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Sechenov Medical Journal

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Bioresorbable collagen materials in surgery: 50 years of success

https://doi.org/10.47093/2218-7332.2020.11.1.59-70

Abstract

Collagen materials are widely applied in medicine due to optimal handling characteristics, biocompatibility, controlled biodegradation, the ability to form complexes with drugs and facilitate regeneration. Researchers from Sechenov University developed, studied in experiments and introduced into medicine a variety of materials based on collagen — a protein of connective tissue. At the same time, new collagen materials were launched into clinical practice abroad. In this review of Russian and world literature, we described how scientific and applied studies of collagen materials developed over time and tried to illustrate the current state and trends of collagen application for a variety of medical purposes — from hemostatic sponges to tissue-engineered constructs. The range of available collagen-based medical products and the emergence of new collagen materials indicate the keen interest in this biomaterial from the medical community and the potential of future discoveries.

About the Authors

A. L. Fayzullin
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexey L. Fayzullin, Junior research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991
Tel.: +7 (917) 587-88-31 



A. B. Shekhter
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anatoly B. Shekhter, Professor, MD, PhD, DMSc, Head of the Laboratory of experimental morphology, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



L. P. Istranov
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Leonid P. Istranov, Professor, PhD, DSc, Principal research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



E. V. Istranova
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena V. Istranova, PhD, Leading research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



T. G. Rudenko
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Tatyana G. Rudenko, MD, PhD, Leading research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



A. E. Guller
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anna E. Guller, PhD, Senior research fellow, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



R. K. Aboyants
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Ruben K. Aboyants, MD, PhD, engineer, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



P. S. Timashev
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Petr S. Timashev, PhD, DSc, Director, Institute for Regenerative Medicine

8/2, Trubetskaya str., Moscow, 119991



D. V. Butnaru
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Denis V. Butnaru, MD, PhD, Vice-rector for Research and Public Relations

8/2, Trubetskaya str., Moscow, 119991



References

1. Khil’kin A.M., Shekhter A.B., Istranov L.P., Lemenev V.L. Kollagen i ego primenenie v meditsine [Collagen and its application in medicine]. Moscow: Meditsina, 1976. 228 p. (In Russian).

2. Shekhter A.B., Guller A.E., Istranov L.P., et al. Morfologiia kollagenovykh matriksov dlia tkanevoi inzhenerii (biosovmestimost’, biodegradatsiia, tkanevaia reaktsiia) [Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue reaction)]. Arkh Patol. 2015; 77(6): 29–38 (In Russian). https://doi.org/10.17116/patol201577629-38

3. Istranov L.P., Shekhter A.B., Belova L.A. Elektronno-mikroskopicheskie issledovaniia fibrill fermentorastvorennogo kollagena [Electron microscopic studies of fibrils of fermented collagen]. Biophysics. 1976; 21: 578–9 (In Russian).

4. Sychenikov I.A., Shekhter A.B., Dronov A.F. Kollagenoplastika. Dostizheniia i perspektivy [Collagenoplasty. Achievements and prospects]. Eksperimental’naia khirurgiia. 1974: 25–31 (In Russian).

5. Sychenikov I.A., Aboiants R.K., Dronov A.F., et al. Kollagenoplastika v meditsine [Collagenoplasty in medicine]. Moscow: Meditsina, 1978 (In Russian).

6. Istranova E.V., Aboiants R.K., Istranov L.P. Antimikrobnaia aktivnost’ kollagenovykh gubok [Antimicrobial activity of collagen sponges]. Farmatsiia. 2011; 1: 34–7 (In Russian).

7. Shekhter A.B., Istranov L.P. Sovremennye predstavleniia o strukture kollagena [Modern understanding of the structure of collagen]. Arkh Patol. 1970; 32(7): 3–20 (In Russian).

8. Serov V.V., Shekhter A.B. Soedinitel’naia tkan’: funktsional’naia morfologiia i obshchaia patologiia [Connective tissue: functional morphology and general pathology]. Moscow: Meditsina, 1981 (In Russian).

9. Shtil’man M.I. Tekhnologiia polimerov mediko-biologicheskogo naznacheniia. Polimery prirodnogo proiskhozhdeniia. [Biomedical polymer technology. Natural polymers.] Moscow: Binom Laboratoriia znanii, 2015. (In Russian).

