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Gonadotropin dependent premature pubertal development in girls. Description of clinical cases

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Abstract

Precocious puberty (PP) is one of the most common abnormalities of pubertal development in children. Typical PP features are: accelerated physical development, premature development of secondary sexual characteristics, early growth plates closure and formation of short stature in adult age. The article tempts to demonstrate the importance of early diagnostics of true PP in girls, the basic principles of treatment and dispensary observation. We have analyzed two clinical cases where both patients had idiopathic gonadotropin dependent PP, the diagnosis was defined at the same age, but the duration of the disease at the time of diagnosis was different. The patients received therapy with long-acting analogues of luteinizing releasing hormone, the effectiveness of therapy was confirmed by clinical and laboratory tests. Timely started treatment to our patients contributed to the normalization of the growth forecast.

About the Authors

A. V. Vitebskaya
I.M. Sechenov First MSMU (Sechenov University)
Russian Federation


J. R. Amshinskaya
I.M. Sechenov First MSMU (Sechenov University)
Russian Federation


O. V. Shuminov
I.M. Sechenov First MSMU (Sechenov University)
Russian Federation


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10. Дедов И.И., Петеркова В.А. Справочник детского эндокринолога. М.: Литтера; 2014: 496

11. Дедов И.И., Семичева Т.В., Петеркова В.А. Половое развитие детей: норма и патология. М.: Колор Ит Студио; 2002: 232

12. Брук Ч.Г.Д., Браун Р.С. Руководство по детской эндокринологии. М.: ГЭОТАР-Медиа; 2009: 341

13. Дедов И.И., Петеркова В.А. Федеральные клинические рекомендации (протоколы) по ведению детей с эндокринными заболеваниями. М.: Практика; 2014: 442

14. Tanner J.M. Whitehouse RH Clinical longitudinal standards for height, height velocity, and weight velocity and the stages of puberty. Arch. Dis. Child. 1976; 51: 170-179

15. WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards based on length/height, weight and age. Acta. Pediatr. Suppl. 2006; 450: 76-85

16. Greulich W.W., Pyle S. Radiographic atlas of skeleton development of the hand and the wrist. 2nd ed. Stanford: Stanford Univ. Press; 1979: 272

17. Bayley N., Pinneau S.R. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J. Pediatr. 1952; 40: 32-441

18. Петеркова В.А., Витебская А.В., Геппе Н.А. и др. Справочник педиатра по детской эндокринологии: Методическое пособие. М.: Верди; 2016: 140


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)