CLINICAL SIGNIFICANCE OF ANEMIA IN PATIENTS WITH CHRONIC HEART FAILURE

Abstract

Aim of the study. Evaluation of influence of anemia of various severity of central hemodynamics parameters in patients with chronic heart failure.
Methods. 60 patients with chronic heart failure and anemia (age 72,3+9,0 years) were included into the study. Hemoglobin level was 36-112 g/1. Echocardiography was performed in all patients in the 1st and 26th days of hospitalization. In all patients hemoglobin level, erythrocyte count, erythrocyte indices (MCH, MCV), hematocrit level and serum iron concentration were determined.
Results. All patients were divided into 2 group: 1st with hemoglobin level <70 g/1, 2nd - with hemoglobin level >70 g/1. Median hemoglobin level was 52,8+11,0 g/1 in 1st group and 91,0± 12,9 g/1 in 2nd group (p<0,01 ). Patients with more severe anemia had higher values of myocardial contractile parameters: left ventricular ejection fraction (LVEF) was 70,6±13,2%, stroke volume (SV) - 75,0+17,5 ml. In group with less severe anemia LVEF was 41,0+6,3%, SV - 37,8+4,3 ml. After complex treatment of anemia and chronic heart failure in 1st group LVEF (70,6± 13,2 and 55,6+8,0%; /?<0,01) and SV (75,0± 17,5 and 58,3+11,3 ml; p<0,05) decreased. In 1st group treatment did not result in sighnificant changes of LVEF and SV.
Conclusion. Severe anemia in patients with chronic heart failure promotes reversible remodeling of central hemodynamics in hyperkinetic type, less severe anemia does not influence significantly the systolic parameters of left ventricle.