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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">sechenov-719</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕДИАТРИЯ</subject></subj-group></article-categories><title-group><article-title>To the problems of safe use of nonsteroidal anti-inflammatory drugs in pediatric rheumatologist practice: opportunities in local therapy</article-title><trans-title-group xml:lang="ru"><trans-title>К вопросам безопасности применения нестероидных противовоспалительных препаратов в практике детского ревматолога: возможности локальной терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелешкина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Meleshkina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент кафедры детских болезней</p></bio><bio xml:lang="en"><p>PhD, assistant of the chair of childhood diseases</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чебышева</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chebysheva</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Николаевна Чебышева, к.м.н., доцент кафедры детских болезней</p><p>119435, г. Москва, ул. Б. Пироговская, д. 19</p><p>8 (499) 248–64–79</p></bio><bio xml:lang="en"><p>Svetlana Nikolaevna Chebysheva, PhD, associate prof. of the chair of childhood diseases</p><p>19 B. Pirogovskaya str., Moscow, 119435</p><p>8 (499) 248–64–79</p></bio><email xlink:type="simple">kaf-child@mma.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First MSMU</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2014</year></pub-date><volume>0</volume><issue>2</issue><fpage>54</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Meleshkina A.V., Chebysheva S.N., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Мелешкина А.В., Чебышева С.Н.</copyright-holder><copyright-holder xml:lang="en">Meleshkina A.V., Chebysheva S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/719">https://www.sechenovmedj.com/jour/article/view/719</self-uri><abstract><p>The article deals with local therapy in the practice of pediatric rheumatologist. Separately considered the possibility of using nonsteroidal anti-inflammatory drugs. Particular attention is paid to the effectiveness and safety of pharmacological treatment of pain and inflammatory syndromes in rheumatic diseases.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена вопросам локальной терапии в практике детского ревматолога. Отдельно рассматриваются возможности применения нестероидных противовоспалительных препаратов. Особое внимание уделяется как эффективности, так и безопасности медикаментозного лечения болевого и воспалительного синдромов при ревматических заболеваниях.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>детская ревматология</kwd><kwd>терапия</kwd><kwd>нестероидные противовоспалительные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pediatric rheumatology</kwd><kwd>therapy</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Самсыгина Г.А., Щербакова М.Ю. Ревматология и кардиология детского возраста. М. Медпрактика. 2004. 744 с.</mixed-citation><mixed-citation xml:lang="en">Samsygina G.A., Scherbakova M.Yu. Rheumatology and pediatric cardiology. M. Medpraktika. 2004. 744 p</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. 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