<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">sechenov-612</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>KIDNEY AND HEART INVOLVEMENT IN ARTERIAL HYPERTENSION: EVOLUTION OF VIEW FROM R. BRIGHT AND E.M. TAREEV TO PRESENT DAYS</article-title><trans-title-group xml:lang="ru"><trans-title>ЭВОЛЮЦИЯ ПРЕДСТАВЛЕНИЙ О ПОРАЖЕНИИ СЕРДЦА И ПОЧЕК ПРИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ ОТ Р. БРАЙТА И Е.М. ТАРЕЕВА ДО НАШИХ ДНЕЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подзолков</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Podzolkov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, начальник управления послевузовского и дополнительного профессионального образования, заведующий кафедрой факультетской терапии № 2 лечебного факультета</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Булатов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulatov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>км.н., докторант кафедры факультетской терапии № 2 лечебного факультета</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова Минздравсоцразвития России»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2010</year></pub-date><volume>0</volume><issue>2</issue><fpage>14</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Podzolkov V.I., Bulatov V.A., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Подзолков В.И., Булатов В.А.</copyright-holder><copyright-holder xml:lang="en">Podzolkov V.I., Bulatov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/612">https://www.sechenovmedj.com/jour/article/view/612</self-uri><abstract><p>Evolution of concepts of pathogenesis and treatment of heart and kidney involvement as integrated continuum are described</p></abstract><trans-abstract xml:lang="ru"><p>Представлена эволюция представлений о патогенезе и подходах к лечению поражения сердца и почек при артериальной гипертонии в рамках единого континуума</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>органы-мишени</kwd><kwd>сердце</kwd><kwd>почка</kwd><kwd>кардиоренальный континуум</kwd><kwd>гипертрофия левого желудочка</kwd><kwd>микроальбуминурия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertonia</kwd><kwd>target organ</kwd><kwd>heart</kwd><kwd>kidney</kwd><kwd>cardio-renal continuum</kwd><kwd>left ventricular hypertrophy</kwd><kwd>microalbuminuria</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шляхто Е.В., Конради А.О. Роль генетических факторов в ремоделировании сердечно-сосудистой системы при гипертонической болезни / / Артериал. гипертензия. — 2002. — № 8. — С. 107—114.</mixed-citation><mixed-citation xml:lang="en">Шляхто Е.В., Конради А.О. Роль генетических факторов в ремоделировании сердечно-сосудистой системы при гипертонической болезни / / Артериал. гипертензия. — 2002. — № 8. — С. 107—114.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Adler С.Р. Polyploidization and augmentation of heart muscle cells during normal cardiac growth and in cardiac hypertrophy / / The Development and Regenerative Potential of Cardiac Muscle / Eds J.O. Oberpriller, J.C. Oberpriller, A. Mauro. — Edition Chur: Harwood Academic Publishers, 1991. — P. 227—252.</mixed-citation><mixed-citation xml:lang="en">Adler С.Р. Polyploidization and augmentation of heart muscle cells during normal cardiac growth and in cardiac hypertrophy / / The Development and Regenerative Potential of Cardiac Muscle / Eds J.O. Oberpriller, J.C. Oberpriller, A. Mauro. — Edition Chur: Harwood Academic Publishers, 1991. — P. 227—252.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Agabiti-Rosei E., Muiesan M.L. Hypertensive left ventricular hypertrophy: pathophysiological and clinical issues // Blood Press. - 2001. - Vol. 10. - P. 288-298.</mixed-citation><mixed-citation xml:lang="en">Agabiti-Rosei E., Muiesan M.L. Hypertensive left ventricular hypertrophy: pathophysiological and clinical issues // Blood Press. - 2001. - Vol. 10. - P. 288-298.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Banerjee P., Clark A.L., Nikitin N., Cleland J.G. Diastolic heart failure. Paroxysmal or chronic? // Eur. J. Heart Fail. — 2004.