sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-602Research ArticleUROLOGYУРОЛОГИЯTHE POSSIBILITIES OF TISSUE ENGINEERING IN THE TREATMENT OF URETHROSTENOSISВОЗМОЖНОСТИ ТКАНЕВОЙ ИНЖЕНЕРИИ В ЛЕЧЕНИИ СТРИКТУР МОЧЕИСПУСКАТЕЛЬНОГО КАНАЛААляевЮ. Г.AlyaevY. G.

Ю.Г. Аляев, д.м.н., профессор, член-корр. РАМН, заслуженный деятель науки РФ, директор НИИ уронефрологии и репродуктивного здоровья человека, заведующий кафедрой урологии Первого МГМУ им. И.М. Сеченова

Yu.G. Alyaev, MD, corresp. member of RAMS, prof., honored scientist of Russia, director of the Research centre of uronephrology and reproductive health, head of the chair of urology

ВинаровА. З.VinarovA. Z.

Андрей Зиновьевич Винаров, д.м.н., заместитель директора по научной работе НИИ уронефрологии и репродуктивного здоровья человека, профессор кафедры урологии Первого МГМУ им. И.М. Сеченова8 (499) 248-72-66

119435, г. Москва, ул. Большая Пироговская, д. 2, стр. 1 (Клиника урологии, 1 этаж)

A.Z. Vinarov, MD, deputy director for scientific work of the Research centre of uronephrology and reproductive health,  prof. of the chair of urology of the First MSMU named after I.M. Sechenov

avinarov@mail.ruГригорьевН. А.GrigorievN. A.

Н.А. Григорьев, д.м.н., профессор кафедры урологии

N.A. Grigoriev, MD, prof. of the chair of urology

БезруковЕ. А.BezrukovE. A.

Е.А. Безруков, д.м.н., доцент кафедры урологии

E.A. Bezrukov, MD, lecturer of the chair of urology

ДанилевскийМ. И.DanilevskyM. I.

М.И. Данилевский, к.б.н., кафедра урологии

M.I. Danilevsky, PhD, the chair of urology

БутнаруД. В.ButnaruD. V.

Д.В. Бутнару, к.м.н, врач-уролог кафедры урологии

D.V. Butnaru, PhD, urologist of the chair of urology

МашинГ. А.MashinG. A.

Г.А. Машин, кафедра урологии

G.A. Mashin, the chair of urology

Первый МГМУ им. И.М. СеченоваРоссияFirst MSMU named after I.M. SechenovRussian Federation201230032012011620Copyright © Alyaev Y.G., Vinarov A.Z., Grigoriev N.A., Bezrukov E.A., Danilevsky M.I., Butnaru D.V., Mashin G.A., 20122012Аляев Ю.Г., Винаров А.З., Григорьев Н.А., Безруков Е.А., Данилевский М.И., Бутнару Д.В., Машин Г.А.Alyaev Y.G., Vinarov A.Z., Grigoriev N.A., Bezrukov E.A., Danilevsky M.I., Butnaru D.V., Mashin G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/602

The article deals with various aspects of the implementation methods of tissue engineering into clinical practice of treatment of urethral strictures.

В статье рассматриваются различные аспекты внедрения методов тканевой инженерии в клиническую практику лечения стриктур мочеиспускательного канала.

