sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-45Research ArticleСтатьиINTERACTOMICS IN TRANSLATIONAL MEDICINEИНТЕРАКТОМИКА В ТРАНСЛЯЦИОННОЙ МЕДИЦИНЕГлуховА. И.GlukhovA. I.noemail@neicon.ruХучуаЗ. А.KhuchuaZ. A.noemail@neicon.ruГрызуноваГ. К.GrizunovaG. K.noemail@neicon.ruАстаховД. В.AstakhovD. V.noemail@neicon.ruДанилевскийМ. И.DanilevskiyM. I.noemail@neicon.ruФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияI.M. Sechenov First Moscow State Medical University; Lomonosov Moscow State UniversityRussian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); Детский медицинского исследовательского центраРоссияI.M. Sechenov First Moscow State Medical University; Cincinnati Childrenʼs Hospital and Medical CenterRussian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation20183003201801415Copyright © Glukhov A.I., Khuchua Z.A., Grizunova G.K., Astakhov D.V., Danilevskiy M.I., 20182018Глухов А.И., Хучуа З.А., Грызунова Г.К., Астахов Д.В., Данилевский М.И.Glukhov A.I., Khuchua Z.A., Grizunova G.K., Astakhov D.V., Danilevskiy M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/45

The article describes the place of interactomics in translational medicine. The approaches and methods used for the detection of protein-protein interactions and the construction of interactomes are described. Examples of electronic databases that work with interactomes are given, as well as examples of consortia of such databases. Examples of the use of interactomes for developing new approaches and methods of treatment of such diseases as cancer, diabetes, schizophrenia are considered. The main difficulties encountered in the construction of interactomes, and the prospects for the development of interactomics are outlined.

В статье обозначено место интерактомики в трансляционной медицине. Описаны подходы и методы, используемые для обнаружения межбелковых взаимодействий и построения интерактомов. Приведены примеры электронных баз данных, работающих с интерактомами, а также примеры консорциумов таких баз. Рассмотрены примеры использования интерактомов для разработки новых подходов и методов лечения таких заболеваний, как рак, диабет, шизофрения. Обозначены основные трудности, возникающие при построении интерактомов, и перспективы развития интерактомики.

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The authors declare that there are no conflicts of interest present.