-Vol. 6 .-P.427-431.</mixed-citation><mixed-citation xml:lang="en">Banerjee P., Clark A.L., Nikitin N., Cleland J.G. Diastolic heart failure. Paroxysmal or chronic? // Eur. J. Heart Fail. — 2004.-Vol. 6 .-P.427-431.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bianchi S., Bigazzi R-, Campese V.M. Microalbuminuria in essential hypertension: significance, pathophysiology, and therapeutic implications //Am. J. Kidney Dis. — 1999. — Vol. 34. - P. 973-995.</mixed-citation><mixed-citation xml:lang="en">Bianchi S., Bigazzi R-, Campese V.M. Microalbuminuria in essential hypertension: significance, pathophysiology, and therapeutic implications //Am. J. Kidney Dis. — 1999. — Vol. 34. - P. 973-995.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bigazzi R-, Bianchi S., Baldari D. et al. Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension / / J. Hypertens. - 1998. - Vol. 16. - P. 1325-1333.</mixed-citation><mixed-citation xml:lang="en">Bigazzi R-, Bianchi S., Baldari D. et al. Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension / / J. Hypertens. - 1998. - Vol. 16. - P. 1325-1333.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Brown M.J., Palmer C.R., Castaigne A. et al. Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT) // Lancet. — 2000. - Vol. 356. - P. 366-372.</mixed-citation><mixed-citation xml:lang="en">Brown M.J., Palmer C.R., Castaigne A. et al. Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT) // Lancet. — 2000. - Vol. 356. - P. 366-372.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bulatov V.A., Stenehjem A., Os I. Left ventricular mass assessed by electrocardiography and albumin excretion rate as a continuum in untreated essential hypertension // J. Hypertens. - 2001. - Vol. 19. - P. 1473-1478.</mixed-citation><mixed-citation xml:lang="en">Bulatov V.A., Stenehjem A., Os I. Left ventricular mass assessed by electrocardiography and albumin excretion rate as a continuum in untreated essential hypertension // J. Hypertens. - 2001. - Vol. 19. - P. 1473-1478.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Caetano E.R., Zatz R-, Saldanha L.B., Praxedes J.N. Hypertensive nephrosclerosis as a relevant cause of chronic renal failure / / Hypertension. — 2001. — Vol. 38. — P. 171-176.</mixed-citation><mixed-citation xml:lang="en">Caetano E.R., Zatz R-, Saldanha L.B., Praxedes J.N. Hypertensive nephrosclerosis as a relevant cause of chronic renal failure / / Hypertension. — 2001. — Vol. 38. — P. 171-176.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Campese V.M., Bianchi S., Bigazzi R- Is microalbuminuria a predictor of cardiovascular and renal disease in patients with essential hypertension? // Curr. Opin. Nephrol. Hypertens. — 2000. — Vol. 9. — P. 143—147.</mixed-citation><mixed-citation xml:lang="en">Campese V.M., Bianchi S., Bigazzi R- Is microalbuminuria a predictor of cardiovascular and renal disease in patients with essential hypertension? // Curr. Opin. Nephrol. Hypertens. — 2000. — Vol. 9. — P. 143—147.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Col! E., Campos B., Gonzalez-Nunez D. et ai Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency // J. Nephrol. — 2003. — Vol. 16. — P. 357-364.</mixed-citation><mixed-citation xml:lang="en">Col! E., Campos B., Gonzalez-Nunez D. et ai Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency // J. Nephrol. — 2003. — Vol. 16. — P. 357-364.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">DiBona G.F. Neural control of renal function: role of renal alpha adrenoceptors//J. Cardiovasc. Pharmacol. - 1985. — Vol. 7, suppl. 8. — P. S18—23.</mixed-citation><mixed-citation xml:lang="en">DiBona G.F. Neural control of renal function: role of renal alpha adrenoceptors//J. Cardiovasc. Pharmacol. - 1985. — Vol. 7, suppl. 8. — P. S18—23.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dzau V.J., Antman E.M., Black H.R. et ai The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease) / / Circulation. — 2006. — Vol. 114. — P. 2850-2870.