Тканевая инженериястриктуры мочеиспускательного каналаTissue engineeringurethrostenosisReferencesSantucci R.A., Joyce G.F., Wise M. Male urethral stricture disease // J. Urol. — 2007. — Vol. 177. — P. 1667–1674.Santucci R.A., Joyce G.F., Wise M. Male urethral stricture disease // J. Urol. — 2007. — Vol. 177. — P. 1667–1674.Pansadoro V., Emiliozzi P. Iatrogenic prostatic urethral strictures: classification and endoscopic treatment // Urology — 1999. — Vol. 53. — P. 784–789.Pansadoro V., Emiliozzi P. Iatrogenic prostatic urethral strictures: classification and endoscopic treatment // Urology — 1999. — Vol. 53. — P. 784–789.Steven B., Brandes M.D. FACS. — Washington, 2008.Steven B., Brandes M.D. FACS. — Washington, 2008.Stormont T.J., Suman V.J., Oesterling J.E. Newly diagnosed bulbar urethral strictures: etiology and outcome of various treatments // J. Urol. — 1993. — Vol. 150. — P. 1725–1728.Stormont T.J., Suman V.J., Oesterling J.E. Newly diagnosed bulbar urethral strictures: etiology and outcome of various treatments // J. Urol. — 1993. — Vol. 150. — P. 1725–1728.Gurdal M., Tekin A., Yucebas E., Kirecci S., Sengor F. Contact neodymium: YAG laser ablation of recurrent urethral strictures using a side-firing fiber // J. Endourol. — 2003. — Vol. 17. — P. 791–794.Gurdal M., Tekin A., Yucebas E., Kirecci S., Sengor F. Contact neodymium: YAG laser ablation of recurrent urethral strictures using a side-firing fiber // J. Endourol. — 2003. — Vol. 17. — P. 791–794.Andrich D.E., Mundy A.R. Substitution urethroplasty with buccal mucosal-free grafts // J. Urol. — 2001. — Vol. 165. — P. 1131–1133.Andrich D.E., Mundy A.R. Substitution urethroplasty with buccal mucosal-free grafts // J. Urol. — 2001. — Vol. 165. — P. 1131–1133.Bhargava S., Chapple C.R. Buccal mucosal urethroplasty: Is it the new gold standard? // BJU Int. — 2004. — Vol. 93. — P. 1191–1193.Bhargava S., Chapple C.R. Buccal mucosal urethroplasty: Is it the new gold standard? // BJU Int. — 2004. — Vol. 93. — P. 1191–1193.Kane C.J., Tarman G.J., Summerton D.J., Buchmann C.E., Ward J.F., O’Reilly K.J. et al. Multi-institutional experience with buccal mucosa onlay urethroplasty for bulbar urethral reconstruction // J. Urol. — 2002. — Vol. 167. — P. 1314–1317.Kane C.J., Tarman G.J., Summerton D.J., Buchmann C.E., Ward J.F., O’Reilly K.J. et al. Multi-institutional experience with buccal mucosa onlay urethroplasty for bulbar urethral reconstruction // J. Urol. — 2002. — Vol. 167. — P. 1314–1317.Tolstunov L., Pogrel M.A., McAninch J.W. Intraoral morbidity following free buccal mucosal graft harvesting for urethroplasty // Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. — 1997. — Vol. 84. — P. 480–482.Tolstunov L., Pogrel M.A., McAninch J.W. Intraoral morbidity following free buccal mucosal graft harvesting for urethroplasty // Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. — 1997. — Vol. 84. — P. 480–482.Eppley B.L., Keating M., Rink R. A buccal mucosal harvesting technique for urethral reconstruction // J. Urol. — 1997. — Vol. 157. — P. 1268–1270.Eppley B.L., Keating M., Rink R. A buccal mucosal harvesting technique for urethral reconstruction // J. Urol. — 1997. — Vol. 157. — P. 1268–1270.Zimmerman W., Richard A. Santucci. Buccal mucosa urethroplasty for adult urethral strictures // Britt. — 2011.Zimmerman W., Richard A. Santucci. Buccal mucosa urethroplasty for adult urethral strictures // Britt. — 2011.Raya-Rivera A., Esquiliano D.R., Yoo J.J., Lopez-Bayghen E., Soker S., Atala A. