sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-672Research ArticleUROLOGYУРОЛОГИЯVitamins, carotenoids and microelements in prostate carcinogenesisВитамины, каротиноиды и микроэлементы в динамике онкогенеза предстательной железыГлыбочкоП. В.GlybochkoP. V.

д.м.н., профессор, чл.-корр. РАН, ректор

MD, corresp. member of Russian Academy of Sciences (RAS), prof., rector

ЗезеровЕ. Г.ZezerovE. G.

Евгений Гаврилович Зезеров, профессор кафедры биохимии

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

Телефон: 8 (495) 622–96–73

Evgeny Gavrilovich Zezerov, prof. of the chair of biochemistry

8–2 Trubetskaya str., Moscow, 119991

Tel.: 8 (495) 622–96–73

vladzez@yandex.ruБутнаруД. В.ButnaruD. V.

к.м.н, врач-уролог клиники урологии

PhD, physician

СпиричевВ. Б.SpirichevV. B.

д.б.н., профессор, заслуженный деятель науки РФ, старший научный сотрудник

Doctor of biological sciences, prof., honored scientist of Russia, senior research fellow

БекетоваН. А.BeketovaN. A.

к.х.н., старший научный сотрудник

PhD, senior research fellow

БарашковГ. К.BarashkovG. K.

профессор, сотрудник Лаборатории диагностики тяжелых металлов

prof. of the Laboratory of Heavy Metal Diagnostics

ВаршавскийВ. А.VarshavskyV. A.

д.м.н., профессор кафедры патологической анатомии

АляевЮ. Г.AlyaevYu. G.

д.м.н., профессор, чл.-корр. РАН, заслуженный деятель науки РФ, заведующий кафедрой урологии

MD, corresp. member of RAS, prof., honored scientist of RF, head of the chair of urology

СеверинС. Е.SeverinS. E.

д.х.н., профессор, чл.-корр. РАН., заведующий кафедрой биохимии

Doctor of Chemistry, corresp. member of RAS, prof., head of the chair of biochemistry

ОсиповЕ. В.OsipovE. V.

к.б.н., доцент кафедры биохимии

PhD, associate prof. of the chair of biochemistry

ПереверзеваО. Г.PereverzevaO. G.

научный сотрудник

research fellow

БезруковЕ. А.BezrukovE. A.

д.м.н., профессор кафедры урологии

MD, prof. of the chair of urology

ВинаровА. З.VinarovA. Z.

д.м.н., профессор кафедры урологии

M.D., prof. of the chair of urology

Первый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical University (MSMU)Russian FederationПервый МГМУ им. И.М. СеченоваРоссияUrology Clinic of the I.M. Sechenov First MSMURussian FederationНаучно-исследовательский институт питания РАНРоссияFederal State Budgetary Institution «Institute of Nutrition» (FSBIN)Russian FederationПервый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First MSMURussian Federation20153003201501419Copyright © Glybochko P.V., Zezerov E.G., Butnaru D.V., Spirichev V.B., Beketova N.A., Barashkov G.K., Varshavsky V.A., Alyaev Y.G., Severin S.E., Osipov E.V., Pereverzeva O.G., Bezrukov E.A., Vinarov A.Z., 20152015Глыбочко П.В., Зезеров Е.Г., Бутнару Д.В., Спиричев В.Б., Бекетова Н.А., Барашков Г.К., Варшавский В.А., Аляев Ю.Г., Северин С.Е., Осипов Е.В., Переверзева О.Г., Безруков Е.А., Винаров А.З.Glybochko P.V., Zezerov E.G., Butnaru D.V., Spirichev V.B., Beketova N.A., Barashkov G.K., Varshavsky V.A., Alyaev Y.G., Severin S.E., Osipov E.V., Pereverzeva O.G., Bezrukov E.A., Vinarov A.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/672

Epidemiology and prophylaxis of prostate cancer (CaP) has remained a pressing and challenging issue for many decades. One of its aspects is the role of food additives and diet which diff er for people of various regions. Multiple dubious epidemiologic and clinical studies on this issue warrant further clinical and experimental research into the role of vitamins and microelements in different stages of prostate cancer initiation and development. The use of complex clinical and histological evaluation of urologic patients and blood sampling is viewed for vitamins as well as lipid peroxidation products and 21 microelements. The test subjects included 115 male patients of the Urology clinic – 95 patients with different kinds of prostate gland oncopathology and 20 males without prostate pathology. The results have shown a statistically significant deviation of the levels of certain substances in the blood. Patients with CaP had reduced levels of antioxidants (lycopene, vitamin Е, germanium, selenium) and increased levels of pro-oxidants (aluminum and conjugated dienes). We have demonstrated that patients with high-grade prostatic intraepithelial neoplasia (HGPIN) have decreased blood levels of vitamin C, total carotenoids, germanium, selenium and increased levels of aluminum and conjugated dienes. Malignant transformation of prostate gland cells is associated with a decreased blood level of antioxidants (lycopene, carotenoids, vitamin Е, vitamin C, germanium, sulfur, selenium) and a increased level of pro-oxidants (aluminum and conjugated dienes). The aforementioned changes associated with the mechanism of prostate carcinogenesis are already detected in patients with HGPIN (precancer) with no further progression in patients with developed CaP.

