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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47093/2218-7332.2025.16.4.41-48</article-id><article-id custom-type="elpub" pub-id-type="custom">sechenov-1459</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SURGERY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИРУРГИЯ</subject></subj-group></article-categories><title-group><article-title>Management of a massive retrosternal goiter after prior thyroid surgery: a clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Стратегия лечения массивного ретростернального зоба после ранее перенесенной операции на щитовидной железе: клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-7821-4012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сетьо</surname><given-names>Д. Д.Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Setyo</surname><given-names>D. D.T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сетьо Дидик Дармади Три, врач-интерн хирургического профиля кафедры хирургии головы и шеи медицинского факультета </p><p>ул. Мейджен проф. д-ра Мустопо, д. 47, г. Сурабая, 60131</p></bio><bio xml:lang="en"><p>Didiek D.T. Setyo, surgical intern, Department of Head and Neck Surgery, Faculty of Medicine</p><p>47, Jl. Mayjen Prof. Dr. Moestopo, Surabaya, 60131</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-7108-6052</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидхарта</surname><given-names>И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidharta</surname><given-names>I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сидхарта Иван, доцент кафедры хирургии головы и шеи медицинского факультета университета </p><p>ул. Мейджен проф. д-ра Мустопо, д. 47, г. Сурабая, 60131</p></bio><bio xml:lang="en"><p>Iwan Sidharta, Associate Professor, Department of Head and Neck Surgery, Faculty of Medicine</p><p>47, Jl. Mayjen Prof. Dr. Moestopo, Surabaya, 60131</p></bio><email xlink:type="simple">iwansidh@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Университет Айрлангга, Региональная больница общего профиля имени доктора Сутомо</institution><country>Индонезия</country></aff><aff xml:lang="en"><institution>Airlangga University, Dr. Soetomo Regional General Hospital</institution><country>Indonesia</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2025</year></pub-date><volume>16</volume><issue>4</issue><fpage>41</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Setyo D.D., Sidharta I., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сетьо Д.Д., Сидхарта И.</copyright-holder><copyright-holder xml:lang="en">Setyo D.D., Sidharta I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/1459">https://www.sechenovmedj.com/jour/article/view/1459</self-uri><abstract><p>Adenomatous goiter is a common benign thyroid condition that can become surgically challenging when it extends into the mediastinum, including in patients with a history of partial thyroid surgery. Retrosternal goiter is often diagnosed at a late stage, and its management is frequently complex due to distorted mediastinal anatomy.</p><sec><title>Case report</title><p>Case report. A 58-year-old woman with a history of left isthmolobectomy performed in 2006 presented with a rapidly enlarging right-sided neck mass accompanied by dysphagia. Although the cervical findings initially suggested right thyroid lobe involvement, contrast-enhanced computed tomography revealed a massive retrosternal goiter originating from residual left thyroid tissue. The lesion extended retrosternally into the anterior mediastinum, resulting in significant tracheal narrowing, displacement of the esophagus, and close anatomical relationships with major mediastinal vessels. Management was undertaken by a multidisciplinary team, and the patient underwent complete thyroidectomy using a combined transcervical approach and median sternotomy, achieving complete resection of the retrosternal component.</p></sec><sec><title>Discussion</title><p>Discussion. This case highlights delayed retrosternal progression of adenomatous goiter after partial thyroid surgery. Cross-sectional imaging guided surgical planning, and median sternotomy enabled safe complete resection, underscoring the importance of long-term follow-up and multidisciplinary management.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Аденоматозный зоб является распространенным доброкачественным заболеванием щитовидной железы, которое может представлять значительные хирургические трудности при распространении в средостение, в том числе у пациентов с анамнезом частичной тиреоидэктомии. Ретростернальный зоб часто выявляется на поздних стадиях, а его лечение нередко осложняется измененной анатомией шеи и средостения.