sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университет10.47093/2218-7332.2021.293.03sechenov-351Research ArticleINTERNAL MEDICINEВНУТРЕННИЕ БОЛЕЗНИCurrent and novel theranostic modalities for knee osteoarthritisТрадиционные и новые методы лечения остеоартрита коленного сустава с использованием тераностического подходаhttps://orcid.org/0000-0002-1375-1052СадриБ.SadriB.

Садри Бахарех - M.Sc., кафедра инженерии и естественных наук, факультет новых наук и технологий.

Ул. Северный Каргар, г. Тегеран, 14399-57131

Bahareh Sadri - M.Sc., Department of Life Science Engineering, Faculty of New Sciences and Technologies.

North Kargar str., Tehran, 14399-57131

https://orcid.org/0000-0003-3423-1002НураиШ.NouraeinSh.

Садри Бахарех - M.Sc., кафедра инженерии и естественных наук, факультет новых наук и технологий.

Ул. Северный Каргар, г. Тегеран, 14399-57131

Shirin Nouraein - M.Sc., Department of Life Science Engineering, Faculty of New Sciences and Technologies.

North Kargar str., Tehran, 14399-57131

https://orcid.org/0000-0002-8950-2554Хуссейн-ХанназерН.Hossein-KhannazerN.

Хуссейн-Ханназер Нико - MD, PhD.

Корп. № 2, просп. Араби, бульвар Данешжу, Тегеран, 19839-63113

Nikoo Hossein-Khannazer - MD, PhD.

Bldg No. 2 SBUMS, Arabi Ave, Daneshjoo Blvd, Tehran, 19839-63113

https://orcid.org/0000-0002-5885-5402МохаммадиД.MohammadiJ.

Мохаммади Джавад - MD, PhD, кафедра инженерии и естественных наук, факультет новых наук и технологий.

Ул. Северный Каргар, г. Тегеран, 14399-57131

Javad Mohammadi - MD, PhD, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran.

North Kargar str., Tehran, 14399-57131, Iran 

https://orcid.org/0000-0001-5924-4366ВосоМ.VosoughM.

Восо Массуд - MD, PhD, отделение регенеративной медицины.

2-й переулок Хафез, Бани-Хашем, Тегеран, 16635-148, Тел.: +98-912-119-6454

Massoud Vosough - MD, PhD, Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology.

Nr. 2 Hafez Alley, Banihashem, Resalat, Tehran, 16635-148

araujojred@terra.com.brТегеранский УниверситетИранUniversity of TehranIslamic Republic of IranНаучный центр гастроэнтерологии и заболеваний печени, Научно-исследовательский институт гастроэнтерологии и заболеваний печени, Медицинский университет имени Шахида БехештиИранGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical SciencesIslamic Republic of IranНаучно-исследовательский центр цитологии, Роянский институт биологии и технологии стволовых клетокИранCell Science Research center, Royan Institute for Stem Cell Biology and TechnologyIslamic Republic of Iran2021141220211231730Copyright © Sadri B., Nouraein S., Hossein-Khannazer N., Mohammadi J., Vosough M., 20212021Садри Б., Нураи Ш., Хуссейн-Ханназер Н., Мохаммади Д., Восо М.Sadri B., Nouraein S., Hossein-Khannazer N., Mohammadi J., Vosough M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/351

 

Osteoarthritis is the second most common disorder after heart disease. This progressive degenerative disease affects the knee joint more than any others. The exact etiology of knee osteoarthritis is not clear, however, there are many predisposing factors such as obesity, age, gender, etc., that can increase the incidence and prevalence of this disease. Early diagnosis in knee osteoarthritis is very important. Despite the variety of diagnostic methods, lack of a valid and reliable diagnostic approach to detect the disorder in early stages has always been a challenge for researchers. Establishing an efficient therapeutic protocol for these patients is another crucial challenge. Recently, in addition to conventional treatments, which are surgical and non-surgical, tissue engineering and regenerative medicine as novel therapeutic modalities have received remarkable attention. In this paper, current diagnostic and therapeutic methods for knee osteoarthritis are discussed and potential biomarkers for early diagnosis and monitoring the clinical condition are discussed.

Остеоартрит - второе по распространенности заболевание после болезней сердечно-сосудистой системы. Это прогрессирующее дегенеративное заболевание поражает в большей степени коленный сустав. Точная этиология остеоартрита коленного сустава не ясна, однако существует множество предрасполагающих факторов, таких как ожирение, возраст, пол и другие, которые могут увеличить заболеваемость и распространенность этого заболевания. Очень важна ранняя диагностика остеоартрита коленного сустава. Несмотря на разнообразие диагностических методов, отсутствие надежного диагностического подхода для выявления расстройства на ранних стадиях всегда было проблемой для исследователей. Еще одной важной задачей является создание эффективного терапевтического протокола для этих пациентов. В последнее время, в дополнение к традиционным хирургическим и нехирургическим методам лечения, применяются методики тканевой инженерии и регенеративной медицины в качестве новых терапевтических методов, представляющих значительный интерес. В этой статье обсуждаются современные методы диагностики и лечения остеоартрита коленного сустава, а также обсуждаются потенциальные биомаркеры для ранней диагностики и мониторинга клинического состояния.

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The authors declare that there are no conflicts of interest present.