10. Istranova E.V., Istranov L.P., Grishchenko S.V. Farmatsevticheskii analiz preparatov na osnove kollagena [Collagen based pharmaceutical analysis]. Farmatsiia. 1986; 1: 22–4 (In Russian).

11. Glybochko P.V., Aliaev Iu.G., Shekhter A.B., et al. Eksperimental’noe obosnovanie sozdaniia gibridnoi matritsy i tkaneinzhenernoi konstruktsii na osnove setki iz poliglikolida i rekonstruirovannogo kollagena s tsel’iu posleduiushchei zamestitel’noi uretroplastiki [PLGA mesh-collagen hybrid scaffold and tissue-engineered product in substitution urethroplasty: experimental validation]. Urologiia. 2015; 6: 5–13 (In Russian).

12. Dronov A., Rudenko T., Arutunova V. Collagen-minomycin c plex. Antibiotics (Basel). 1977; 3: 283–6.

13. Shekhter A., Rudenko T., Istranov L., et al. Dinitrosyl iron c plexes with glutathione incorporated into a collagen matrix as a base for the design of drugs accelerating skin wound healing. Eur J Pharm Sci. 2015; 78: 8–18. https://doi.org/10.1016/j.ejps.2015.06.002

14. Shekhter A., Berchenko G., Nikolaev A. Macrophage-fibroblast i teraction and its possible role in the regulation of collagen metabolism during wound healing. Bull Exp Biol Med 1977; 83: 745–8.

15. Sychenikov I.A., Nikolaev A.V., Shekhter A.B. Lechenie ran k lagenovymi preparatami. [Collagen treatment of wounds.] Khirurgiia. 1979; 3: 31–8 (In Russian).

16. Kantemirova B.F., Shekhter A.B. Primenenie kollagenovykh pokrytiy pri lechenii glubokikh ozhogovykh ran kozhi [Application of collagen coatings in the treatment of deep burn wounds of the skin]. Vestnik Akadmednauk SSSR. 1975; 7: 82–5 (In Russian).

17. Khil’kin A.M., Shekhter A.B., Lemenev V.L., Dronov A.F. L nie skal’pirovannykh ran i ozhogov kozhi kollagenovymi plenkami v eksperimente [Treatment of scalped wounds and skin burns with collagen films in experiment]. Eksperimental’naia khirurgiia. 1972; 6: 37–41 (In Russian).

18. Berchenko G.N., Shekhter A.B., Nikolaev A.V., et al. Osobennosti zazhivleniia gnoinykh ran u bol’nykh pri lechenii kollagenovymi preparatami (gistokhimicheskoe i elektronno-mikroskopicheskoe issledovanie) [Features of healing of purulent wounds in patients treated with collagen preparations (histochemical and electron microscopic examination)]. Arkh Patol. 1985; 12: 37–44 (In Russian).

19. Ermolov A.S., Smirnov S.V., Khvatov V.B., et al. Biologicheskaia poviazka dlia lecheniia ozhogovykh ran IIIa stepeni [Biological dressing for the treatment of IIIa degree burn wounds]. Khirurgiia. 2008; 10: 4–9 (In Russian).

20. Iumashev G.S., Nikolaev A.V., Shekhter A.B., Kazbekova P.N. Primenenie kollagenovoi gubki pri lechenii prolezhnei [Collagen sponge in the treatment of pressure ulcers]. Ortopediia i travmatologiia. 1978; 12: 36 (In Russian).

21. Istranov L.P., Aboyants R.K., Belozerskaia G.G., et al. Mestnye gemostaticheskie sredstva na osnove kollagena [Collagen-based local hemostatic agents]. Farmatsiia. 2007; 7: 29–32 (In Russian).

22. Khubutiya M., Klukvin I., Istranov L., et al. Stimulation of Regeneration of Hyaline Cartilage in Experimental Osteochondral Injury. Bull Exp Biol Med. 2008; 146(5): 658–61. https://doi.org/10.1007/s10517-009-0356-y

23. Aboiants R.K., Istranov L.P., Shekhter A.B., et al. Gapkol — novyi osteoplasticheskii material [Gapkol — a new osteoplastic material]. Stomatologiia. 1996; 5: 23–5 (In Russian).