</mixed-citation><mixed-citation xml:lang="en">Dzau V.J., Antman E.M., Black H.R. et ai The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease) / / Circulation. — 2006. — Vol. 114. — P. 2850-2870.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dzau V.J., Antman E.M., Black H.R. etal. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions// Circulation. - 2006. - Vol. 114,- P.2871-2891.</mixed-citation><mixed-citation xml:lang="en">Dzau V.J., Antman E.M., Black H.R. etal. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions// Circulation. - 2006. - Vol. 114,- P.2871-2891.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hesse I.F., Johns E.J. The subtype of alpha-adrenoceptor involved in the neural control of renal tubular sodium reabsorption in the rabbit / / J. Physiol. — 1984. — Vol. 352. — P. 527-538.</mixed-citation><mixed-citation xml:lang="en">Hesse I.F., Johns E.J. The subtype of alpha-adrenoceptor involved in the neural control of renal tubular sodium reabsorption in the rabbit / / J. Physiol. — 1984. — Vol. 352. — P. 527-538.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hillege H.L., Girbes A.R., de Kam P.J. et al. Renal function, neurohormonal activation, and survival in patients with chronic heart failure / / Circulation. — 2000. — Vol. 102. — P. 203-210.</mixed-citation><mixed-citation xml:lang="en">Hillege H.L., Girbes A.R., de Kam P.J. et al. Renal function, neurohormonal activation, and survival in patients with chronic heart failure / / Circulation. — 2000. — Vol. 102. — P. 203-210.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B. Prevalence and natural history of electrocardiographic left ventricular hypertrophy // Am. J. Med. — 1983.-Vol. 75.-P .4 -1 1 .</mixed-citation><mixed-citation xml:lang="en">Kannel W.B. Prevalence and natural history of electrocardiographic left ventricular hypertrophy // Am. J. Med. — 1983.-Vol. 75.-P .4 -1 1 .</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., Stampfer M.J., Castelli W.P., Verier J. The prognostic significance of proteinuria: the Framingham study //Am. Heart J. - 1984.-Vol. 108. - P. 1347-1352.</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., Stampfer M.J., Castelli W.P., Verier J. The prognostic significance of proteinuria: the Framingham study //Am. Heart J. - 1984.-Vol. 108. - P. 1347-1352.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Leehey D.J., Singh A.K., Alavi N., Singh R. Role of angiotensin II in diabetic nephropathy // Kidney Int. Suppl. — 2000. - Vol. 77. - P. S93-98.</mixed-citation><mixed-citation xml:lang="en">Leehey D.J., Singh A.K., Alavi N., Singh R. Role of angiotensin II in diabetic nephropathy // Kidney Int. Suppl. — 2000. - Vol. 77. - P. S93-98.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Locatelli F, Marcelli D., Conte F. et al. Cardiovascular disease in chronic renal failure: the challenge continues. Registro Lombardo Dialisi e Trapianto / / Nephrol. Dial. Transplant. — 2000. — Vol. 15, suppl. 5. — P. 69—80.</mixed-citation><mixed-citation xml:lang="en">Locatelli F, Marcelli D., Conte F. et al. Cardiovascular disease in chronic renal failure: the challenge continues. Registro Lombardo Dialisi e Trapianto / / Nephrol. Dial. Transplant. — 2000. — Vol. 15, suppl. 5. — P. 69—80.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Luke R.G. Hypertensive nephrosclerosis: pathogenesis and prevalence. Essential hypertension is an important cause of end-stage renal disease // Nephrol. Dial. Transplant. — 1999. - Vol. 14. - P. 2271-2278.</mixed-citation><mixed-citation xml:lang="en">Luke R.G. Hypertensive nephrosclerosis: pathogenesis and prevalence. Essential hypertension is an important cause of end-stage renal disease // Nephrol. Dial. Transplant. — 1999. - Vol. 14. - P. 2271-2278.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Magri P., Rao M.A., Cangianiello S. et at. Early impairment of renal hemodynamic reserve in patients with asymptomatic heart failure is restored by angiotensin 11 antagonism // Circulation. - 1998. - Vol. 98. - P. 2849-2854.