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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">sechenov</journal-id><journal-title-group><journal-title xml:lang="en">Sechenov Medical Journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Сеченовский вестник</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2218-7332</issn><issn pub-type="epub">2658-3348</issn><publisher><publisher-name>Сеченовский Университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47093/2218-7332.2023.14.2.57-66</article-id><article-id custom-type="elpub" pub-id-type="custom">sechenov-941</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONCOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНКОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>Personalized 3D printed implants in the treatment of extensive  chest wall tumors: clinical cases</article-title><trans-title-group xml:lang="ru"><trans-title>Применение индивидуализированных 3D-имплантов в лечении обширных опухолей грудной стенки: клинические случаи</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2038-3729</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валиев</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Valiev</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валиев Аслан Камраддинович, д-р мед. наук, заведующий отделом общей онкологии </p><p>Каширское шоссе, д. 24, г. Москва, 115522</p><p>+7 (926) 142-87-05</p></bio><bio xml:lang="en"><p>Aslan K. Valiev, Dr. of Sci. (Medicine), Head of the Department of General Oncology</p><p>24, Kashirskoye highway, Moskow, 115552</p><p>+7 (926) 142-87-05</p></bio><email xlink:type="simple">dsion@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4744-6141</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кононец</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kononets</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кононец Павел Вячеславович, д-р мед. наук, директорнаучно-исследовательского института клинической онкологии им. Н.Н. Трапезникова </p><p>Каширское шоссе, д. 24, г. Москва, 115522</p></bio><bio xml:lang="en"><p>Pavel V. Kononets, Dr. of Sci. (Medicine), Director ofthe Research Clinical Institute of Oncology named afterN.N. Trapeznikov</p><p>24, Kashirskoye highway, Moskow, 115552</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8135-4841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харатишвили</surname><given-names>Т. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharatishvili</surname><given-names>T. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Харатишвили Таймураз Кобаевич, д-р мед. наук, профессор, ведущий научный сотрудник отдела общей онкологии</p><p>Каширское шоссе, д. 24, г. Москва, 115522</p></bio><bio xml:lang="en"><p>Teimuraz K. Kharatishvili, Dr. of Sci. (Medicine), Professor,Leading Researcher, Department of General Oncology</p><p>24, Kashirskoye highway, Moskow, 115552</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-0400-3331</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сальков</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Salkov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сальков Александр Геннадьевич, врач-онколог отдела общей онкологии</p><p>Каширское шоссе, д. 24, г. Москва, 115522</p></bio><bio xml:lang="en"><p>Alexander G. Salkov, Oncologist, Department of Oncology</p><p>24, Kashirskoye highway, Moskow, 115552</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8814-8381</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петроченко</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrochenko</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петроченко Николай Сергеевич, канд. мед. наук, научный сотрудник отдела общей онкологии</p><p>Каширское шоссе, д. 24, г. Москва, 115522</p></bio><bio xml:lang="en"><p>Nikolay S. Petrochenko, Cand. of Sci. (Medicine), Researcher,Department of General Oncology</p><p>24, Kashirskoye highway, Moskow, 115552</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3595-3472</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шин</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Shin</surname><given-names>A.  R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шин Александр Родионович, канд. мед. наук, заведующий отделением анестезиологии-реанимации</p><p>Каширское шоссе, д. 24, г. Москва, 115522</p></bio><bio xml:lang="en"><p>Alexander R. Shin, Cand. of Sci. (Medicine), Head ofthe Department of Anesthesiology and Intensive Care</p><p>24, Kashirskoye highway, Moskow, 115552</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6426-3200</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сытов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sytov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сытов Александр Викторович, канд. мед. наук, заведующий отделением реанимации и интенсивной терапии</p><p>Каширское шоссе, д. 24, г. Москва, 115522</p></bio><bio xml:lang="en"><p>Alexander V. Sytov, Cand. of Sci. (Medicine), Head of theDepartment of Resuscitation and Intensive Care</p><p>24, Kashirskoye highway, Moskow, 115552</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3635-4380</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефименко</surname><given-names>О.