. https://doi.org/10.3171/2014.5.JNS132276. Epub 2014 Jun 27. PMID: 24972129</mixed-citation><mixed-citation xml:lang="en">Deshmukh V.R., Rangel-Castilla L., Spetzler R.F. Lateral inferior cerebellar peduncle approach to dorsolateral medullary cavernous malformation. J Neurosurg. 2014 Sep; 121(3): 723–729. https://doi.org/10.3171/2014.5.JNS132276. Epub 2014 Jun 27. PMID: 24972129</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">de Oliveira J.G., Lekovic G.P., Safavi-Abbasi S., et al. Supracerebellar infratentorial approach to cavernous malformations of the brainstem: surgical variants and clinical experience with 45 patients. Neurosurgery. 2010 Feb; 66(2): 389–399. https://doi.org/10.1227/01.NEU.0000363702.67016.5D. PMID: 20042987</mixed-citation><mixed-citation xml:lang="en">de Oliveira J.G., Lekovic G.P., Safavi-Abbasi S., et al. Supracerebellar infratentorial approach to cavernous malformations of the brainstem: surgical variants and clinical experience with 45 patients. Neurosurgery. 2010 Feb; 66(2): 389–399. https://doi.org/10.1227/01.NEU.0000363702.67016.5D. PMID: 20042987</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hong T., Xiao X., Ren J., et al. Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. Brain. 2021 Oct 22; 144(9): 2648–2658. https://doi.org/10.1093/brain/awab117. PMID: 33729480</mixed-citation><mixed-citation xml:lang="en">Hong T., Xiao X., Ren J., et al. Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. Brain. 2021 Oct 22; 144(9): 2648–2658. https://doi.org/10.1093/brain/awab117. PMID: 33729480</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rustenhoven J., Tanumihardja C., Kipnis J. Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow. Circ Res. 2021 Jun 25; 129(1): 174–194. https://doi.org/10.1161/CIRCRESAHA.121.318173. Epub 2021 Jun 24. PMID: 34166075</mixed-citation><mixed-citation xml:lang="en">Rustenhoven J., Tanumihardja C., Kipnis J. Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow. Circ Res. 2021 Jun 25; 129(1): 174–194. https://doi.org/10.1161/CIRCRESAHA.121.318173. Epub 2021 Jun 24. PMID: 34166075</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jong-A-Liem G.S., Martins Sarti T.H., Fernandes Lima J.V., et al. Midbrain Cavernous Malformation: Microsurgical Nuances and an Anatomoclinical Review 2-Dimensional Video. World Neurosurg. 2024 Nov; 191: 23–24. https://doi.org/10.1016/j.wneu.2024.07.213. Epub 2024 Aug 8. PMID: 39122114</mixed-citation><mixed-citation xml:lang="en">Jong-A-Liem G.S., Martins Sarti T.H., Fernandes Lima J.V., et al. Midbrain Cavernous Malformation: Microsurgical Nuances and an Anatomoclinical Review 2-Dimensional Video. World Neurosurg. 2024 Nov; 191: 23–24. https://doi.org/10.1016/j.wneu.2024.07.213. Epub 2024 Aug 8. PMID: 39122114</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kurihara N., Suzuki H., Kato Y., et al. Hemorrhage owing to cerebral cavernous malformation: imaging, clinical, and histopathological considerations. Jpn J Radiol. 2020 Jul; 38(7): 613–621. https://doi.org/10.1007/s11604-020-00949-x. Epub 2020 Mar 27. PMID: 32221793</mixed-citation><mixed-citation xml:lang="en">Kurihara N., Suzuki H., Kato Y., et al. Hemorrhage owing to cerebral cavernous malformation: imaging, clinical, and histopathological considerations. Jpn J Radiol. 2020 Jul; 38(7): 613–621. https://doi.org/10.1007/s11604-020-00949-x. Epub 2020 Mar 27. PMID: 32221793</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Joseph N.K., Kumar S., Brown R.D. Jr., et al. Influence of Pregnancy on Hemorrhage Risk in Women With Cerebral and Spinal Cavernous Malformations. Stroke. 