sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-803Research ArticleTHE ACHIEVEMENTS OF MODERN PATHOPHYSIOLOGYДОСТИЖЕНИЯ СОВРЕМЕННОЙ ПАТОФИЗИОЛОГИИOpportunities for management of macrophage phenotype reprogrammingВозможности управления процессом перепрограммирования фенотипа макрофаговСахаровВ. Н.SakharovV. N.

аспирант

post-graduate

ЛитвицкийП. Ф.LitvitskyP. F.

Пeтр Францевич Литвицкий, д.м.н., чл.-корр. РАН, профессор, заведующий кафедрой патофизиологии

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8 (985) 769–07–38

Petr Frantsevich Litvitsky, MD, corresp. member of RAS, prof., head of the chair of pathophysiology

8/2 Trubetskaya str., Moscow, 119991

8 (985) 769–07–38

litvicki@mma.ruПервый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First MSMURussian Federation201430122014048996Copyright © Sakharov V.N., Litvitsky P.F., 20142014Сахаров В.Н., Литвицкий П.Ф.Sakharov V.N., Litvitsky P.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/803

This article reviews the recent literature on opportunities for reprogramming of macrophage phenotypes. Much attention is devoted to the stimulus, signal pathways and its effects as well as some regulational mechanisms.

Представлен обзор литературы последних лет о возможностях целенаправленного перепрограммирования фенотипа активированных макрофагов. Основное внимание уделено характеристике индукторов их активации, реализации сигнальных путей и их эффектов, а также механизмов их регуляции.

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The authors declare that there are no conflicts of interest present.