sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-713Research ArticleCLINICAL RESEARCHКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯPerspectives of using circulating tumor dna as a marker of malignant neoplasms’ statusПерспективы использования циркулирующей опухолевой ДНК в качестве маркера состояния злокачественных новообразованийЧебышевН. В.ChebyshevN. B.

Николай Васильевич Чебышев, д.м.н., академик РАО, заслуженный профессор, заведующий кафедрой биологии и общей генетики

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

тел.: 8 (495) 609–14–00

Nikolay Vasilyevich Chebyshev, MD, academician of Russian Academy of Education, honored prof., head of the chair of biology and general genetics

8–2 Trubetskaya, Moscow, 119991

tel.: 8 (495) 609–14–00

rektorat@mma.ruДегтяревскаяТ. Ю.DegtyarevskayaT. Yu.

к.б.н., доцент кафедры биологии и общей генетики

PhD, associate prof. of the chair of biology and general genetics

СушенцевН. А.SushentsevN. A.

студент 3-го курса лечебного факультета

3-d year student of the medical faculty

АракелянА. С.ArakelyanA. S.

студент 2-го курса лечебного факультета

2-nd year student of the medical faculty

ГалееваА. К.GaleevaA. K.

студент 2-го курса лечебного факультета

2-nd year student of the medical faculty

Первый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First MSMURussian Federation201530092015031822Copyright © Chebyshev N.B., Degtyarevskaya T.Y., Sushentsev N.A., Arakelyan A.S., Galeeva A.K., 20152015Чебышев Н.В., Дегтяревская Т.Ю., Сушенцев Н.А., Аракелян А.С., Галеева А.К.Chebyshev N.B., Degtyarevskaya T.Y., Sushentsev N.A., Arakelyan A.S., Galeeva A.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/713

In this article the review of genetic analysis of circulating tumor DNA as one of the most intensively studied diagnostic methods in oncology is present. Due to its high sensitivity and specifi city and the ability to be used in solving diff erent clinical problems such as diagnosing and then monitoring of tumor burden, evaluating the probability of disease relapse and also correction of therapy used in case of detecting tumor’s resistance to it, this method is one of the most perspective to be implemented into public healthcare. Nevertheless, its high cost, a little quantity of clinical trials and necessity of standardization cannot aff ord this method to be used in clinic now. 

В стать е представлен обзор одного из наиболее интенсивно изучаемых в настоящее время методов диагностики онкологических заболеваний – генетического анализа циркулирующей опухолевой ДНК. Благодаря высокой чувствительности и специфичности, а также возможности применения при решении различных клинических задач – диагностике, контроле течения, оценке вероятности рецидива онкологических заболеваний, а также коррекции проводимого лечения при обнаружении резистентности опухоли к химиотерапевтическим препаратам – данный метод представляется наиболее перспективным с точки зрения внедрения в общественное здравоохранение. Тем не менее, высокая стоимость исследования, малое количество проведенных клинических испытаний и необходимость стандартизации на данный момент не могут позволить ему занять место в клинике. 

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The authors declare that there are no conflicts of interest present.