24. Krashennikova M.M., Shekhter A.B. Primenenie kollagena pri vital’noi amputatsii pul’py zuba v eksperimente [The use of collagen in vital tooth pulp amputation in experiment]. Stomatologiia. 1973; 2: 1–4 (In Russian).

25. Preobrazhenskii N.A., Gol’dman I.I., Shekhter A.B. Primenenie kollagena v rekonstruktivnoi khirurgii srednego ukha [Collagen applications in middle ear reconstructive surgery]. Vestn Otorinolaringol. 1973; 6: 57–62 (In Russian).

26. Levchik E., Aboianc R., Istranov L., Rudenko T. External p tion of the intestine anastomoses by collagen explants. Immunol Lett. 1997; 1(56): 490.

27. Sychenikov I.A., Nikolaev A.V., Shekhter A.B., Rudenko T.G. Antibakterial’nye sosudistye protezy s antikoaguliantnym svoistvami i primenenie ikh v usloviiakh infitsirovannoi rany [Antibacterial vascular prostheses with anticoagulant properties and their use in conditions of an infected wound]. Grudnaia khirurgiia. 1977; 6: 36–41 (In Russian).

28. Berchenko G.N., Shekhter A.B., Nikolaev A.V., et al. Osobennosti zazhivleniia gnoinykh ran u bol’nykh pri lechenii kollagenovymi preparatami (gistokhimicheskoe i elektronnomikroskopicheskoe issledovanie) [Features of healing of purulent wounds in patients treated with collagen preparations (histochemical and electron microscopic examination)]. Arkh Patol. 1985; 12: 37–44 (In Russian).

29. Vaisov A.S., Dronov A.F., Istranov L.P., Rudenko T.G. Primenenie kollagenovykh preparatov pri lechenii kozhnykh ran [The use of collagen preparations in the treatment of skin wounds]. Med Zh Uzb. 1975; 8: 56–64 (In Russian).

30. Malinin V.V., Burakova M.A., Sidorova N.D., et al. Collagen sponge “cytothymacol”: A wound-healing stimulator. Pharm Chem J. 1998; 32: 622–4. https://doi.org/10.1007/BF02465842

31. Bardakova K.N., Grebenik E.A., Istranova E.V., et al. Reinforced Hybrid Collagen Sponges for Tissue Engineering. Bull Exp Biol Med. 2018; 165(1): 142–7. https://doi.org/10.1007/s10517-018-4116-8

32. Kholkhoev B., Buinov A., Makotchenko V., et al. Electrically c ductive composites of collagen and graphene. Russian Chemical Bulletin. 2018; 67(7): 1316–8. https://doi.org/10.1007/s11172-018-2218-0

33. Chailakhyan R.K., Shekhter A.B., Ivannikov S.V., et al. R construction of Ligament and Tendon Defects Using Cell Technologies. Bull Exp Biol Med. 2017; 162(4): 563–8. https://doi.org/10.1007/s10517-017-3660-y

34. Bardakova K.N., Grebenik E.A., Minaev N.V., et al. Tailoring the collagen film structural properties via direct laser cross-linking of star-shaped polylactide for robust scaffold formation. Mater Sci Eng C Mater Biol Appl. 2020; 107: 110300. https://doi.org/10.1016/j.msec.2019.110300

35. Zurina I.M., Shpichka A.I., Saburina I.N., et al. 2D/3D buccal e thelial cell self-assembling as a tool for cell phenotype maintenance and fabrication of multilayered epithelial linings in vitro. Biomed Mater. 2018; 13(5): 054104. https://doi.org/10.1088/1748-605X/aace1c

36. Zurina I.M., Presniakova V.S., Butnaru D.V., et al. Tissue e neering using a combined cell sheet technology and scaffolding approach. Acta Biomater. 2020; S 1742-7061(20)30337-8. https://doi.org/10.1016/j.actbio.2020.06.016

37. Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers [Electronic resource]. URL: https://clinicaltrials.gov/ct2/show/NCT03205670 (accessed 10.05.2019)

38. Guller A.E., Grebenyuk P.N., Shekhter A.B., et al. BioreactorBased Tumor Tissue Engineering. Acta Naturae. 2016; 8(3): 44-58. https://doi.org/10.32607/20758251-2016-8-3-44-58

39. Pappas A., Hyatt G. The evaluation of collagen film applied to skin defects in mice. Surg forum. 1960.

40. McBride C.M., Healey J.E. Jr., Butler J.J., White E.C. Use of collagen cloth for repair of tissue defects. Surg forum. 1964; 15: 70–1.