</mixed-citation><mixed-citation xml:lang="en">Magri P., Rao M.A., Cangianiello S. et at. Early impairment of renal hemodynamic reserve in patients with asymptomatic heart failure is restored by angiotensin 11 antagonism // Circulation. - 1998. - Vol. 98. - P. 2849-2854.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">MayetJ., Foale R.A. Changes in left ventricular function in cardiac hypertrophy// Left Ventricular Hypertrophy / Ed. D.J. Sheridan. — London: Churchill, 1998. — P. 93—99.</mixed-citation><mixed-citation xml:lang="en">MayetJ., Foale R.A. Changes in left ventricular function in cardiac hypertrophy// Left Ventricular Hypertrophy / Ed. D.J. Sheridan. — London: Churchill, 1998. — P. 93—99.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">McMurray J.J.V., Stewart S. The burden of heart failure // Eur. Heart J. Suppl. - 2003. - Vol. 5. - P. 13-113.</mixed-citation><mixed-citation xml:lang="en">McMurray J.J.V., Stewart S. The burden of heart failure // Eur. Heart J. Suppl. - 2003. - Vol. 5. - P. 13-113.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Meyrier A., Simon P. Nephroangiosclerosis and hypertension: things are not as simple as you might think/ / Nephrol. Dial. Transplant. — 1996. — Vol. 11. — P. 2116—2120.</mixed-citation><mixed-citation xml:lang="en">Meyrier A., Simon P. Nephroangiosclerosis and hypertension: things are not as simple as you might think/ / Nephrol. Dial. Transplant. — 1996. — Vol. 11. — P. 2116—2120.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Osborn J.L., Holdaas H., Thames M.D., DiBona G.F. Renal adrenoceptor mediation of antinatriuretic and renin secretion responses to low frequency renal nerve stimulation in the dog// Circ. Res. - 1983. - Vol. 53. - P. 298-305.</mixed-citation><mixed-citation xml:lang="en">Osborn J.L., Holdaas H., Thames M.D., DiBona G.F. Renal adrenoceptor mediation of antinatriuretic and renin secretion responses to low frequency renal nerve stimulation in the dog// Circ. Res. - 1983. - Vol. 53. - P. 298-305.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Paul M., Ganten D. The molecular basis of cardiovascular hypertrophy: the role of the renin-angiotensin system // J. Cardiovasc. Pharmacol. — 1992. - Vol. 19, suppl. 5. — P. S5I-58.</mixed-citation><mixed-citation xml:lang="en">Paul M., Ganten D. The molecular basis of cardiovascular hypertrophy: the role of the renin-angiotensin system // J. Cardiovasc. Pharmacol. — 1992. - Vol. 19, suppl. 5. — P. S5I-58.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pedrinelli R. Microalbuminuria in essential hypertension. A marker of systemic vascular damage? // Nephrol. Dial. Transplant. - 1997. - Vol. 12. - P. 379-381.</mixed-citation><mixed-citation xml:lang="en">Pedrinelli R. Microalbuminuria in essential hypertension. A marker of systemic vascular damage? // Nephrol. Dial. Transplant. - 1997. - Vol. 12. - P. 379-381.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips R.A., Diamond J.A. Left ventricular hypertrophy, congestive heart failure, and coronary flow reserve abnormalities in hypertension // Hypertension: a Companion to Brenner and Rector’s The Kidney / Eds S. Oparil, M.A. Weber. — Philadelphia: W.B. Saunders, 2000. - P. 244-277.</mixed-citation><mixed-citation xml:lang="en">Phillips R.A., Diamond J.A. Left ventricular hypertrophy, congestive heart failure, and coronary flow reserve abnormalities in hypertension // Hypertension: a Companion to Brenner and Rector’s The Kidney / Eds S. Oparil, M.A. Weber. — Philadelphia: W.B. Saunders, 2000. - P. 244-277.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips R.A., Goldman M.E., Ardeljan M. etal. Determinants of abnormal left ventricular filling in early hypertension // J. Am. Coll. Cardiol. - 1989. - Vol. 14. - P. 979-985.</mixed-citation><mixed-citation xml:lang="en">Phillips R.A., Goldman M.E., Ardeljan M. etal. Determinants of abnormal left ventricular filling in early hypertension // J. Am. Coll. Cardiol. - 1989. - Vol. 14. - P. 979-985.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ritz E., Orth S., Weinreich T., Wagner J. Systemic hypertension versus intraglomerular hypertension in progression // Kidney Int. — 1994. — Vol. 45. — P. 438—442.