</given-names></name><name name-style="western" xml:lang="en"><surname>Efimenko</surname><given-names>O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефименко Ольга, технический директор ООО «ТИОС»;начальник отдела моделирования НИИ Бионики и персонифицированной медицины</p><p>ул. Новаторов, д. 6, г. Москва, 119421</p><p>ул. Чапаевская, д. 89, г. Самара, 443099</p></bio><bio xml:lang="en"><p>Olga Efimenko, Technical Director, LLC “TIOS”; Head ofthe Modeling Department, Research Institute of Bionics andPersonalized Medicine</p><p>6, Novators str., Moscow, 119421</p><p>89, Chapaevskaya str., Samara, 443099</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin National Medical Research Center of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «ТИОС»; ФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>LLC “TIOS”; Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>07</month><year>2023</year></pub-date><volume>14</volume><issue>2</issue><issue-title>Special issue «Oncology»</issue-title><fpage>57</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Valiev A.K., Kononets P.V., Kharatishvili T.K., Salkov A.G., Petrochenko N.S., Shin A.R., Sytov A.V., Efimenko O., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Валиев А.К., Кононец П.В., Харатишвили Т.К., Сальков А.Г., Петроченко Н.С., Шин А.Р., Сытов А.В., Ефименко О.</copyright-holder><copyright-holder xml:lang="en">Valiev A.K., Kononets P.V., Kharatishvili T.K., Salkov A.G., Petrochenko N.S., Shin A.R., Sytov A.V., Efimenko O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sechenovmedj.com/jour/article/view/941">https://www.sechenovmedj.com/jour/article/view/941</self-uri><abstract><p>3D printing has opened new opportunities for the development of personalized systems for prosthetics of extensive chest wall defects after radical surgical interventions for malignant tumors. However, risk factors for an adverse outcome of such operations have not yet been identified.</p><sec><title>Clinical cases</title><p>Clinical cases. A 65-year-old man with primary chondrosarcoma of the V rib, underwent surgical resection of three ribs, plasty with local tissues, and an individual 3D printed titanium implant was installed on the sternum and IV-VI ribs. Follow up for 26 months showed no complaints or signs of recurrence. A 52-year-old woman with radiation-induced soft tissue sarcoma of the chest wall, that developed 9 years after radiation for breast cancer, underwent resection of four ribs and pectoral muscles and a 3D printed titanium implant was installed on the sternum and II-V ribs. The operation was complicated by the marginal necrosis of the soft tissue flap and infection of the endoprosthesis, which required removal of the metal structure and reconstruction using TRAM flap. After 9 months, a local recurrence of the tumor was diagnosed. </p></sec><sec><title>Discussion</title><p>Discussion. As a factor of a positive outcome in a man should be noted a thick layer of subcutaneous fat with muscle tissue, due to which plastic surgery was performed, covering the defect without tension. An extensive resection of the pectoral muscles in a woman created a tissue deficit. Another factor of an unfavorable outcome can be considered the radio-induced nature of the sarcoma. Further research is needed to improve the strategy for selecting patients with malignant tumors of the chest wall for prosthetics.</p></sec></abstract><trans-abstract xml:lang="ru"><p>3D-принтинг открыл новые возможности для разработки индивидуальных систем протезирования обширных дефектов грудной стенки после радикальных хирургических вмешательств по поводу злокачественных опухолей. Однако факторы риска неблагоприятного исхода таких операций до сих пор не определены.</p><sec><title>Описание случаев</title><p>Описание случаев. Мужчине 65 лет по поводу первичной хондросаркомы V ребра выполнена резекция трех ребер, пластика местными тканями, установлен индивидуальный 3D-имплант из титана на грудину и IV–VI ребра. За 26 мес. наблюдения жалоб нет, признаков рецидива не отмечено. Женщине 52 лет по поводу радиоиндуцированной саркомы мягких тканей грудной стенки, развившейся через 9 лет после облучения по поводу рака молочной железы, выполнена резекция четырех ребер и грудных мышц, установлен 3D-имплант из титана на грудину и II–V ребра. Операция осложнилась развитием краевого некроза лоскута мягких тканей, инфицированием эндопротеза, что привело к необходимости удаления металлоконструкции и пластики дефекта TRAM-лоскутом. Через 9 месяцев диагностирован местный рецидив опухоли.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Фактором положительного исхода у мужчины необходимо отметить толстый слой подкожножировой клетчатки с мышечной тканью, за счет которого выполнена пластика, укрывшая дефект без натяжения. Обширная резекция грудных мышц у женщины создала дефицит тканей. Другим фактором неблагоприятного исхода можно рассматривать радиоиндуцированный характер саркомы. Необходимы дальнейшие исследования по улучшению стратегии отбора пациентов со злокачественными опухолями грудной стенки для проведения протезирования.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>3D-принтинг</kwd><kwd>индивидуальный имплант</kwd><kwd>аддитивные технологии</kwd><kwd>титановый имплант</kwd><kwd>хондросаркома ребра</kwd><kwd>радиоиндуцированная саркома мягких тканей</kwd></kwd-group><kwd-group xml:lang="en"><kwd>3D printing</kwd><kwd>individual implant</kwd><kwd>additive technologies</kwd><kwd>titanium implant</kwd><kwd>chondrosarcoma of the rib</kwd><kwd>radiation-induced soft tissue sarcoma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cipriano A., Burfeind W. Jr. Management of primary soft tissue tumors of the chest wall. Thorac Surg Clin. 2017 May; 27(2): 139–147. https://doi.org/10.1016/j.thorsurg.2017.01.007. 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