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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">sechenov-603</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL MEDICINE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group></article-categories><title-group><article-title>The clinical signiﬁcance of adiponectimics in formation of aﬀected target-organs during the metabolic syndrome associated with nonalcoholic fatty liver disease</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническое значение адипонектинемии в формировании поражения органовмишеней при метаболическом синдроме, ассоциированном с неалкогольной жировой болезнью печени</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сагинова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Saginova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент кафедры терапии и профболезней</p></bio><bio xml:lang="en"><p>PhD, assistant of the chair of therapy and occupational diseases</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Северова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Severova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры терапии и профболезней</p></bio><bio xml:lang="en"><p>post-graduate student of the chair of therapy and occupational diseases</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галлямов</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gallyamov</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры внутренних болезней</p></bio><bio xml:lang="en"><p>post-graduate student of the chair of internal medicine</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермаков</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ermakov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., зав. лабораторией по разработке диагностических тест-систем</p></bio><bio xml:lang="en"><p>PhD, head of developing the diagnostic test systems laboratory</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rodina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., старший научный сотрудник ГУЗ «Московский научно-исследовательский институт медицинской экологии»; ассистент кафедры биохимии Первого МГМУ им. И. М. Сеченова</p></bio><bio xml:lang="en"><p>PhD, senior research fellow of the Moscow research institute of medical ecology; assistant of the chair of biochemistry of the First MSMU named after I. M. Sechenov</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктор Викторович Фомин, профессор кафедры терапии и профболезней, декан факультета довузовского образования</p><p>119435, г. Москва, ул. Россолимо, д. 11 стр. 5 (клиника профболезней) Телефон: 8 (495) 242-03-00</p></bio><bio xml:lang="en"><p>MD, prof. of the chair of therapy and occupational diseases, dean of the faculty of pre-university education</p></bio><email xlink:type="simple">fomin@mmascience.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухин</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhin</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., академик РАМН, профессор, зав. кафедрой терапии и профболезней, директор клиники нефрологии, внутренних и профессиональных болезней им. Е. М. Тареева Университетской клинической больницы № 3</p></bio><bio xml:lang="en"><p>MD, corresp. member of RAMS, prof., head of the chair of therapy and occupational diseases, director of the clinic of nephrology, medical and occupational diseases named after E. M. Tareev of the university hospital № 3</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый МГМУ им. И. М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First MSMU named after I. M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МГУ им. М. В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow state university named after M. V. Lomonosov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГУЗ «Московский научноисследовательский институт медицинской экологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow research institute of medical ecology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГУЗ «Московский научно-исследовательский институт медицинской экологии»; Первый МГМУ им. И. М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow research institute of medical ecology; First MSMU named &#13;
after I. M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2011</year></pub-date><volume>0</volume><issue>1-2</issue><fpage>18</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Saginova E.A., Severova M.M., Gallyamov M.G., Ermakov N.V., Rodina A.V., Fomin V.V., Mukhin N.A., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Сагинова Е.А., Северова М.М., Галлямов М.Г., Ермаков Н.В., Родина А.В., Фомин В.В., Мухин Н.А.</copyright-holder><copyright-holder xml:lang="en">Saginova E.A., Severova M.M., Gallyamov M.G., Ermakov N.V., Rodina A.V., Fomin V.V., Mukhin N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/603">https://www.sechenovmedj.com/jour/article/view/603</self-uri><abstract><p>The goal of this research is to estimate the clinical signiﬁcance of adiponectimics in formation of aﬀected target-organs during the metabolic syndrome associated with nonalcoholic fatty liver disease.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования – оценка клинического значения адипонектинемии в формировании поражения органов-мишеней при метаболическом синдроме, ассоциированном с неалкогольной жировой болезнью печени.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>адипонектин</kwd><kwd>адипокины</kwd><kwd>инсулинорезистентность</kwd><kwd>неалкогольная жировая болезнь печени</kwd><kwd>метаболический синдром</kwd><kwd>поражение органов-мишеней</kwd><kwd>абдоминальное ожирение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adiponectin</kwd><kwd>metabolic syndrome</kwd><kwd>nonalcoholic fatty liver disease</kwd><kwd>insulinoresistance</kwd><kwd>target organ damage</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках Гранта Президента РФ для государственной поддержки молодых российских ученых – кандидатов наук (конкурс – МК-2010), договор № 02.120.11.8327-МК от 28.06.2010. по теме «Факторы развития и прогрессирования нефропатий у больных ожирением».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ritchie S.A., Connell J.M. 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