sechenovSechenov Medical JournalСеченовский вестник2218-73322658-3348Сеченовский Университетsechenov-819Research ArticleNEUROLOGYНЕВРОЛОГИЯMAGNESIUM IN THE TREATMENT AND PREVENTION OF MIGRAINEМАГНИЙ В ЛЕЧЕНИИ И ПРОФИЛАКТИКЕ МИГРЕНИАкарачковаЕ. С.AkarachkovaE. S.

Е.С. Акарачкова, к.м.н., ведущий научный сотрудник Лаборатории патологии вегетативной нервной системы Научно-исследовательского центра

E.S. Akarachkova, PhD, senior researcher of the Laboratory of pathology of autonomic nervous system of the Research Centre

АртеменкоА. Р.ArtemenkoA. R.

Ада Равильевна Артеменко, д.м.н., ведущий научный сотрудник Лаборатории патологии вегетативной нервной системы Научно-исследовательского центра8 (499) 248–69–97

119435, г. Москва, ул. Россолимо, д. 11., стр. 1

A.R. Artemenko, MD, senior researcher of the Laboratory of pathology of autonomic nervous system of the Research Centre

kgv2006@yandex.ruПервый МГМУ им. И.М. СеченоваРоссияFirst MSMU named after I.M. SechenovRussian Federation201230122012043438Copyright © Akarachkova E.S., Artemenko A.R., 20122012Акарачкова Е.С., Артеменко А.Р.Akarachkova E.S., Artemenko A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sechenovmedj.com/jour/article/view/819

Magnesium — intracellular cation — is important in many pathological processes including the pathogenesis of migraine. Magnesium deficiency in patients with migraine may be developed as a result of genetic inability to absorb magnesium and its excessive loss with stress because of low nutritional intake and a number of other reasons. Migraine magnesium deficiency contributes in changing the activity of NMDA-receptors, distribution of cortical depression hyperaggregation platelets, affects the function of serotonin receptors and metabolism of many neurotransmitters. Intravenous magnesium-containing drugs show high efficacy in the treatment and prevention of migraine.

Магний — внутриклеточный катион — имеет важное значение при многих патологических процессах, в том числе и в патогенезе мигрени. Дефицит магния у пациентов с мигренью может развиться как вследствие генетической неспособности усваивать магний, так и чрезмерных его потерь при стрессах, из-за низкого алиментарного потребления и ряда других причин. При мигрени дефицит магния способствует изменению активности NMDA-рецепторов, распространению корковой депрессии, гиперагрегации тромбоцитов, влияет на функции серотониновых рецепторов и метаболизм многих нейромедиаторов. Внутривенные и пероаральные магнийсодержащие препараты показывают высокую эффективность в лечении и профилактике мигрени.

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The authors declare that there are no conflicts of interest present.