sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университет10.47093/2218-7332.2020.11.1.59-70sechenov-168Research ArticleSURGERYХИРУРГИЯBioresorbable collagen materials in surgery: 50 years of successБиорезорбируемые коллагеновые материалы в хирургии: 50 лет успехаhttps://orcid.org/0000-0003-4137-8993ФайзуллинА. Л.FayzullinA. L.

Файзуллин Алексей Леонидович, младший научный сотрудник Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991+7 (917) 587-88-31 

Alexey L. Fayzullin, Junior research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991Tel.: +7 (917) 587-88-31 

fayzullin_a_l@staff.sechenov.ruhttps://orcid.org/0000-0003-3220-9442ШехтерА. Б.ShekhterA. B.

Шехтер Анатолий Борисович, д-р мед. наук, профессор, заведующий Лабораторией экспериментальной морфологии Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Anatoly B. Shekhter, Professor, MD, PhD, DMSc, Head of the Laboratory of experimental morphology, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

shekhter_a_b@staff.sechenov.ruhttps://orcid.org/0000-0001-6209-0441ИстрановЛ. П.IstranovL. P.

Истранов Леонид Прокофьевич, д-р фарм. наук, профессор, главный научный сотрудник Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Leonid P. Istranov, Professor, PhD, DSc, Principal research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

istranov_l_p@staff.sechenov.ruhttps://orcid.org/0000-0001-5433-9884ИстрановаЕ. В.IstranovaE. V.

Истранова Елена Викторовна, канд. фарм. наук, ведущий научный сотрудник Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Elena V. Istranova, PhD, Leading research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

istranova_e_v@staff.sechenov.ruhttps://orcid.org/0000-0002-1296-4494РуденкоТ. Г.RudenkoT. G.

Руденко Татьяна Георгиевна, канд. мед. наук, ведущий научный сотрудник Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Tatyana G. Rudenko, MD, PhD, Leading research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

rudenko_t_g@staff.sechenov.ruhttps://orcid.org/0000-0002-8866-9838ГуллерА. Е.GullerA. E.

Гуллер Анна Евгеньевна, старший научный сотрудник Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Anna E. Guller, PhD, Senior research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

guller_a_e@staff.sechenov.ruhttps://orcid.org/0000-0002-2531-4095АбоянцР. К.AboyantsR. K.

Абоянц Рубен Карапетович, канд. мед. наук, инженер Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Ruben K. Aboyants, MD, PhD, engineer, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

aboyants_r_k@staff.sechenov.ruhttps://orcid.org/0000-0001-7773-2435ТимашевП. С.TimashevP. S.

Тимашев Петр Сергеевич, д-р хим. наук, директор Института регенеративной медицины

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Petr S. Timashev, PhD, DSc, Director, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991

timashev_p_s@staff.sechenov.ruhttps://orcid.org/0000-0003-2173-0566БутнаруД. В.ButnaruD. V.

Бутнару Денис Викторович, канд. мед. наук, проректор по научной работе и общественным связям

ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991

Denis V. Butnaru, MD, PhD, Vice-rector for Research and Public Relations

8/2, Trubetskaya str., Moscow, 119991

butnaru_d_v@staff.sechenov.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation2020300320201115970Copyright © Fayzullin A.L., Shekhter A.B., Istranov L.P., Istranova E.V., Rudenko T.G., Guller A.E., Aboyants R.K., Timashev P.S., Butnaru D.V., 20202020Файзуллин А.Л., Шехтер А.Б., Истранов Л.П., Истранова Е.В., Руденко Т.Г., Гуллер А.Е., Абоянц Р.К., Тимашев П.С., Бутнару Д.В.Fayzullin A.L., Shekhter A.B., Istranov L.P., Istranova E.V., Rudenko T.G., Guller A.E., Aboyants R.K., Timashev P.S., Butnaru D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/168

Collagen materials are widely applied in medicine due to optimal handling characteristics, biocompatibility, controlled biodegradation, the ability to form complexes with drugs and facilitate regeneration. Researchers from Sechenov University developed, studied in experiments and introduced into medicine a variety of materials based on collagen — a protein of connective tissue. At the same time, new collagen materials were launched into clinical practice abroad. In this review of Russian and world literature, we described how scientific and applied studies of collagen materials developed over time and tried to illustrate the current state and trends of collagen application for a variety of medical purposes — from hemostatic sponges to tissue-engineered constructs. The range of available collagen-based medical products and the emergence of new collagen materials indicate the keen interest in this biomaterial from the medical community and the potential of future discoveries.

Коллагеновые материалы широко применяются в медицине благодаря оптимальным манипуляционным характеристикам, биосовместимости, управляемой биодеградации, способности образовывать комплексы с лекарственными препаратами и стимулировать регенерацию. Отечественные ученые из Сеченовского Университета создали, изучили в эксперименте и внедрили в медицину разнообразные материалы из белка соединительной ткани — коллагена. Одновременно новые коллагеновые материалы внедрялись в клиническую практику за рубежом. В настоящем обзоре отечественной и мировой литературы мы описали, как развивались научно-прикладные исследования коллагеновых материалов, и постарались представить срез актуального состояния и тенденций применения коллагена в самых разных медицинских целях — от кровоостанавливающих губок до тканеинженерных конструкций. Разнообразие доступных медицинских продуктов на основе коллагена и появление новых коллагеновых изделий свидетельствуют о живом интересе к этому биоматериалу со стороны медицинского сообщества, а следовательно, и перспективности дальнейших исследований.

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The authors declare that there are no conflicts of interest present.