sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-684Research ArticlePHARMACOLOGYФАРМАКОЛОГИЯThe methods of assessment of quality and safety of medicaments on the basis of low molecular weight heparinsМетоды оценки качества и безопасности лекарственных средств на основе низкомолекулярных гепариновАриановаЕ. А.ArianovaE. A.

аспирант кафедры фармацевтической химии с курсом токсикологической химии

post-graduate student of the chair of pharmaceutical chemistry with a course of toxicological chemistry

БогачукМ. Н.BogachukM. N.

аспирант кафедры фармацевтической химии с курсом токсикологической химии

post-graduate student of the chair of pharmaceutical chemistry with a course of toxicological chemistry

ПередеряевО. И.PerederyaevO. I.

Олег Игоревич Передеряев, к.фарм.н., доцент кафедры фармацевтической химии с курсом токсикологической химии

119019, г. Москва, Никитский бульвар, д. 13. Телефон: 8 (495) 691-13-92

PhD, lecturer of the chair of pharmaceutical chemistry with a course of toxicological chemistry

pharma@bk.ruПервый МГМУ им. И. М. СеченоваРоссияFirst MSMU named after I. M. SechenovRussian Federation20113009201103-42023Copyright © Arianova E.A., Bogachuk M.N., Perederyaev O.I., 20112011Арианова Е.А., Богачук М.Н., Передеряев О.И.Arianova E.A., Bogachuk M.N., Perederyaev O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/684

To consider the methods for assessing quality and safety of drugs on the basis of low molecular weight heparin.

Рассмотреть наиболее актуальные методы качественного и количественного определения низкомолекулярного гепарина, а также анализ его некоторых примесей.

гепариннизкомолекулярный гепаринпрепараты низкомолекулярного гепаринавысокоэффективная жидкостная хроматографииякапиллярный электрофорезкапиллярный зональный электрофорезheparinlow molecular weight heparinlow molecular weight heparin drugshigh-performance liquid chromatographycapillary electrophoresiscapillary zone electrophoresisReferencesСелеменев В.Ф., Хохлова О.Н., Хохлов В.Ю., Щербинин Р.Л. Определение гепарина спектрофотометрическим и фотоколориметрическим методами // Химико-фармацевтический журнал. 1999. № 8. С.47–48.Селеменев В.Ф., Хохлова О.Н., Хохлов В.Ю., Щербинин Р.Л. Определение гепарина спектрофотометрическим и фотоколориметрическим методами // Химико-фармацевтический журнал. 1999. № 8. С.47–48.Rahul P. Patel, Christian Narkowicz, Glenn A. Jacobson. Effective reversed-phase ion pair high-performance liquid chromatography method for the separation and characterization of intact low-molecular-weight heparins // Analytical Biochemistry. 2009. V.387. P. 113–121.Rahul P. 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PYE // Combined strong anion-exchange HPLC and PAGE approach for the purification of heparan sulphate oligosaccharides // Biochem. J. 2001. V.354. P.141–147.Stacie L. Eldridge, Albert K. Korir, Sarah M. Gutierrez et al. Heterogeneity of depolymerized heparin SEC fractions: to pool or not to pool? // Carbohydrate Research. 2008. V. 343. P. 2963–2970.Stacie L. Eldridge, Albert K. Korir, Sarah M. Gutierrez et al. Heterogeneity of depolymerized heparin SEC fractions: to pool or not to pool? // Carbohydrate Research. 2008. V. 343. P. 2963–2970.Andr´e Ziegler, Joseph Zaia. Size-exclusion chromatography of heparin oligosaccharides at high and low pressure. // Journal of Chromatography B. 2006. V. 837. P. 76–86.Andr´e Ziegler, Joseph Zaia. Size-exclusion chromatography of heparin oligosaccharides at high and low pressure. // Journal of Chromatography B. 2006. V. 837. P. 76–86.Timothy King J., Umesh R. Desai. 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The authors declare that there are no conflicts of interest present.