41. Abbenhaus J.I., Donald P. The use of collagen grafts for r ment of major skin loss. Laryngoscope. 1971; 81(10): 1650–1. https://doi.org/10.1288/00005537-197110000-00010

42. Wanke M., Collins R.L., Hartmann R., et al. Strukturabhängige Wundheilung bei temporärem Hautersatz mit Kollagen-Schaumfolien [Structure dependent wound healing with temporary skin substitute of collagen foam film]. Frankf Z Pathol. 1967; 77(2): 125–34.

43. Morgenstern L. Experimental partial splenectomy: application of cyanoacrylate monomer tissue adhesive for hemostasis. Am Surg. 1965; 31(11): 709–12.

44. Peacock E.E. JR., Seigler H.F., Biggers P.W. Use of tanned collagen sponges in the treatment of liver injuries. Ann Surg. 1965; 161(2): 238–47. https://doi.org/10.1097/00000658-196502000-00013

45. Fagien S. Facial soft-tissue augmentation with injectable a gous and allogeneic human tissue collagen matrix (autologen and dermalogen). Plast Reconstr Surg. 2000; 105(1): 362–75. https://doi.org/10.1097/00006534-200001000-00057

46. Hsu P.W., Salgado C.J., Kent K., et al. Evaluation of porcine dermal collagen (Permacol) used in abdominal wall reconstruction. J Plast Reconstr Aesthet Surg. 2009; 62(11): 1484–9. https://doi.org/10.1016/j.bjps.2008.04.060

47. Veves A., Sheehan P., Pham H.T. A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg. 2002; 137(7): 822–7. https://doi.org/10.1001/archsurg.137.7.822

48. Greenwood J.E., Clausen J., Kavanagh S. Experience with b brane: uses and caveats for success. Eplasty. 2009; 9.

49. Marston W.A., Hanft J., Norwood P., Pollak R. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes care. 2003; 26(6): 1701–5. https://doi.org/10.2337/diacare.26.6.1701

50. Landsman A.S., Cook J., Cook E., et al. A retrospective c cal study of 188 consecutive patients to examine the effectiveness of a biologically active cryopreserved human skin allograft (TheraSkin® ) on the treatment of diabetic foot ulcers and venous leg ulcers. Foot Ankle Spec. 2011; 4(1): 29–41. https://doi.org/10.1177/1938640010387417

51. Davis N.F., Kheradmand F., Creagh T. Injectable biomaterials for the treatment of stress urinary incontinence: their potential and pitfalls as urethral bulking agents. Int Urogynecol J. 2013; 24(6): 913–9. https://doi.org/10.1007/s00192-012-2011-9

52. Maslekar S., Smith K., Harji D., et al. Injectable collagen for the treatment of fecal incontinence: long-term results. Dis Colon Rectum. 2013; 56(3): 354–9. https://doi.org/10.1097/DCR.0b013e3182805276

53. Kimura M., Nito T., Sakakibara K.I., et al. Clinical experience with collagen injection of the vocal fold: a study of 155 patients. Auris Nasus Larynx. 2008; 35(1): 67–75. https://doi.org/10.1016/j.anl.2007.07.005

54. Slater N.J., van der Kolk M., Hendriks T., et al. Biologic grafts for ventral hernia repair: a systematic review. Am J Surg. 2013; 205(2): 220–30. https://doi.org/10.1016/j.amjsurg.2012.05.028

55. Kissane N.A., Itani K.M. A decade of ventral incisional h nia repairs with biologic acellular dermal matrix: what have we learned? Plast Reconstr Surg. 2012; 130(5 Suppl 2): 194S–202S. https://doi.org/10.1097/PRS.0b013e318265a5ec