2021 Jan; 52(2): 434– 441. https://doi.org/10.1161/STROKEAHA.120.031761. Epub 2021 Jan 25. PMID: 33493052</mixed-citation><mixed-citation xml:lang="en">Joseph N.K., Kumar S., Brown R.D. Jr., et al. Influence of Pregnancy on Hemorrhage Risk in Women With Cerebral and Spinal Cavernous Malformations. Stroke. 2021 Jan; 52(2): 434– 441. https://doi.org/10.1161/STROKEAHA.120.031761. Epub 2021 Jan 25. PMID: 33493052</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Spetzler R.F., Martin N.A. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986 Oct; 65(4): 476–483. https://doi.org/10.3171/jns.1986.65.4.0476. PMID: 3760956</mixed-citation><mixed-citation xml:lang="en">Spetzler R.F., Martin N.A. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986 Oct; 65(4): 476–483. https://doi.org/10.3171/jns.1986.65.4.0476. PMID: 3760956</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lawton M.T., Kim H., McCulloch C.E. et al. A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery. Neurosurgery. 2010 Apr; 66(4): 702–713; discussion 713. https://doi.org/10.1227/01.NEU.0000367555.16733. E1. PMID: 20190666</mixed-citation><mixed-citation xml:lang="en">Lawton M.T., Kim H., McCulloch C.E. et al. A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery. Neurosurgery. 2010 Apr; 66(4): 702–713; discussion 713. https://doi.org/10.1227/01.NEU.0000367555.16733. E1. PMID: 20190666</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Negoto T., Terachi S., Baba Y., et al. Symptomatic Brainstem Cavernoma of Elderly Patients: Timing and Strategy of Surgical Treatment. Two Case Reports and Review of the Literature. World Neurosurg. 2018 Mar; 111: 227–234. https://doi.org/10.1016/j.wneu.2017.12.111. Epub 2017 Dec 27. PMID: 29288846</mixed-citation><mixed-citation xml:lang="en">Negoto T., Terachi S., Baba Y., et al. Symptomatic Brainstem Cavernoma of Elderly Patients: Timing and Strategy of Surgical Treatment. Two Case Reports and Review of the Literature. World Neurosurg. 2018 Mar; 111: 227–234. https://doi.org/10.1016/j.wneu.2017.12.111. Epub 2017 Dec 27. PMID: 29288846</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Phi J.H., Kim S.K. Clinical Features and Treatment of Pediatric Cerebral Cavernous Malformations. J Korean Neurosurg Soc. 2024 May; 67(3): 299–307. https://doi.org/10.3340/jkns.2024.0047. Epub 2024 Mar 28. Erratum in: J Korean Neurosurg Soc. 2024 Jul; 67(4): 486. https://doi.org/10.3340/jkns.2024.0047.e1. PMID: 38547881</mixed-citation><mixed-citation xml:lang="en">Phi J.H., Kim S.K. Clinical Features and Treatment of Pediatric Cerebral Cavernous Malformations. J Korean Neurosurg Soc. 2024 May; 67(3): 299–307. https://doi.org/10.3340/jkns.2024.0047. Epub 2024 Mar 28. Erratum in: J Korean Neurosurg Soc. 2024 Jul; 67(4): 486. https://doi.org/10.3340/jkns.2024.0047.e1. PMID: 38547881</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ma L., Zhang S., Li Z.,, et al. Morbidity After Symptomatic Hemorrhage of Cerebral Cavernous Malformation: A Nomogram Approach to Risk Assessment. Stroke. 2020 Oct; 51(10): 2997– 3006. https://doi.org/10.1161/STROKEAHA.120.029942. Epub 2020 Sep 21. PMID: 32951540</mixed-citation><mixed-citation xml:lang="en">Ma L., Zhang S., Li Z.,, et al. Morbidity After Symptomatic Hemorrhage of Cerebral Cavernous Malformation: A Nomogram Approach to Risk Assessment. Stroke. 2020 Oct; 51(10): 2997– 3006. https://doi.org/10.1161/STROKEAHA.120.029942. Epub 2020 Sep 21. PMID: 32951540</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
