sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-604Research ArticleCLINICAL IMMUNOLOGYКЛИНИЧЕСКАЯ ИММУНОЛОГИЯThe specific features of cytokine profile of patients with bronchial asthma in an acute stageОсобенности цитокинового профиля у больных бронхиальной астмой в стадии обостренияАнисимоваН. Ю,AnisimovaN. Yu.

к.б.н., старший научный сотрудник лаборатории клеточного иммунитета

PhD, senior research fellow of the laboratory of cellular immunity

ДолжиковаЮ. М.DolzhikovaYu. M.

аспирант лаборатории клеточного иммунитета

post-graduate student of the laboratory of cellular immunity

КокушковД. В.KokushkovD. V.

к.м.н., доцент кафедры клинической иммунологии и аллергологии

PhD, lecturer of the chair of clinical immunology and allergology

БорисоваТ. В.BorisovaT. V.

аспирант кафедры клинической иммунологии и аллергологии

post-graduate student of the chair of clinical immunology and allergology

ЧикилеваИ. О.ChikilevaI. O.

к.б.н., старший научный сотрудник лаборатории клеточного иммунитета

PhD, senior research fellow of the laboratory of cellular immunity

СокуренкоС. И.SokurenkoS. I.

д.м.н., профессор кафедры клинической иммунологии и аллергологии

MD, prof. of the chair of clinical immunology and allergology

КиселевскийМ. В.KiselevskyM. V.

д.м.н., профессор, сотрудник

MD, prof.

КарауловА. В.KaraulovA. V.

Александр Викторович Караулов, д.м.н., член-корр. РАМН, профессор, заведующий кафедрой клинической иммунологии и аллергологии

119435, г. Москва, ул. Б. Пироговская д. 2, к. 6 Телефон: 8 (495) 118-50-47

MD, corresp. member of RAMS, prof., head of the chair of clinical immunology and allergology

Российский онкологический научный центр им. Н. Н. Блохина РАМНРоссияRussian cancer research centre named after N. N. Blokhin of RAMSRussian FederationПервый МГМУ им. И. М. СеченоваРоссияFirst MSMU named after I. M. SechenovRussian FederationРоссийский онкологический научнвй центр им. Н. Н. Блохина РАМНРоссияRussian cancer research centre named after N. N. Blokhin of RAMSRussian FederationМГМУ им. И. М. СеченоваРоссияFirst MSMU named after I. M. SechenovRussian Federation20113003201101-22629Copyright © Anisimova N.Y., Dolzhikova Y.M., Kokushkov D.V., Borisova T.V., Chikileva I.O., Sokurenko S.I., Kiselevsky M.V., Karaulov A.V., 20112011Анисимова Н.Ю., Должикова Ю.М., Кокушков Д.В., Борисова Т.В., Чикилева И.О., Сокуренко С.И., Киселевский М.В., Караулов А.В.Anisimova N.Y., Dolzhikova Y.M., Kokushkov D.V., Borisova T.V., Chikileva I.O., Sokurenko S.I., Kiselevsky M.V., Karaulov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/604

The aim of this research is to investigate the features of staphylococcal microflora of sportsmen of different specializations.

Цель работы – изучение особенностей стафилококковой микрофлоры у спортсменов различных специализаций.