</p><sec><title>Клинический случай</title><p>Клинический случай. Пациентка 58 лет с анамнезом удаления левой доли щитовидной железы и перешейка, выполненной в 2006 году, обратилась по поводу быстро увеличивающегося правостороннего образования шеи, сопровождающегося дисфагией. Клинические данные указывали на вовлечение правой доли щитовидной железы, вместе с тем по данным компьютерной томографии с контрастированием выявлен массивный ретростернальный зоб, исходящий из остаточной ткани левой доли. Образование распространялось ретростернально в переднее средостение, вызывая выраженное сужение трахеи, смещение пищевода, и находилось вблизи магистральных сосудов средостения. Мультидисциплинарной командой пациентке была выполнена тотальная тиреоидэктомия с использованием комбинированного шейного доступа и медианной стернотомии, что позволило добиться полного удаления ретростернального компонента.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Представленный клинический случай демонстрирует отсроченное ретростернальное распространение аденоматозного зоба после частичной тиреоидэктомии. Методы лучевой диагностики сыграли ключевую роль в планировании хирургического вмешательства, а медианная стернотомия обеспечила безопасное и радикальное удаление образования, что подчеркивает необходимость длительного наблюдения и мультидисциплинарного подхода к ведению таких пациентов.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>аденоматозный зоб</kwd><kwd>тиреоидэктомия</kwd><kwd>стернотомия</kwd><kwd>рецидивирующий случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adenomatous goiter</kwd><kwd>thyroidectomy</kwd><kwd>sternotomy</kwd><kwd>recurrent case</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки (собственные ресурсы).</funding-statement><funding-statement xml:lang="en">The study was not sponsored (own resources).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yankov G., Alexieva M., Mekov E.V. Residual retrosternal goiter and thymolipoma after cervical thyroid resection. Cureus. 2024 Oct; 16(10): e71627. https://doi.org/10.7759/cureus.71627. PMID: 39553011</mixed-citation><mixed-citation xml:lang="en">Yankov G., Alexieva M., Mekov E.V. Residual retrosternal goiter and thymolipoma after cervical thyroid resection. Cureus. 2024 Oct; 16(10): e71627. https://doi.org/10.7759/cureus.71627. PMID: 39553011</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gurrado A., Prete F.P., Di Meo G., et al. Retrosternal, forgotten, and recurrent goiter. In: Testini M., Gurrado A., editors. Thyroid Surgery. Updates in Surgery. Cham: Springer; 2024. P. 39–46. https://doi.org/10.1007/978-3-031-31146-8_5</mixed-citation><mixed-citation xml:lang="en">Gurrado A., Prete F.P., Di Meo G., et al. Retrosternal, forgotten, and recurrent goiter. In: Testini M., Gurrado A., editors. Thyroid Surgery. Updates in Surgery. Cham: Springer; 2024. P. 39–46. https://doi.org/10.1007/978-3-031-31146-8_5</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cappellacci F., Canu G.L., Rossi L., et al. Differences in surgical outcomes between cervical goiter and retrosternal goiter: an international, multicentric evaluation. Front Surg. 2024 Feb; 11: 1341683. https://doi.org/10.3389/fsurg.2024.1341683. PMID: 38379818</mixed-citation><mixed-citation xml:lang="en">Cappellacci F., Canu G.L., Rossi L., et al. Differences in surgical outcomes between cervical goiter and retrosternal goiter: an international, multicentric evaluation. Front Surg. 2024 Feb; 11: 1341683. https://doi.org/10.3389/fsurg.2024.1341683. PMID: 38379818</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Akinci O., Aygan S., Inci E., et al. Computed tomography findings affecting the decision of sternotomy in substernal goiter. Sisli Etfal Hastan Tip Bul. 2023 Sep; 57(3): 305–311. https://doi.org/10.14744/SEMB.2023.25307. PMID: 37900343</mixed-citation><mixed-citation xml:lang="en">Akinci O., Aygan S., Inci E., et al. Computed tomography findings affecting the decision of sternotomy in substernal goiter. Sisli Etfal Hastan Tip Bul. 2023 Sep; 57(3): 305–311. https://doi.org/10.14744/SEMB.2023.25307. PMID: 37900343</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sahbaz A., Aksakal N., Ozcinar B., et al. The “forgotten” goiter after total thyroidectomy. Int J Surg Case Rep. 2013; 4(3): 269– 