</mixed-citation><mixed-citation xml:lang="en">Ritz E., Orth S., Weinreich T., Wagner J. Systemic hypertension versus intraglomerular hypertension in progression // Kidney Int. — 1994. — Vol. 45. — P. 438—442.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rizzoni D.} Castellano M., Porteri E. etal. Effects of low and high doses of fosinopril on the structure and function of resistance arteries // Hypertension. — 1995. — Vol. 26. — P. 118—123.</mixed-citation><mixed-citation xml:lang="en">Rizzoni D.} Castellano M., Porteri E. etal. Effects of low and high doses of fosinopril on the structure and function of resistance arteries // Hypertension. — 1995. — Vol. 26. — P. 118—123.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ruggenenti P., Perna A., Mosconi L. et al. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. «Gruppo ItalianodiStudi EpidemiologiciinNefrologia»(GISEN)// Kidney lnt. - 1998. - Vol. 53. - P. 1209-1216.</mixed-citation><mixed-citation xml:lang="en">Ruggenenti P., Perna A., Mosconi L. et al. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. «Gruppo ItalianodiStudi EpidemiologiciinNefrologia»(GISEN)// Kidney lnt. - 1998. - Vol. 53. - P. 1209-1216.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope L.M. Kidney dysfunction: a sensitive predictor of cardiovascular risk // Am. J. Hypertens. — 2001. — Vol. 14. — P. 213S-217S.</mixed-citation><mixed-citation xml:lang="en">Ruilope L.M. Kidney dysfunction: a sensitive predictor of cardiovascular risk // Am. J. Hypertens. — 2001. — Vol. 14. — P. 213S-217S.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope L.M. The kidney as a sensor of cardiovascular risk in essential hypertension / / J. Am. Soc. Nephrol. — 2002. — Vol. 13, suppl. 3. - P. SI65-168.</mixed-citation><mixed-citation xml:lang="en">Ruilope L.M. The kidney as a sensor of cardiovascular risk in essential hypertension / / J. Am. Soc. Nephrol. — 2002. — Vol. 13, suppl. 3. - P. SI65-168.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope L.M., Campo C., Rodriguez-Artalejo F. et al. Blood pressure and renal function: therapeutic implications / / J. Hypertens. - 1996. - Vol. 14. - P. 1259-1263.</mixed-citation><mixed-citation xml:lang="en">Ruilope L.M., Campo C., Rodriguez-Artalejo F. et al. Blood pressure and renal function: therapeutic implications / / J. Hypertens. - 1996. - Vol. 14. - P. 1259-1263.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma A.M. Renal involvement in hypertensive cardiovascular disease // Eur. Heart J. — 2003. — Vol. 5. — P. F12—F18.</mixed-citation><mixed-citation xml:lang="en">Sharma A.M. Renal involvement in hypertensive cardiovascular disease // Eur. Heart J. — 2003. — Vol. 5. — P. F12—F18.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sheridan D.J., Kingsbury M.P. Mechanisms od reduced coronary reserve in cardiac hypertrophy// Left Ventricular Hypertrophy. 1st ed. / Ed. D.J. Sheridan. — London: Churchill, 1998. - P. 135-143.</mixed-citation><mixed-citation xml:lang="en">Sheridan D.J., Kingsbury M.P. Mechanisms od reduced coronary reserve in cardiac hypertrophy// Left Ventricular Hypertrophy. 1st ed. / Ed. D.J. Sheridan. — London: Churchill, 1998. - P. 135-143.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Silberberg J.S., Barre P.E., Prichard S.S., Sniderman A.D. Impact of left ventricular hypertrophy on survival in end-stage renal disease // Kidney Int. — 1989. — Vol. 36. — P. 286—290.</mixed-citation><mixed-citation xml:lang="en">Silberberg J.S., Barre P.E., Prichard S.S., Sniderman A.D. Impact of left ventricular hypertrophy on survival in end-stage renal disease // Kidney Int. — 1989. — Vol. 36. — P. 286—290.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Staessen J.A., Wang J.G., Ginocchio G. et al. The deletion/ insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk//J. Hypertens. — 1997.-Vol. 1 5 ,- P. 1579-1671.</mixed-citation><mixed-citation xml:lang="en">Staessen J.A., Wang J.G., Ginocchio G. et al. The deletion/ insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk//J. Hypertens. — 1997.