бронхиальная астмацитокинысывороточная концентрацияспонтанная и индуцированная продукцияbronchial asthmathe serum concentrationspontaneous and induced productionReferencesBusse W.W., Lemanske R.F., Asthma. N. Engl. J Med. 2001; 44: 350–362; Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002;3:715–720.Busse W.W., Lemanske R.F., Asthma. N. Engl. J Med. 2001; 44: 350–362; Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. Asthma: an epidemic of dysregulated immunity. Nat Immunol. 2002;3:715–720.Herrick C.A., Bottomly K. To respond or not to respond: T cells in allergic asthma. Nat. Rev. Immunol. 2003;3:405– 412.Herrick C.A., Bottomly K. To respond or not to respond: T cells in allergic asthma. Nat. Rev. Immunol. 2003;3:405– 412.Georas S.N., Guo J., De Fanis U., Casolaro V. T-helper cell type-2 regulation in allergic disease. Eur. Respir. J. 2005;26 (6):1119–1137.Georas S.N., Guo J., De Fanis U., Casolaro V. T-helper cell type-2 regulation in allergic disease. Eur. Respir. J. 2005;26 (6):1119–1137.McKinley L., Alcorn J.F., Peterson A., Dupont R.B., Kapadia S., Logar A., Henry A., Irvin C.G., Piganelli J.D., Ray A., Kolls J.K. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 2008;181:4089–4097.McKinley L., Alcorn J.F., Peterson A., Dupont R.B., Kapadia S., Logar A., Henry A., Irvin C.G., Piganelli J.D., Ray A., Kolls J.K. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 2008;181:4089–4097.Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Pagé N., Olivenstein R, Elias J., Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 2001;108: 430–438.Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Pagé N., Olivenstein R, Elias J., Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 2001;108: 430–438.Jatakanon A., Uasuf C., Maziak W., Lim S., Chung K.F., Barnes P.J. Neutrophilic inflammation in severe persistent asthma. Am. J. Respir. Crit. Care Med. 1999;160:1532– 1539.Jatakanon A., Uasuf C., Maziak W., Lim S., Chung K.F., Barnes P.J. Neutrophilic inflammation in severe persistent asthma. Am. J. Respir. Crit. Care Med. 1999;160:1532– 1539.Louis R., Lau L.C,. Bron A.O., Roldaan A.C., Radermecker M., Djukanović R. The relationship between airways inflammation and asthma severity. Am J. Respir. Crit. Care Med. 2000; 161:9–16.Louis R., Lau L.C,. Bron A.O., Roldaan A.C., Radermecker M., Djukanović R. The relationship between airways inflammation and asthma severity. Am J. Respir. Crit. Care Med. 2000; 161:9–16.Iwakura Y., Nakae S., Saijo S., Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol. Rev. 2008;266:55–79.Iwakura Y., Nakae S., Saijo S., Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol. Rev. 2008;266:55–79.Nakajima H. and Hirose K. Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma. Netw. 2010 February; 10(1): 1–4.Nakajima H. and Hirose K. Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma. Netw. 2010 February; 10(1): 1–4.King C., Brennan S., Thompson P.J., Stewart G.A. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J. Immunol. 1998;161(7):3645–3651.King C., Brennan S., Thompson P.J., Stewart G.A. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J. Immunol. 1998;161(7):3645–3651.Kicic A., Sutanto E.N., Stevens P.T., Knight D.A., Stick S.M. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am. J. Resp. and Critical Care Med. 2006;174(10):1110–1118.Kicic A., Sutanto E.N., Stevens P.T., Knight D.A., Stick S.M. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am. J. Resp. and Critical Care Med. 2006;174(10):1110–1118.Kamimura D., Ishihara K., Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol Biochem.and Pharmacol. 2003;149:1–38Kamimura D., Ishihara K., Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol Biochem.and Pharmacol. 2003;149:1–38Dienz O., Rincon M. The effects of IL-6 on CD4 T cell responses. Clin. Immunol. 2009;130(1):27–33.Dienz O., Rincon M. The effects of IL-6 on CD4 T cell responses. Clin. Immunol. 2009;130(1):27–33.Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 2003;299(5609):1033–1036.Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 2003;299(5609):1033–1036.Mangan P.R., Harrington L.E., O’Quinn D.B., Helms W.S., Bullard D.C., et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441(7090):231–234.Mangan P.R., Harrington L.E., O’Quinn D.B., Helms W.S., Bullard D.C., et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441(7090):231–234.Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179–189.Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179–189.Wendy A., Neveu1, Jenna L., Allard,2 Danielle M Raymond, 2 Lorraine M Bourassa,2 Stephanie M Burns,2 Janice Y Bunn,3 Charles G Irvin,2 David A Kaminsky,2 and Mercedes Rincon Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function Respir Res. 2010; 11(1): 11–28.Wendy A., Neveu1, Jenna L., Allard,2 Danielle M Raymond, 2 Lorraine M Bourassa,2 Stephanie M Burns,2 Janice Y Bunn,3 Charles G Irvin,2 David A Kaminsky,2 and Mercedes Rincon Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function Respir Res. 2010; 11(1): 11–28.

The authors declare that there are no conflicts of interest present.