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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">sechenov-616</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>The rational approach to selection of anticoagulation for stroke prevention in patients with atrial fibrillation of non-valvular etiology</article-title><trans-title-group xml:lang="ru"><trans-title>Рациональный подход к выбору антикоагулянтной терапии для профилактики инсультов у пациентов с фибрилляцией предсердий неклапанной этиологии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Напалков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Napalkov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Александрович Напалков, д.м.н., заместитель директора по научной и инновационной деятельности; заведующий научно-исследовательским отделом аритмологии НИЦ, профессор кафедры факультетской терапии № 1</p><p>119435, г. Москва, ул. Б. Пироговская, д. 6</p><p>8 (499) 248–62–22</p></bio><bio xml:lang="en"><p>Dmitry Aleksandrovich Napalkov,, MD, deputy director in research and innovation; head of the Research Department of arrhythmology of the Research Centre, professor of the chair of the faculty therapy № 1</p><p>6 B. Pirigovskaya str., Moscow, 119435</p><p>8 (499) 248–62–22</p></bio><email xlink:type="simple">noo@mmascience.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-терапевт Клинического центра</p></bio><bio xml:lang="en"><p>physician of the Clinical Centre</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НОКЦ «Аритмология»; Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Centre «Arrhythmology»; I.M. Sechenov First MSMU</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First MSMU</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2014</year></pub-date><volume>0</volume><issue>1</issue><fpage>55</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Napalkov D.A., Sokolova A.A., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Напалков Д.А., Соколова А.А.</copyright-holder><copyright-holder xml:lang="en">Napalkov D.A., Sokolova A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/616">https://www.sechenovmedj.com/jour/article/view/616</self-uri><abstract><p>The question of how to use most eff ectively and safely drugs from the group of oral anticoagulants for prevention of thromboembolic complications (TEC) in patients with atrial fi brillation (AF) non-valvular etiology is analyzed in this paper.</p></abstract><trans-abstract xml:lang="ru"><p>В данной работе анализируется вопрос о том, как максимально эффективно и безопасно использовать препараты из группы пероральных антикоагулянтов для профилактики тромбоэмболических осложнений (ТЭО) у пациентов с фибрилляцией предсердий (ФП) неклапанной этиологии.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиология</kwd><kwd>профилактика инсультов</kwd><kwd>антикоагулянтная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiology</kwd><kwd>stroke prevention</kwd><kwd>anticoagulant therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines for the management of atrial fi brillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery / A.J. 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