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. — 2011.Raya-Rivera A., Esquiliano D.R., Yoo J.J., Lopez-Bayghen E., Soker S., Atala A. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. — 2011.El-Kassaby A.W., Retik A.B., Yoo J.J., Atala A. Urethral stricture repair with an off-the-shelf collagen matrix // J. Urol. — 2003. — Vol. 169(1). — P. 170–173.El-Kassaby A.W., Retik A.B., Yoo J.J., Atala A. Urethral stricture repair with an off-the-shelf collagen matrix // J. Urol. — 2003. — Vol. 169(1). — P. 170–173.Lin J., Hao J.R., Jin J., Deng S.M., Hu J., Na Y.Q. Homologous dermal acellular matrix graft for urethral reconstruction in man (report of 16 cases) // Zhonghua Yi Xue Za Zhi — 2005. — Vol. 85(15). — P. 1057–1059.Lin J., Hao J.R., Jin J., Deng S.M., Hu J., Na Y.Q. Homologous dermal acellular matrix graft for urethral reconstruction in man (report of 16 cases) // Zhonghua Yi Xue Za Zhi — 2005. — Vol. 85(15). — P. 1057–1059.Wang Y.Q., Li Y.Q., Liu L.Q., Xu J.J., Huo R., Li Q., Li S.K. Rabbit urethral defect repair with freeze-dried acellular bladder submucosa // BJU Int. — 2005. Vol. 21(1). — P. 62–65.Wang Y.Q., Li Y.Q., Liu L.Q., Xu J.J., Huo R., Li Q., Li S.K. Rabbit urethral defect repair with freeze-dried acellular bladder submucosa // BJU Int. — 2005. Vol. 21(1). — P. 62–65.Fu Q., Deng C.L., Liu W., Cao Y.L. Urethral replacement using epidermal cell-seeded tubular acellular bladder collagen matrix // BJU Int. Zhonghua Yi Xue Za Zhi — 2007. — Vol. 99(5). — P. 1162–1165.Fu Q., Deng C.L., Liu W., Cao Y.L. Urethral replacement using epidermal cell-seeded tubular acellular bladder collagen matrix // BJU Int. Zhonghua Yi Xue Za Zhi — 2007. — Vol. 99(5). — P. 1162–1165.Lu M.J., Wang Z., Zhou G.D., Yu B., Liu W., Cao Y.L. Construction of urethra mucosa structure in vitro by tissue engineering. — Shanghai, 2008.Lu M.J., Wang Z., Zhou G.D., Yu B., Liu W., Cao Y.L. Construction of urethra mucosa structure in vitro by tissue engineering. — Shanghai, 2008.Li C., Xu Y., Song L., Cui L., Yin S. A preliminary experimental study on urethral reconstruction using tissue engineered oral mucosa. — Shanghai, 2008.Li C., Xu Y., Song L., Cui L., Yin S. A preliminary experimental study on urethral reconstruction using tissue engineered oral mucosa. — Shanghai, 2008.Patterson J.M., Inman R.D., MacNeil S., Chapple C.R. Tissue-engineered buccal mucosa urethroplasty-clinical outcomes // Urodynamics and Female Urology — 2008.Patterson J.M., Inman R.D., MacNeil S., Chapple C.R. Tissue-engineered buccal mucosa urethroplasty-clinical outcomes // Urodynamics and Female Urology — 2008.El-Kassaby A., Shwareb T., Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. — WinstonSalem, 2008.El-Kassaby A., Shwareb T., Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. — WinstonSalem, 2008.Fu W.J., Wang Z.X., Li G., Zhang B.H., Zhang L., Hu K., Hong B.F., Wang X.X., Cui F.Z., Zhang X. A surfacemodified biodegradable urethral scaff old seeded with urethral epithelial cells. — Beij ing, 2011.Fu W.J., Wang Z.X., Li G., Zhang B.H., Zhang L., Hu K., Hong B.F., Wang X.X., Cui F.Z., Zhang X. A surfacemodified biodegradable urethral scaff old seeded with urethral epithelial cells. — Beij ing, 2011.

The authors declare that there are no conflicts of interest present.