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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47093/2218-7332.2022.13.4.4-17</article-id><article-id custom-type="elpub" pub-id-type="custom">sechenov-881</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL MEDICINE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group></article-categories><title-group><article-title>Significance of zinc deficiency correction for practical medicine: a review</article-title><trans-title-group xml:lang="ru"><trans-title>Значение коррекции дефицита цинка в практической медицине: обзор</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7838-1366</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скальный</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skalny</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скальный Анатолий Викторович, д-р мед. наук, профессор, директор Центра биоэлементологии и экологии человека; заведующий кафедрой медицинской элементологии Медицинского института; научный руководитель Лаборатории биотехнологии и прикладной биоэлементологии</p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p><p>ул. Миклухо-Маклая, д. 6, г. Москва, 117198</p><p>ул. Советская, д. 14, г. Ярославль, 150003</p><p>Тел.: +7 (915) 061-70-30</p></bio><bio xml:lang="en"><p>Anatoly V. Skalny, Dr. of Sci. (Medicine), Professor, Director of the Center for Bioelementology and Human Ecology; Head of the Department of Medical Elementology; Scientific Director, Laboratory of Biotechnology and Applied Bioelementology</p><p>8/2, Trubetskaya str., Moscow, 119991</p><p>6, Miklukho-Maklaya str., Moscow, 117198</p><p>14, Sovetskaya str., Yaroslavl, 150003</p><p>Tel.: +7 (915) 061-70-30</p></bio><email xlink:type="simple">skalny3@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4118-4646</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сотникова</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sotnikova</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сотникова Татьяна Ивановна, канд. мед. наук, доцент кафедры терапии; врач</p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p><p>2-й Боткинский проезд, д. 5, г. Москва, 125284</p></bio><bio xml:lang="en"><p>Tatiana I. Sotnikova, Cand. of Sci. (Medicine), Associate Professor, Therapy Department; doctor</p><p>8/2, Trubetskaya str., Moscow, 119991</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1373-6354</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коробейникова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korobeynikova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коробейникова Татьяна Викторовна, канд. техн. наук, научный сотрудник, заведующая лабораторией молекулярной диетологии Центра биоэлементологии и экологии человека; доцент кафедры медицинской элементологии </p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p><p>ул. Миклухо-Маклая, д. 6, г. Москва, 117198</p></bio><bio xml:lang="en"><p>Tatiana V. Korobeynikova, Cand. of Sci. (Engineering), Research Associate, Head of the Laboratory of Molecular Dietology, Center for Bioelementology and Human Ecology; Associate Professor, Department of Medical Elementology</p><p>8/2, Trubetskaya str., Moscow, 119991</p><p>6, Miklukho-Maklaya str., Moscow, 117198</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0348-6192</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тиньков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tinkov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тиньков Алексей Алексеевич, канд. мед. наук, ведущий научный сотрудник Центра биоэлементологии и экологии человека; доцент кафедры медицинской элементологии Медицинского института; научный сотрудник Лаборатории экобиомониторинга и контроля качества</p><p>ул. Трубецкая, д. 8, стр. 2, г. Москва, 119991</p><p>ул. Миклухо-Маклая, д. 6, г. Москва, 117198</p><p>ул. Советская, д. 14, г. Ярославль, 150003</p></bio><bio xml:lang="en"><p>Alexey A Tinkov, Cand. of Sci. (Medicine), Leading Researcher, Center for Bioelementology and Human Ecology; Associate Professor, Department of Medical Elementology, Medical Institute; Researcher, Laboratory of Ecobiomonitoring and Quality Control</p><p>8/2, Trubetskaya str., Moscow, 119991</p><p>6, Miklukho-Maklaya str., Moscow, 117198</p><p>14, Sovetskaya str., Yaroslavl, 150003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет); ФГАОУ ВО «Российский университет дружбы народов» (РУДН); ФГБОУ ВО «Ярославский государственный университет им. П.Г. Демидова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University); Peoples’ Friendship University of Russia (RUDN University); P.G. Demidov Yaroslavl State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет); ГБУЗ «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University); City Clinical Hospital named after S.P. Botkin of the Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет); ФГАОУ ВО «Российский университет дружбы народов» (РУДН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University); Peoples’ Friendship University of Russia (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2022</year></pub-date><volume>13</volume><issue>4</issue><fpage>4</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Skalny A.V., Sotnikova T.I., Korobeynikova T.V., Tinkov A.A., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Скальный А.В., Сотникова Т.И., Коробейникова Т.В., Тиньков А.А.</copyright-holder><copyright-holder xml:lang="en">Skalny A.V., Sotnikova T.I., Korobeynikova T.V., Tinkov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/881">https://www.sechenovmedj.com/jour/article/view/881</self-uri><abstract><p>Zinc deficiency is highly prevalent ranging from 10% to 30–40% of the population in developed and developing countries respectively. Low zinc level has been found to be associated with 0.7% of overall mortality and 1.0% of disability-adjusted life years (DALYs) worldwide. In turn, available research evidence has shown that zinc supplementation in its deficiency can reduce the risk of preterm birth, promote the physical development of children, and have certain protective effect against the components of the metabolic syndrome. A positive effect of zinc supplementation on recovery from pneumonia, diarrhea, and common cold has been reported. It is expected that the most pronounced effect of zinc supplementation may be observed in individuals with subclinical or severe zinc deficiency. Due to the high incidence of zinc deficiency, as well as its significant contribution to a wide range of pathologies, the correction of low zinc level may be considered as economically effective strategy. Thus, the results of the existing studies have demonstrated the efficiency of zinc intake for prophylaxis or as an adjuvant therapy of a wide range of pathologies.</p></abstract><trans-abstract xml:lang="ru"><p>Частота дефицита цинка составляет от 10 до 30–40% населения в экономически развитых и развивающихся странах соответственно. Установлено, что дефицит цинка ассоциирован с 0,7% общей смертности и 1,0% утраченных по нетрудоспособности лет жизни (disability-adjusted life years, DALYs) по всему миру. В свою очередь, данные многочис­ленных исследований, посвященных изучению эффективности применения цинка, продемонстрировали, что коррекция обеспеченности организма цинком может снижать риск преждевременных родов, способствует физическому развитию детей, а также обладает протективным эффектом в отношении компонентов метаболического синдрома. Отмечено положительное влияние цинка на выздоровление при пневмониях, диареях и простудных заболеваниях. Ожидается, что наиболее выраженный эффект применения цинка может отмечаться у лиц с субклиническим или выраженным его дефицитом. В связи с высокой частотой дефицита цинка, а также его значительным вкладом в широкий спектр патологий коррекция этого дефицита является экономически обоснованным мероприятием. Таким образом, результаты проведенных исследований свидетельствуют об эффективности применения цинка для профилактики или в качестве средства адъювантной терапии широкого спектра заболеваний.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дефицит цинка</kwd><kwd>микронутриенты</kwd><kwd>заболеваемость</kwd><kwd>эпидемиология</kwd><kwd>коррекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>zinc deficiency</kwd><kwd>micronutrient</kwd><kwd>morbidity</kwd><kwd>epidemiology</kwd><kwd>correction</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при поддержке Минобрнауки России, государственное задание ЯрГУ FENZ-2023-0004.</funding-statement><funding-statement xml:lang="en">The study was performed with the support of the Russian Ministry of Science and Higher Education, Project № 0856-2020-0008.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">King J.C. 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