-Vol. 1 5 ,- P. 1579-1671.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">The GISEN Gropu. Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) // Lancet. — 1997. — Vol. 349. - P. 1857-1863.</mixed-citation><mixed-citation xml:lang="en">The GISEN Gropu. Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) // Lancet. — 1997. — Vol. 349. - P. 1857-1863.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tracy R. Ishii T. What is «nephrosclerosis»? Lessons from the US, Japan, and Mexico/ / Nephrol. Dial. Transplant. — 2000. - Vol. 15. - P. 1357-1366.</mixed-citation><mixed-citation xml:lang="en">Tracy R. Ishii T. What is «nephrosclerosis»? Lessons from the US, Japan, and Mexico/ / Nephrol. Dial. Transplant. — 2000. - Vol. 15. - P. 1357-1366.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">USRDS: U.S. Renal Data System. USRDS 2002 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. National Institutes of Health, National Institute ofDiabetesand Digestive and Kidney Diseases. — Bethesda, 2002.</mixed-citation><mixed-citation xml:lang="en">USRDS: U.S. Renal Data System. USRDS 2002 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. National Institutes of Health, National Institute ofDiabetesand Digestive and Kidney Diseases. — Bethesda, 2002.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Viberti G.C., Hill R.D., Jarrett R.J. et al. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus // Lancet. — 1982. — Vol. 1. — P. 1430-1432.</mixed-citation><mixed-citation xml:lang="en">Viberti G.C., Hill R.D., Jarrett R.J. et al. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus // Lancet. — 1982. — Vol. 1. — P. 1430-1432.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Volpe M., Magri P., Rao M.A. etal. Intrarenal determinants of sodium retention in mild heart failure: effects of angiotensin- converting enzyme inhibition / / Hypertension. — 1997. - Vol. 30. - P. 168-176.</mixed-citation><mixed-citation xml:lang="en">Volpe M., Magri P., Rao M.A. etal. Intrarenal determinants of sodium retention in mild heart failure: effects of angiotensin- converting enzyme inhibition / / Hypertension. — 1997. - Vol. 30. - P. 168-176.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Weber K.T., Sun Y, DhallaA.K. Extracellular matrix and fibrosis in cardiac hypertrophy // Left Ventricular Hypertrophy. 1st ed. / Ed. D.J. Sheridan. — London: Churchill, 1998. — P. 37—44.</mixed-citation><mixed-citation xml:lang="en">Weber K.T., Sun Y, DhallaA.K. Extracellular matrix and fibrosis in cardiac hypertrophy // Left Ventricular Hypertrophy. 1st ed. / Ed. D.J. Sheridan. — London: Churchill, 1998. — P. 37—44.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Weisstuch J.M., Dworkin L.D. Does essential hypertension cause end-stage renal disease? / / Kidney Int. Suppl. — 1992. - Vol. 36. - P. S33-37.</mixed-citation><mixed-citation xml:lang="en">Weisstuch J.M., Dworkin L.D. Does essential hypertension cause end-stage renal disease? / / Kidney Int. Suppl. — 1992. - Vol. 36. - P. S33-37.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yamazaki T., Komuro I., Yazaki Y. Triggers for cardiac hypertrophy// Left Ventricular Hypertrophy. 1st ed. / Ed. D.J. Sheridan. — London: Churchill, 1998. — P. 71—76.</mixed-citation><mixed-citation xml:lang="en">Yamazaki T., Komuro I., Yazaki Y. Triggers for cardiac hypertrophy// Left Ventricular Hypertrophy. 1st ed. / Ed. D.J. Sheridan. — London: Churchill, 1998. — P. 71—76.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zanchetti A., Hansson L., Dahlof B. et al. Effects of individual risk factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study. HOT Study Group / / J. Hypertens. — 2001. — Vol. 19. — P. 1149—1159.</mixed-citation><mixed-citation xml:lang="en">Zanchetti A., Hansson L., Dahlof B. et al. Effects of individual risk factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study. HOT Study Group / / J. Hypertens. — 2001. — Vol. 19. — P. 1149—1159.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