56. Ibrahim A.M., Ayeni O.A., Hughes K.B., et al. Acellular d mal matrices in breast surgery: a comprehensive review. Ann Plast Surg. 2013; 70(6): 732–8. https://doi.org/10.1097/SAP.0b013e31824b3d30

57. Erdogan D., van Gulik T.M. Evolution of f ed collagen patch for use as a topical hemostatic agent. J Biomed Mater Res B Appl Biomater. 2008; 85(1): 272–8. https://doi.org/10.1002/jbm.b.30916

58. Chang W.K., Srinivasa S., MacCormick A.D., Hill A.G. G cin-collagen implants to reduce surgical site infection: systematic review and meta-analysis of randomized trials. Ann Surg. 2013; 258(1): 59–65. https://doi.org/10.1097/sla.0b013e3182895b8c

59. Creanor S., Barton A., Marchbank A. Effectiveness of a g cin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials. Ann R Coll Surg Engl. 2012; 94(4): 227–31. https://doi.org/10.1308/003588412X13171221590179

60. Hussain S.T. Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection following vascular surgery. Int J Surg. 2012; 10 Suppl 1: 5–9. https://doi.org/10.1016/j.ijsu.2012.05.015

61. de Bruin A.F., Gosselink M.P., van der Harst E. Local a tion of gentamicin-containing collagen implant in the prophylaxis of surgical site infection following gastrointestinal surgery. Int J Surg. 2012; 10 Suppl 1: 21–7. https://doi.org/10.1016/j.ijsu.2012.05.014

62. Knaepler H. Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection in orthopaedic surgery. Int J Surg. 2012; 10 Suppl 1: 15–20. https://doi.org/10.1016/j.ijsu.2012.05.020

63. Narotam P.K., José S., Nathoo N., et al. Collagen matrix ( Gen) in dural repair: analysis of a new modified technique. Spine. 2004; 29(24): 2861–7. https://doi.org/10.1097/01.brs.0000148049.69541.ad

64. Silva J.B., Marchese G., Cauduro C., Debiasi M. Nerve c duits for treating peripheral nerve injuries: A systematic literature review. Hand Surg Rehabil. 2017; 36(2): 71–85. https://doi.org/10.1016/j.hansur.2016.10.212

65. Pabari A., Yang S.Y., Mosahebi A., Seifalian A.M. Recent a vances in artificial nerve conduit design: strategies for the delivery of luminal fillers. J Control Release. 2011; 156(1): 2–10. https://doi.org/10.1016/j.jconrel.2011.07.001

66. Sotome S., Ae K., Okawa A., et al. Efficacy and safety of porous hydroxyapatite/type 1 collagen composite implantation for bone regeneration: a randomized controlled study. J Orthop Sci. 2016; 21(3): 373–80. https://doi.org/10.1016/j.jos.2016.01.007

67. Lee S.W., Kim S.G. Membranes for the guided bone r eration. Maxillofac Plast Reconstr Surg. 2014; 36(6): 239. https://doi.org/10.14402/jkamprs.2014.36.6.239

68. Bourguignon T., Bouquiaux-Stablo A.L., Candolfi P., et al. Very long-term outcomes of the Carpentier-Edwards Perimount valve in aortic position. Ann Thorac Surg. 2015; 99(3): 831–7. https://doi.org/10.1016/j.athoracsur.2014.09.030

69. Sanz-Garcia A., Oliver-de-la-Cruz J., Mirabet V., et al. Heart valve tissue engineering: how far is the bedside from the bench? Expert Rev Mol Med. 2015; 17: e16. https://doi.org/10.1017/erm.2015.15

70. Atala A., Bauer S.B., Soker S., et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006; 367(9518): 1241–6. https://doi.org/10.1016/S0140-6736(06)68438-9

71. Hamilton N.J., Kanani M., Roebuck D.J., et al. Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study. Am J Transplant. 2015; 15(10): 2750–7. https://doi.org/10.1111/ajt.13318

72. Struecker B., Hillebrandt K.H., Raschzok N., et al. Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs. Eur Surg Res. 2016; 56(1–2): 61–75. https://doi.org/10.1159/000441720


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