271. https://doi.org/10.1016/j.ijscr.2012.11.014. Epub 2012 Dec 7. PMID: 23336990</mixed-citation><mixed-citation xml:lang="en">Sahbaz A., Aksakal N., Ozcinar B., et al. The “forgotten” goiter after total thyroidectomy. Int J Surg Case Rep. 2013; 4(3): 269– 271. https://doi.org/10.1016/j.ijscr.2012.11.014. Epub 2012 Dec 7. PMID: 23336990</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Prete F.P., De Luca G.M., Sgaramella L.I., et al. Prevalence and clinical risk factors of thyroid cancer in retrosternal goiter: a retrospective comparative study with cervical multinodular goiter. J Clin Med. 2025 Jan; 14(2): 489. https://doi.org/10.3390/jcm14020489. PMID: 39860494</mixed-citation><mixed-citation xml:lang="en">Prete F.P., De Luca G.M., Sgaramella L.I., et al. Prevalence and clinical risk factors of thyroid cancer in retrosternal goiter: a retrospective comparative study with cervical multinodular goiter. J Clin Med. 2025 Jan; 14(2): 489. https://doi.org/10.3390/jcm14020489. PMID: 39860494</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mukhtar H., Zahid H., Khan I.M., et al. A new metric classification system for surgical management of retrosternal goitres. J Coll Physicians Surg Pak. 2025 Jun; 35(6): 708–711. https://doi.org/10.29271/jcpsp.2025.06.708. PMID: 40491102</mixed-citation><mixed-citation xml:lang="en">Mukhtar H., Zahid H., Khan I.M., et al. A new metric classification system for surgical management of retrosternal goitres. J Coll Physicians Surg Pak. 2025 Jun; 35(6): 708–711. https://doi.org/10.29271/jcpsp.2025.06.708. PMID: 40491102</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tessler F.N., Middleton W.D., Grant E.G., et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. J Am Coll Radiol. 2017 May; 14(5): 587–595. https://doi.org/10.1016/j.jacr.2017.01.046. Epub 2017 Apr 2. PMID: 28372962</mixed-citation><mixed-citation xml:lang="en">Tessler F.N., Middleton W.D., Grant E.G., et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. J Am Coll Radiol. 2017 May; 14(5): 587–595. https://doi.org/10.1016/j.jacr.2017.01.046. Epub 2017 Apr 2. PMID: 28372962</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Obadiel Y.A., Al-Shehari M., Algmaly Y., et al. Surgical Management and Predictors of Postoperative Complications of Retrosternal Goiters: A Retrospective Study. Cureus. 2024 Mar; 16(3): e56573. https://doi.org/10.7759/cureus.56573. PMID: 38646310</mixed-citation><mixed-citation xml:lang="en">Obadiel Y.A., Al-Shehari M., Algmaly Y., et al. Surgical Management and Predictors of Postoperative Complications of Retrosternal Goiters: A Retrospective Study. Cureus. 2024 Mar; 16(3): e56573. https://doi.org/10.7759/cureus.56573. PMID: 38646310</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sridar K., Mohiyuddin S.A., A S., et al. Outcomes of total thyroidectomy in large goiters with retrosternal extension and tracheal compression: a multivariate analysis. Cureus. 2024 Nov; 16(11): e73921. https://doi.org/10.7759/cureus.73921. PMID: 39697941</mixed-citation><mixed-citation xml:lang="en">Sridar K., Mohiyuddin S.A., A S., et al. Outcomes of total thyroidectomy in large goiters with retrosternal extension and tracheal compression: a multivariate analysis. Cureus. 2024 Nov; 16(11): e73921. https://doi.org/10.7759/cureus.73921. PMID: 39697941</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Q., Su A., Zou X., et al. Clinicopathologic characteristics and outcomes of massive multinodular goiter: a retrospective cohort study. Front Endocrinol. 2022 May; 13: 850235. https://doi.org/10.3389/fendo.2022.850235. PMID: 35685217</mixed-citation><mixed-citation xml:lang="en">Chen Q., Su A., Zou X., et al. Clinicopathologic characteristics and outcomes of massive multinodular goiter: a retrospective cohort study. Front Endocrinol. 2022 May; 13: 850235. https://doi.org/10.3389/fendo.2022.850235. PMID: 35685217</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Al Jadeedi S., Usama M., Al Harthi H., et al. A hybrid surgical approach for retrosternal goiter: surgical experience at a tertiary thoracic and endocrine surgery center. J Endocr Surg. 2025 Sep; 25(3): 89-100. https://doi.org/10.16956/jes.2025.25.3.89</mixed-citation><mixed-citation xml:lang="en">Al Jadeedi S., Usama M., Al Harthi H., et al. A hybrid surgical approach for retrosternal goiter: surgical experience at a tertiary thoracic and endocrine surgery center. J Endocr Surg. 2025 Sep; 25(3): 89-100. https://doi.org/10.16956/jes.2025.25.3.89</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
