sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-21Research ArticleADVANCEMENTS IN FUNDAMENTAL SCIENCEДОСТИЖЕНИЯ ФУНДАМЕНТАЛЬНОЙ НАУКИSpectrofluorimetric antibiotic detection (Review)Спектрофлуориметрическое определение антибиотиков (Обзор)ЛеонтьевВ. Н.LeontievV. N.leontiev@belstu.byЛукьянчикП. Г.LukyanchykP. G.scorpion12top@mail.ruЛазовскаяО. И.LazovskayaO. I.lazovskaya@belstu.byУчреждение образования «Белорусский государственный технологический университет»РоссияBelarusian State Technological UniversityRussian FederationООО «Фармтехнология», БеларусьРоссияLLC “Pharmtechnology”Russian Federation201730062017025660Copyright © Leontiev V.N., Lukyanchyk P.G., Lazovskaya O.I., 20172017Леонтьев В.Н., Лукьянчик П.Г., Лазовская О.И.Leontiev V.N., Lukyanchyk P.G., Lazovskaya O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/21

The article discusses spectrofluorimetric detection of antibiotic drugs based on the intrinsic fluorescence of antibiotics, the formation of fluorescent products following the interaction of antibiotics with other compounds, and the application of the antibiotic-induced fluorescence quenching of specific dyes. Based on the literature data, the authors summarized and systematized information about parameters of antibiotic fluorescent analysis - the excitation and emission wavelengths, the reagent used and reaction conditions, the detection limit.

В статье рассмотрены основные направления спектрофлуориметрического определения антибиотических лекарственных средств - использование собственной флуоресценции антибиотиков, образование флуоресцирующих продуктов в результате взаимодействия антибиотиков с другими соединениями и применение эффекта тушения флуоресценции специфических красителей антибиотиками. На основании литературных данных авторами обобщена и систематизирована информация о параметрах флуоресцентного анализа различных антибиотиков - длины волн возбуждения и испускания, применяемый реагент и условия реакции, предел обнаружения.

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The authors declare that there are no conflicts of interest present.