新型冠状病毒COVID-19全球大流行期间肿瘤患者管理的特点

简介：
直至今日由新型冠状病毒引起的COVID-19在世界各地尚未得到有效控制。定期刊物对感染新型冠状病毒的肿瘤患者发生严重并发症的高风险常有报道。综述信息来源于文献材料，以国外临床同僚的临床实例为基础，介绍了在克服这一疾病及其后果方面获得的经验，同时也引入了俄罗斯卫生部国家放射医学研究中心在俄罗斯肿瘤学家协会和肿瘤学健康组织者协会的参与和支持下所提出的关于COVID-19大流行期间肿瘤性疾病治疗的指导性意见。这些信息整合了科学文献电子数据库以及俄语和英语的开放数据平台上收集而来的真实数据。本综述亦引入国际和国内专业界关于癌症患者在新冠肺炎流行期间治疗的路径选择和多学科治疗的建议。

1. World Health Organization Virtual press conference on COVID-19 — 11 March 2020. URL: https://www.who.int/docs/ default-source/coronaviruse/transcripts/who-audio-emergencies-coronavirus-press-conference-full-and-final-11mar2020. pdf?sfvrsn=cb432bb3_2, free (accessed 06.04.2020).

2. Vremennye metodicheskie rekomendatsii Minzdrava Rossii “Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19)”. Versiia 7 (03.06.2020). [Temporary guidelines of the Ministry of health of the Russian Federation “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)”. Version 7 (03.06.2020)]. (In Russian). URL: http://www.consultant.ru/document/cons_doc_LAW_354163/#dst0, free (accessed 06.06.2020).

3. Kamboj M., Sepkowitz K.A. Nosocomial infections in patients with cancer. Lancet Oncol. 2009; 10(6): 589–97. https://doi. org/10.1016/S1470-2045(09)70069-5 PMID: 19482247

4. Liang W. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020; 21(3): 335–7. https://doi. org/10.1016/S1470-2045(20)30096-6 PMID: 32066541

5. ESMO. ESMO COVID-19 and cancer. URL: https://www. esmo.org/covid-19-and-cancer/q-a-on-covid-19, free (accessed 20.04.2020).

6. Gosain R., Abdou Y., Singh A., et al. COVID-19 and cancer: a comprehensive review. current oncology reports 2020 May 8; 22(5): 53. https://doi.org/10.1007/s11912-020-00934-7 PMID: 32385672

7. Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19). 16–24 February 2020. https://www.who.int/ docs/default-source/coronaviruse/who-china-joint-mission-oncovid-19-final-report.pdf, free (accessed 22.03.2020).

8. Yu J., Ouyang W., Chua M.L.K., Xie C. SARS-CoV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China. JAMA Oncol. 2020 Mar 25; 6(7): 1108–10. https://doi. org/10.1001/jamaoncol.2020.0980 PMID: 32211820

9. The Novel Coronavirus Pneumonia Emergency Response Epide miology Team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) — China, 2020. 2020 Feb 10; 41(2): 145–51. https://doi.org/10.3760/cma .j.issn.0254-6450.2020.02.003 PMID: 32064853 URL: https:// slma.lk/wp-content/uploads/2020/02/TheEpidemiologicalChara cteristicsofanOutbreakof2019NovelCoronavirusDiseases28COVID-1929E28094China2C20201.pdf, free (accessed 22.03.2020).

10. Desai A., Sachdeva S., Parekh T., Desai R. COVID-19 and cancer: lessons from a pooled meta-analysis. JCO Glob Oncol. 2020 Apr; 6:557–9. https://doi.org/10.1200/GO.20.00097 PMID: 32250659

11. Emami A., Javanmardi F., Pirbonyeh N., Akbari A. Prevalence of underlying diseases in hospitalized patients with COVID-19: a systematic review and meta-analysis. Arch Acad Emerg Med. 2020 Mar 24; 8(1): e35. eCollection. https://doi.org/10.22037/ aaem.v8i1.600 PMID: 32232218

12. Hu Y., Sun J., Dai Z., et al. Prevalence and severity of corona virus disease 2019 (COVID-19): a systematic review and meta-analysis. J Clin Virol. 2020 Jun; 127: 104371. https://doi.org/10.1016/j. jcv.2020.104371 PMID: 32315817

13. Richardson S., Hirsch J.S., Narasimhan M., et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area. JAMA. 2020 Apr 22; 323(20): 2052–9. https://doi.org/10.1001/ jama.2020.6775 PMID: 32320003

14. Grasselli G., Zangrillo A., Zanella A., et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA. 2020 Apr 6; 323(16): 1574–81. https://doi.org/10.1001/jama.2020.5394 PMID: 32250385

15. Onder G., Rezza G., Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020 Mar 23; 323(18): 1775–6. https://doi.org/10.1001/ jama.2020.4683 PMID: 32203977

16. Verity R., Okell L.C., Dorigatti I., et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020 Jun; 20(6): 669–77. https://doi.org/10.1016/ S1473-3099(20)302 43-7 PMID: 32240634

17. Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020. MMWR Morb Mortal Wkly Rep. ePub: 31 March 2020. 2020 Apr 3; 69(13): 382–6. https://doi.org/10.15585/mmwr.mm6913e2 PMID: 32240123

18. Zhang L., Zhu L., Xie C., et al. Clinical characteristics of COVID19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China. Ann Oncol. 2020 Jul; 31(7): 894–901. https://doi.org/10.1016/j.annonc.2020.03.296 PMID: 32224151