Проблема эпидемиологии и профилактики рака предстательной железы (РПЖ) в течение многих десятилетий остаётся актуальной и нерешённой. Один из аспектов этой проблемы – роль различных пищевых добавок и диеты, различающихся для людей разных регионов. На фоне многочисленных и неоднозначных эпидемиологических и клинических исследований по данной проблеме необходимы дальнейшие клинико-экспериментальные работы, посвящённые изучению роли витаминов, витаминоподобных, биологически активных веществ и микроэлементов на разных этапах инициации и формирования рака простаты. Использован комплекс клинических, гистологических методов обследования урологического больного и методы анализа в крови витаминов и родственных им соединений, а также продуктов перекисного окисления липидов и 21 микроэлемента. Объекты исследования – 115 мужчин-пациентов клиники урологии Первого Московского государственного медицинского университета им. И.М. Сеченова, из них 95 пациентов с различной онкопатологией простаты и 20 мужчин без выявленных заболеваний этой железы. Доказаны статистически достоверные следующие изменения концентрации исследованных веществ в крови. У больных с РПЖ уменьшено содержание антиоксидантов – ликопина, витамина Е, германия, селена и увеличено содержание прооксидантов – алюминия и диеновых конъюгатов. Для пациентов с простатической интраэпителиальной неоплазией высокой степени (ПИН ВС) доказано уменьшение в крови содержания витамина С, суммарных каротиноидов, германия и селена и увеличение – алюминия и диеновых конъюгатов. При раковом перерождении клеток простаты уровень в крови антиоксидантов (ликопина, каротиноидов, витаминов Е и С, германия, серы, селена) понижен, а для прооксидантов (алюминия и диеновых конъюгатов) повышен. Показанные изменения, связанные с механизмом канцерогенеза железы, зафиксированы уже стадии предрака (ПИН ВС) без дальнейшего их усиления на стадии сформированного рака простаты.

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Rol antioksidantov i produktov perekisnogo okislenya lipidov pri zabolevanyah predstatelnoy zhelezy (The role of antioxidants and lipid peroxidation products in prostate pathology). Vrach (Doktor) 2006; (6):24-26. Lecture. Russian.Butnaru D, Bezrukov E, Spirichev V, Zezerov E, Barashkov G, Beketova N, Pereverzeva O. Rol antioksidantov i produktov perekisnogo okislenya lipidov pri zabolevanyah predstatelnoy zhelezy (The role of antioxidants and lipid peroxidation products in prostate pathology). Vrach (Doktor) 2006; (6):24-26. Lecture. Russian.Zezerov EG, Kovalenko NA, Zabezhinskaya OM, Lesnichuk SA, Kurynin RV, Aslamazov EG, Vinarov AZ, Bezrukov EA, Polyakovskiy KA, Butnaru DV, Spirichev VB, Beketova NA, Pereverzeva OG, Popova ON, Barashkov GK, Zaitseva LI, Glukhov AI, Belushkina NN, Alyaev YuG. 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Biomedicine of the XXI century: achievements and prospects for development. Collection of scientifi c papers. Moscow: Edition of Russian Academy of Natural Sciences) 2008. p.149-156. Russian.Zezerov EG. Rak predstatelnoy zhelezi (molekularnobiologicheskiye aspekti i diagnostika). (Prostate cancer – molecular and biological aspects and diagnostic). V: Redaktor Rahmanin YA. Biomeditsina XXI veka: dostizhenya i perspektivniye napravlenya razvitiya. Sbornik nauchnih trudov RAEN. Moskva. ( In: Rakhmanin YuA editor. Biomedicine of the XXI century: achievements and prospects for development. Collection of scientifi c papers. Moscow: Edition of Russian Academy of Natural Sciences) 2008. p.149-156. Russian.Zezerov EG, Polyakovsky KA, Zabezhinskaya OM, Butnaru DV, Glukhov AI. 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The authors declare that there are no conflicts of interest present.