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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47093/2218-7332.2020.11.2.92-98</article-id><article-id custom-type="elpub" pub-id-type="custom">sechenov-245</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COVID-19</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>COVID-19</subject></subj-group></article-categories><title-group><article-title>Isolated bitemporal hemianopia in a patient with COVID-19</article-title><trans-title-group xml:lang="ru"><trans-title>Изолированная битемпоральная гемианопсия у пациента с инфекцией COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5939-1032</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жаркова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zharkova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жаркова Мария Сергеевна, канд мед. наук, заведующая отделением гепатологии Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии имени В.Х. Василенко Университетской клинической больницы № 2 </p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p></bio><bio xml:lang="en"><p>Maria S. Zharkova, MD, PhD, Head of hepatology department, V. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology, University Clinical Hospital No. 2</p><p>8/2, Trubetskaya str., Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0532-9126</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонов</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonov</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тихонов Игорь Николаевич, ассистент кафедры пропедевтики внутренних болезней; врач-гастроэнтеролог отделения гепатологии Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии имени В.Х. Василенко Университетской клинической больницы № 2 </p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p></bio><bio xml:lang="en"><p>Igor N. Tikhonov, Assistant Professor, Department of Internal Disease Propedeutics; gastroenterologist of hepatology department, V. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology, University Clinical Hospital No. 2</p><p>8/2, Trubetskaya str., Moscow, 119991</p><p>+7 (917) 542-08-86</p></bio><email xlink:type="simple">antihbs@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4112-0426</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефремова Ирина Вячеславовна, аспирант кафедры пропедевтики внутренних болезней </p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p></bio><bio xml:lang="en"><p>Irina V. Efremova, postgraduate student, Department of Internal Disease Propedeutics</p><p>8/2, Trubetskaya str., Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1316-6929</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ондос</surname><given-names>Ш. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ondos</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ондос Шауки Ахмад, канд. мед. наук, врачгастроэнтеролог отделения гепатологии Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии имени В.Х. Василенко Университетской клинической больницы № 2 </p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p></bio><bio xml:lang="en"><p>Shauki А. Ondos, MD, PhD, gastroenterologist of hepatology department, V. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology, University Clinical Hospital No. 2</p><p>8/2, Trubetskaya str., Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1210-2528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Надинская</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nadinskaia</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Надинская Мария Юрьевна, канд. мед. наук, доцент кафедры пропедевтики внутренних болезней </p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p></bio><bio xml:lang="en"><p>Maria Yu. Nadinskaia, MD, PhD, Associate Professor, Department of Internal Disease Propedeutics</p><p>8/2, Trubetskaya str., Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6815-6015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивашкин</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivashkin</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивашкин Владимир Трофимович, д-р мед. наук, профессор, академик РАН, заведующий кафедрой пропедевтики внутренних болезней; директор Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии имени В.Х. Василенко Университетской клинической больницы №2</p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p></bio><bio xml:lang="en"><p>Vladimir T. Ivashkin, MD, PhD, DMSc, Professor, Academician of the RAS, Head of Department of Internal Diseases Propedeutics; Director of V. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology, University Clinical Hospital No. 2</p><p>8/2, Trubetskaya str., Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>06</day><month>12</month><year>2020</year></pub-date><volume>11</volume><issue>2</issue><issue-title>Special Issue: COVID-19</issue-title><fpage>92</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Zharkova M.S., Tikhonov I.N., Efremova I.V., Ondos S.A., Nadinskaia M.Y., Ivashkin V.T., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Жаркова М.С., Тихонов И.Н., Ефремова И.В., Ондос Ш.А., Надинская М.Ю., Ивашкин В.Т.</copyright-holder><copyright-holder xml:lang="en">Zharkova M.S., Tikhonov I.N., Efremova I.V., Ondos S.A., Nadinskaia M.Y., Ivashkin V.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/245">https://www.sechenovmedj.com/jour/article/view/245</self-uri><abstract><sec><title>Introduction</title><p>Introduction. Symptoms of lesions of the I, VII and IX pairs of cranial nerves during SARS-CoV-2 infection are observed in about a third of cases. Isolated bitemporal hemianopia as a symptom of optic nerve damage at the chiasmal level in patients with COVID-19 has not been described yet.</p></sec><sec><title>Case report</title><p> Case report. A 65-year-old man with a history of arterial hypertension and myocardial infarction and confirmed COVID-19 infection with severe lung damage on computed tomography. Patient developed bitemporal hemianopia, confirmed by the Donders test, on the second day of hospitalization. CT scan revealed no lesions and organic pathology in the parachiasmatic region and in the substance of the brain. Two days later, there was a complete restoration of lateral vision.</p></sec><sec><title>Discussion</title><p> Discussion. The most likely cause of bitemporal hemianopia was microthrombotic or inflammatory lesion at the chiasmal level. Risk factors for thrombotic complications: male gender, age 65, history of cardiovascular diseases, increased D-dimer levels, and signs of systemic inflammation (increased levels of C-reactive protein, fibrinogen, lactate dehydrogenase, and ferritin). An alternative hypothesis for the development of chiasmal syndrome may be direct viral invasion SARS-CoV-2 of the central nervous system.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Введение</title><p>Введение. Симптомы поражения I, VII и IX пар черепно-мозговых нервов при инфекции SARS-CoV-2 наблюдаются примерно в трети случаев. Изолированная битемпоральная гемианопсия как симптом поражения зрительного нерва на хиазмальном уровне у пациентов с COVID-19 до настоящего времени не описана.</p></sec><sec><title>Описание случая</title><p>Описание случая. У мужчины 65 лет с анамнезом артериальной гипертензии и перенесшего инфаркт диагностирован COVID-19 с тяжелой степенью поражения легких по компьютерной томографии (КТ). На вторые сутки в стационаре развилась битемпоральная гемианопсия, установленная по тесту Дондерса. КТ головного мозга не выявила органической патологии в парахиазмальной области и в веществе головного мозга. Боковое зрение полностью восстановилось через два дня.</p></sec><sec><title>Обсуждение</title><p> Обсуждение. Наиболее вероятной причиной битемпоральной гемианопсии служило микротромботическое или воспалительное поражение на хиазмальном уровне. Факторы риска тромботических осложнений: мужской пол, возраст, наличие сердечно-сосудистых заболеваний в анамнезе, повышение уровня D-димера; признаки системного воспаления: повышение С-реактивного белка, фибриногена, лактатдегидрогеназы, ферритина. Альтернативной гипотезой развития хиазмального синдрома может быть прямая вирусная инвазия SARS-CoV-2 в центральную нервную систему</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>битемпоральная гемианопсия</kwd><kwd>зрительный нерв</kwd><kwd>хиазма</kwd><kwd>неврит</kwd><kwd>хиазматит</kwd><kwd>COVID-19</kwd><kwd>SARSCoV-2</kwd><kwd>тест Дондерса</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bitemporal hemianopia</kwd><kwd>optic nerve</kwd><kwd>chiasma</kwd><kwd>neuritis</kwd><kwd>chiasmatitis</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>Donders test</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Peli E., Satgunam P. Bitemporal hemianopia; its unique binocular complexities and a novel remedy. Ophthalmic Physiol Opt. 2014; 34(2): 233-42. https://doi.org/10.1111/opo.12118 PMID: 24588535</mixed-citation><mixed-citation xml:lang="en">Peli E., Satgunam P. 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