sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-681Research ArticleCLINICAL RESEARCHКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯEpithelial reticular cells of the thymus and the regulatory T-lymphocytesРетикулярные эпителиоциты тимуса и регуляторные Т-лимфоцитыТорбекВ. Э.TorbekV. E.

Виктория Эдуардовна Торбек, профессор кафедры гистологии, цитологии и эмбриологии

117513, г. Москва, ул. Акад. Бакулева, д. 6

Телефон: 8 (495) 629–75–69

Viktoriya Eduardovna Torbek, prof. of the chair of histology, cytology and embryology

6 Akad. Bakulev str., Moscow, 117513

Tel.: 8 (495) 629–75–69

aakasianenko@mail.ruКузнецовС. Л.KuznetsovS. L.

д.м.н., профессор, заведующий кафедрой гистологии, цитологии и эмбриологии

MD, prof., head of the chair of histology, cytology and embryology

Первый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First MSMURussian Federation201530032015014549Copyright © Torbek V.E., Kuznetsov S.L., 20152015Торбек В.Э., Кузнецов С.Л.Torbek V.E., Kuznetsov S.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/681

The article presents a review of the literature. The article presents the published data on the role of reticular epithelial cells in the formation of specific microenvironment in the cortex and medulla of thymic lobules. Thymic microenvironment plays a key role in T-cell differentiation. Discusses the role of medullar epithelial cells in the development of regulatory T-lymphocytes and induction of tolerance.

Статья имеет обзорный характер. Приводятся литературные данные, касающиеся важной роли ретикулярных эпителиоцитов в формировании специфического микроокружения в корковом и мозговом веществе долек тимуса. Микроокружение играет ключевую роль в процессах Т-клеточной дифференцировки. Обсуждается роль медуллярных эпителиоцитов в формировании толерантности и развитии регуляторных Т-лимфоцитов.

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The authors declare that there are no conflicts of interest present.