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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">sechenov-598</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>UROLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>УРОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>BONE METABOLISM AND EFFICACY OF THE ZOLEDRONIC ACID IN LOCALLY ADVANCED AND DISSEMINATED PROSTATE CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>КОСТНЫЙ ОБМЕН И ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ЗОЛЕДРОНОВОЙ КИСЛОТЫ ПРИ МЕСТНОРАСПРОСТРАНЕННОМ И ДИССЕМИНИРОВАННОМ РАКЕ ПРОСТАТЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глыбочко</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Glybochko</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>П.В. Глыбочко, д.м.н., член-корр. РАМН, профессор, ректор</p></bio><bio xml:lang="en"><p>P.V. Glybochko, MD, corresp. member of RAMS, prof., rector of the First MSMU named after I.M. Sechenov</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аляев</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Alyaev</surname><given-names>Y. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ю.Г. Аляев, д.м.н., профессор, член-корр. РАМН, заслуженный деятель науки РФ, директор НИИ уронефрологии и репродуктивного здоровья человека, заведующий кафедрой урологии Первого МГМУ им. И.М. Сеченова</p></bio><bio xml:lang="en"><p>Yu.G. Alyaev, MD, corresp. member of RAMS, prof., honored scientist of RF, director of the Research centre of uronephrology and reproductive health, head of the chair of urology of the First MSMU named after I.M. Sechenov</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Винаров</surname><given-names>А. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinarov</surname><given-names>A. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>А.З. Винаров, д.м.н., заместитель директора по научной работе НИИ уронефрологии и репродуктивного здоровья человека, профессор кафедры урологии Первого МГМУ им. И.М. Сеченова8 (499) 248-72-66</p><p>119435, г. Москва, ул. Большая Пироговская, д. 2, стр. 1 (Клиника урологии, 1 этаж)</p></bio><bio xml:lang="en"><p>A.Z. Vinarov, MD, deputy director for scientifi c work of the Research centre of uronephrology and reproductive health, prof. of the chair of urology of the First MSMU named after I.M. Sechenov</p></bio><email xlink:type="simple">avinarov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демидко</surname><given-names>Ю. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Demidko</surname><given-names>Y. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ю.Л. Демидко, д.м.н., заведующий кабинетом уродинамической диагностики университетской клинической больницы № 2</p></bio><bio xml:lang="en"><p>Yu.L. Demidko, MD, head of the cabinet of urodynamic diagnosis (University Hospital № 2)</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зеленова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zelenova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>О.В. Зеленова, к.м.н., доцент, заведующая учебной частью кафедры организации лекарственного обеспечения и фармакоэкономики</p></bio><bio xml:lang="en"><p>O.V. Zelenova, PhD, lecturer, head of the depot of the chair of organization of drug supply and pharmacoeconomics</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First MSMU named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2012</year></pub-date><volume>0</volume><issue>1</issue><fpage>5</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Glybochko P.V., Alyaev Y.G., Vinarov A.Z., Demidko Y.L., Zelenova O.V., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Глыбочко П.В., Аляев Ю.Г., Винаров А.З., Демидко Ю.Л., Зеленова О.В.</copyright-holder><copyright-holder xml:lang="en">Glybochko P.V., Alyaev Y.G., Vinarov A.Z., Demidko Y.L., Zelenova O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/598">https://www.sechenovmedj.com/jour/article/view/598</self-uri><abstract><p>This article deals with the problem of bone metabolism in the case of locally advanced prostate cancer.</p></abstract><trans-abstract xml:lang="ru"><p>Данная статья посвящена изучению костного обмена при местнораспространенном раке простаты.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Костный обмен</kwd><kwd>рак простаты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Bone metabolism</kwd><kwd>prostate cancer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bruder J.M., Ma J.Z., Basler J.W., Welch M.D. Prevalence of osteopenia and osteoporosis by central and peripheral bone mineral density in men with prostate cancer during androgen-deprivation therapy // Urology. — 2006. — Vol. 67(1). — P. 152–155.</mixed-citation><mixed-citation xml:lang="en">Bruder J.M., Ma J.Z., Basler J.W., Welch M.D. Prevalence of osteopenia and osteoporosis by central and peripheral bone mineral density in men with prostate cancer during androgen-deprivation therapy // Urology. — 2006. — Vol. 67(1). — P. 152–155.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Preston D.M., Torréns J.I., Harding P., Howard R.S., Duncan W.E., McLeod D.G. 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