19. Dai M., Liu D., Liu M., et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov. 2020 Jun; 10(6): 783–91. https://doi.org/10.1158/2159-8290.CD-20-0422 PMID: 32345594

20. Miyashita H., Mikami T., Chopra N., et al. Do Patients with cancer have a poorer prognosis of COVID-19? An experience in New York city. Ann Oncol. 2020 Aug; 31(8): 1088–9. https://doi.org/10.1016/j.annonc.2020.04.006 PMID: 32330541

21. Mehta V., Goel S., Kabarriti R., et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov. 2020 Jul; 10(7): 935–41. https://doi.org/10.1158/2159- 8290.CD-20-0516 PMID: 32357994

22. U.S. Food & Drug Administration. FDA drug shortages. URL: https://www.accessdata.fda.gov/scripts/drugshortages/default. cfm, free (accessed 22.03.2020)

23. ASCO. ASCO coronavirus resources. URL: https://www.asco. org/asco-coronavirus-information, free (accessed 17.04.2020).

24. You B., Ravaud A., Canivet A., et al. The official French guidelines to protect patients with cancer against SARS-CoV-2 infection. Lancet Oncol. 2020 May; 21(5): 619–21. https://doi.org/10.1016/ S1470-2045(20)30204-7 PMID: 32220659

25. NCCN. Coronavirus disease 2019 (COVID-19) resources for the cancer care community. URL: https://www.nccn.org/covid-19/, free (accessed 12.04.2020).

26. ESMO. ESMO COVID-19 and cancer. URL: https://www.esmo. org/covid-19-and-cancer, free (accessed 20.04.2020).

27. Ontario Health Cancer Care Ontario. Pandemic planning clinical guideline for patients with cancer. URL: https://www.accc-cancer. org/docs/documents/cancer-program-fundamentals/oh-cco-pandemic-planning-clinical-guideline_final_2020-03-10.pdf, free (accessed 20.04.2020).

28. Al-Shamsi H.O., Alhazzani W., Alhuraiji A., et al. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group. Oncologist. 2020 Jun; 25(6): e936–45. https:// doi.org/10.1634/theoncologist.2020-0213 PMID: 32243668

29. American Society for Radiation Oncology (ASTRO). COVID-19 recommendations to radiation oncology practices. URL: https:// www.astro.org/Daily-Practice/COVID-19-Recommendationsand-Information, free (accessed 10.05.2020).

30. Kaprin A.D., Kostin A.A., Pashigorova L.V., et al. Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19) u onkologicheskikh bol’nykh. Moskva: FGBU “Natsional’nyi meditsinskii issledovatel’skii Tsentr radiologii” Minzdrava Rossii, 2020. 18 р. [Prevention, diagnosis and treatment of new coronavirus infection (COVID-19) in cancer patients]. (In Russian). URL: http://nmicr.ru/news/covid-19/_Covid_брошюра_%20FIN.pdf, (accessed 05.06.2020).

31. Cai Z.X., Wen W.Q., Min Z.J. Comparison of 5–FU-based and capecitabine-based neoadjuvant chemoradiotherapy in patients with rectal cancer: a meta-analysis. Clin Colorectal Cancer. 2017 Sep; 16(3): e123–39. https://doi.org/10.1016/j.clcc.2017.01.009 PMID: 28284574

32. Willan J., King A.J., Hayes S., et al. Care of haematology patients in a COVID-19 epidemic. Br J Haematol. 2020 Apr; 189(2): 241– 3. https://doi.org/10.1111/bjh.16620 PMID: 32173855

33. Centers for Disease Control and Prevention. CDC: COVID-19. URL: https://www.cdc.gov/coronavirus/2019-nCoV/index.html, free (accessed 26.04.2020).

34. American College of Surgeons. ACS: COVID-19 and surgery. URL: https://www.facs.org/covid-19/clinical-guidance, free (accessed 16.04.2020).

35. Liang W., Guan W., Chen R., et al. Cancer patients in SARSCoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020 Mar; 21(3): 335–7. https://doi.org/10.1016/S1470- 2045(20)30096-6 PMID: 32066541

36. COVID-19 rapid guideline: delivery of systemic anticancer treatments NICE guideline [NG161] Published date: 20 March 2020. Last updated: 27 April 2020. URL: https://www.nice.org.uk/ guidance/ng161/resources/covid19-rapid-guideline-delivery-ofsystemic-anticancer-treatments-pdf-66141895710661, free (accessed 05.05.2020).

37. Interim treatment change options for the COVID-19 pandemic, endorsed by NHS England (27 April 2020). URL: https://www. nice.org.uk/guidance/ng161/resources/interim-treatment-changeoptions-during-the-covid19-pandemic-endorsed-by-nhs-englandpdf-8715724381, free (accessed 10.05.2020).

38. Chua M.L.K. Effektivnyi onkotsentr v epokhu COVID: opyt Kitaia i Singapura [Effective cancer centers in the age of COVID: the experience of China and Singapore]. (In Russian). URL: http://www.protiv-raka.ru/effektivnyj-onkocentr-v-epohu-covidopyt-kitaya-i-singapura/, free (accessed 28.04.2020).

39. Snegovoi A.V., Kononenko I.B., Kornietskaia A.L. i dr. Rekomendatsii po profilaktike i lecheniiu neitropenii i anemii u onkopatsientov v period pandemii COVID-19 [Recommendations for the prevention and treatment of neutropenia and anemia in cancer patients during the COVID-19 pandemic]. (In Russian). URL: https://oncology-association.ru/files/pdf/2020/Rekomendacii_ AOR_po_FN_i_anemii.pdf, free (accessed 10.06.2020).