sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-614Research ArticleCARDIOLOGYКАРДИОЛОГИЯThe stress induced hyperglycemia of pathophysiologycal significance in stroke patientsПатофизиологическая значимость стрессовой гипергликемии у пациентов с ишемическим инсультомЛитвицкийП. Ф.LitvitskyP. F.

д.м.н., профессор, заведующий кафедрой патофизиологии

MD, prof., head of the chair of pathophysiology

НуралиеваН. Ф.NuralievaN. F.

студентка 5 курса лечебного факультета

the 5-th year student of the therapeutical faculty

СергееваС. П.SergeevaS. P.

Светлана Павловна Сергеева, к.м.н., доцент кафедры патофизиологии

119992, г. Москва, ул. Трубецкая, д. 8, стр. 2

8 (917) 552–33–48

Svetlana Pavlovna Sergeeva, PhD, associate prof. of the chair of pathophysiology

8–2 Trubetskaya str., Moscow, 119992

8 (917) 552–33–48

svetlanapalna@mail.ruПервый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First MSMURussian Federation201430032014014754Copyright © Litvitsky P.F., Nuralieva N.F., Sergeeva S.P., 20142014Литвицкий П.Ф., Нуралиева Н.Ф., Сергеева С.П.Litvitsky P.F., Nuralieva N.F., Sergeeva S.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/614

Stress induced hyperglycemia is a transient increase glucose blood level during the acute phase of ischemic stroke. Hyperglycemia enhances initiated by cerebral ischemia neuronal death, blood-brain barrier destruction, leads to hemorrhagic transformation, promotes the formation of brain edema. This increases the size of ischemic penumbra and increases the severity of neurological deficit. Stress hyperglycemia as a consequence of stress-realizing system activation is a significant pathogenetic link in ischemic stroke patients.

Гипергликемия при стрессе представляет собой транзиторное повышение уровня глюкозы плазмы крови в остром периоде ишемического инсульта. Гипергликемия потенцирует инициированное церебральной ишемией повреждение нейронов, гематоэнцефалического барьера, способствует геморрагической трансформации ИшИ и развитию отека мозга. За счет этого увеличиваются размеры ишемической полутени (пенумбры) и нарастает выраженность неврологического дефицита. В целом, гипергликемия при стрессе, как результат активации стресс-реализующей системы является значимым звеном патогенеза у пациентов с ишемическим инсультом.

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The authors declare that there are no conflicts of interest present.