sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-52Research ArticleСтатьиMODERN APPROACHES TO THE TREATMENT OF HEPATIC METASTASES FROM NEUROENDOCRINE TUMORS (LITERATURE REVIEW)СОВРЕМЕННЫЕ ПОДХОДЫ К ЛЕЧЕНИЮ МЕТАСТАЗОВ НЕЙРОЭНДОКРИННЫХ ОПУХОЛЕЙ В ПЕЧЕНИ (ОБЗОР ЛИТЕРАТУРЫ)ЧистяковаО. В.ChistyakovaO. V.noemail@neicon.ruСоловьеваО. Н.SolovyevaO. N.noemail@neicon.ruСяодунД.XiaodongD.dxdrexue@163.comКосыревВ. Ю.KosyrevV. Yu.noemail@neicon.ruФГБУ РОНЦ им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin Russian Cancer Reseach CenterRussian Federation115478, г. Москва, Каширское шоссе, д. 23РоссияI.M. Sechenov First Moscow State Medical UniversityRussian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation201830032018015459Copyright © Chistyakova O.V., Solovyeva O.N., Xiaodong D., Kosyrev V.Y., 20182018Чистякова О.В., Соловьева О.Н., Сяодун Д., Косырев В.Ю.Chistyakova O.V., Solovyeva O.N., Xiaodong D., Kosyrev V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/52

Originating from cells of the diffuse neuroendocrine system, neuroendocrine tumors are able to produce biogenic amines and peptide hormones. Due to the significantly different list of biologically active compounds and level of activity of secretory cells in tumor tissues, their clinical manifestations varies. Liver is one of the most frequent targeted organs for metastasizing this type of tumors, regardless of localization. After the patients being diagnosed, all the treatment measures are focused on two aspects. The first is to suppress the clinical symptoms and improve the living quality. The second one, an increase in life expectancy. Among all the potentially effectible treatments, surgical resection is the only one that may radically kill the disease. However, its application are limited in some cases. In this regard, in the strategy of therapeutic approaches of neuroendocrine tumors with metastases in the liver, a combination of medical, surgical and renal surgical methods comes to the fore.

Нейроэндокринные опухоли представляют собой крайне гетерогенную группу эпителиальных новообразований. Источником их происхождения являются клетки диффузной нейроэндокринной системы, вследствие чего они способны производить биогенные амины и пептидные гормоны. Перечень биологически активных соединений и уровень активности секреторных клеток в опухолевой ткани может существенно варьировать, что обуславливает различия в клинической картине заболевания. Одним из наиболее частых органов-мишеней для метастазирования данного вида опухолей вне зависимости от локализации является печень. После постановки диагноза, лечение нацелено на 2 направления: первое - это подавление симптомов и улучшение качества жизни пациента; второе - увеличение продолжительности жизни. Среди разнообразных способов лечения, хирургическое удаление опухоли - это единственный метод, способный радикально избавить от болезни, но его применение возможно далеко не во всех случаях. В связи с этим, в стратегии лечебных подходов нейроэндокринных опухолей с метастазами в печени на первый план выходит сочетание медикаментозных, хирургических и ренгенохирургических методов.

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The authors declare that there are no conflicts of interest present.