Sechenov Medical Journal

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No 1 (2017)
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4-9 416
The review goal. to analyze the prospects of regenerative medicine in dentistry Materials. Repin V.S., Rzhaninova A.A., Shamenkov D.A. “Embryonic stem cells: fundamental biology and medicine” (Moscow, 2002), relevant papers from PubMed (MeSH). Conclusion. Regenerative medicine is one of promising areas of modern medicine: in dentistry, for example, various stem cells (e.g., stem cells of bone marrow, stem cells of adipose tissue, and others) can be used to regenerate tissue defects. Moreover, dental stem cells (e.g., dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla) can be used to regenerate nervous tissue, myocardium, cartilages, liver, pancreas. The antiviral therapy with third molars stem cells can prevent cell malignization, in particular hepatic cells. However it is necessary to keep in mind possible adverse effect of regenerative treatment itself.
10-19 581
Idiopathic arrhythmias are heart rhythm and conduction abnormalities in patients without structural heart abnormalities, or more precisely, arrhythmias with unknown causes. However, a complex examination of the patient reveals the cause of arrhythmia in more than 94% cases. A patient, 28, with complains of palpitations, was referred to our clinic with a diagnosis of “idiopathic premature ventricular contractions”. The 24-hour ECG monitoring detected 14326 premature ventricular contractions. The standard clinical tests did not reveal the cause of arrhythmia. Further diagnostic evaluation was focused on verification/exclusion of congenital cardiomyopathies and chronic myocarditis. The heart MRI revealed significant right ventricular dilatation and regional dyskinesia. The signal averaged ECG found late potentials. Thus, there are at least 1 major and 2 minor criteria of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) according to the modified 2010Task Force Criteria. In addition, a concomitant chronic immune myocarditis was diagnosed, which is typical for ARVD. This diagnosis was based on triple elevated titers of anti-heart antibodies and late enhancement revealed by magnetic resonance imaging. Consequently, idiopathic arrhythmias in young patients should not be considered a final diagnosis, but should be a signal for further careful clinical evaluation.
20-25 333
Pulmonary and pleura damage are one of the most common postoperative complications. The prevalence of pulmonary dysfunction following cardiac surgery is 76%. The risk factors are: preoperative respiratory disease, body mass index over 30 kg/m2, intraoperational heart ice encasing, duration of cardiopulmonary bypass period. From a heart surgeon and pathophysiologist prospective, the paper discusses the mechanisms of lung tissue destruction and patient preparation to reduce the incidence and/severity of complications. The data analysis suggests that this factors should be accounted for when planning the operation to reduce the risk of life-threatening complications.
26-31 279
Blood loss 300 ml does not cause significant hemodynamic disorders, however, at the level of the microvasculature, there is an increase in the number of blood cells moving at a slow speed. The most pronounced changes take place when the amount of donated blood is up to 500 ml, revealing a distinct upward trend. The increased linear and volumetric blood flow rate parameters fluctuated with upward trend. Indices of blood flow demonstrated multidirectional dynamics: the ripple index and the index of peripheral resistance showed a downward trend, the index of arterial stenosis showed an upward trend. The values were measured with “Minimax-Doppler-K” device developed and tested in the Institute of Biomedical Problems of the RAS.
32-35 410
The premature membranes rupture in a term pregnancy is an important problem of modern obstetrics. Until now, there is no consensus on cause of premature membranes rupture. Our findings suggest higher prevalence of premature membrane rupture in women with complicated pregnancies.
36-40 550
Precocious puberty (PP) is one of the most common abnormalities of pubertal development in children. Typical PP features are: accelerated physical development, premature development of secondary sexual characteristics, early growth plates closure and formation of short stature in adult age. The article tempts to demonstrate the importance of early diagnostics of true PP in girls, the basic principles of treatment and dispensary observation. We have analyzed two clinical cases where both patients had idiopathic gonadotropin dependent PP, the diagnosis was defined at the same age, but the duration of the disease at the time of diagnosis was different. The patients received therapy with long-acting analogues of luteinizing releasing hormone, the effectiveness of therapy was confirmed by clinical and laboratory tests. Timely started treatment to our patients contributed to the normalization of the growth forecast.
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Breastfeeding remains relevant in the 21st century. The current research into its unique properties attracted increased attention to breastmilk. This paper reviews the Lancet article “Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect” (Lancet, 2016). The review dwells upon breastfeeding international epidemiology; breastfeeding effect on maternal and child outcomes from the evidence based medicine prospective; the possible decrease in the number of preventable maternal and child deaths if breastfeeding practice is scaled up to conditionally optimal level.

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One of the most important areas of health promotion is the stimulation of positive changes in people's behavior and lifestyle. It is time to join the efforts of various specialists in health schools (in individual and public health management programs) to maintain individual physical, mental, social and spiritual well-being. Realizing the importance of psychology in the prevention of non-communicable diseases, the Ministry of Healthcare of the Russian Federation decided to create multidisciplinary rehabilitation teams, which should include medical psychologists. In the article Doctor of Psychological Sciences, N.D. Tvorogova, who researched into various aspects of health psychology for several decades, shares the results of her theoretical and empirical studies.
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The article discusses the incidence forecast on the example of respiratory diseases in children in Nizhny Novgorod. The study used the official statistics of the respiratory diseases prevalence in children of 0-14 age group in 2001-2015. Prediction analysis was based on the trend lines, which displayed the functions from the mean values of the analyzed indicators. The function selection was determined by the temporal data changes. The trend calculation involves three stages: data entry into an Excel spreadsheet, plotting a graph, the selection of a trend line parameters. Then a function is selected that approximates the correlation The choice of the function is determined by the highest determination coefficient (not less than 0,5000). The correlation in question was best approximated by a second-de gree polynomial interpolation. The trend line determination coefficient in this case was 0,9292. The predictive accuracy, that was determined as the mean absolute percentage error (MAPE), was 3%. The predictive accuracy based on a second-degree polynomial interpolation was 97%, which is very high. The found correlation was used in 3-year forecast. Mathematical techniques and informational technologies can significantly improve the quality of care. The information technology becomes one of the leading factors in healthcare development. However, mathematical models and computational algorithms for monitoring, predicting incidence, spread and prevention of various nosologies are still to be developed.

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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)