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THE IMPACT OF CARDIOVASCULAR AND BRONCHOPULMONARY DISEASES ON COENZYME Q10 PLASMA CONCENTRATION

https://doi.org/10.47093/22187332.2019.1.16-21

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Abstract

Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the body.The aim of research is to monitor the relationship between cardiovascular and pulmonary diseases, and the concentration of coenzyme Q10 in the blood plasma.Materials and methods. Coenzyme Q10 was determined using high performance liquid chromatography with mass spectrometric detection.Results and discussion. During the study, it was found that the concentration of coenzyme Q10 in plasma is affected not only by the main diseases, but also by comorbidities, as well as by the therapy. A sharp decrease in plasma coenzyme Q10 concentration was noted in patients with cardiovascular pathologies, especially in those with concomitant endocrine diseases. Also, it was recorded a decrease in the concentration of coenzyme Q10 in the plasma of patients with pneumonia. Conclusion. During the experiment, the coenzyme Q10 concentration was found to be dependent on cardiovascular and pulmonary diseases.

About the Authors

V. I. Zozina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


E. S. Melnikov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


L. M. Krasnykh
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


O. A. Goroshko
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


V. G. Kukes
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)