Sechenov Medical Journal

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Vol 10, No 1 (2019)
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5-10 325
Angina pectoris is a chronic disabling heart disease that leads to myocardial infarction and death without proper treatment. Aim - to study the dynamics of frequency of ambulance сalls for patients with stable angina in different seasons of the year, depending on the current meteorological factors.Materials and methods. 1034 cases of calls of the emergency medical service in the city of Vladikavkaz to the patients with angina attack were analyzed. Based on the seasonal ranking of the ambulance frequency calls and the corresponding base of meteorological parameters, a correlation analysis of the relationship between these indicators was made. Results. It has been established that the seasonality factor influences the frequency of calls to the ambulance (2=9.12; KW-H=8.92). Correlations between the frequency of calls to the ambulance and meteorological factors are seasonally specific and vary with respect to annual coefficients. The most significant contribution to the increase in the incidence of angina attacks is made by the factors: average daily air temperature, inter - day variability of atmospheric pressure, relative humidity, cloudiness, pathogen indices of these factors, as well as a general index of weather pathogenicity.Conclusion. In winter, due to the negative impact of low temperatures and sharp variations in the whole complex of meteorological factors, the maximum number of ambulance calls to patients with angina is recorded. The most favorable period for patients suffering from angina pectoris is the summer season, during which emergency medical care is minimal.
11-15 418
The article discusses the first results of studies of coping strategies of servicemen of the structure of Rosgvardia.The purpose of the study was to study the specifics and to analyze the coping strategies of the rank and file and the command structure of mobile special forces units (OMON) of the Federal service of troops Rosgvardia.Materials and methods. Underwent questionnaire survey 65 members of OMON of the Federal service troops Rosgvardia. The working activity of the presented group of people is associated with the frequent impact of stress factors. The questionnaire of coping with stress in adaptation of Rasskazova-Gordeeva-Aspen was used as a method. Results. After analyzing the data, we determined the frequency of choice of riot police coping strategies in difficult or problematic situations for them. Conclusion. The data collected can be useful for the development of rehabilitation programmes for military personnel, as well as help to expand the database of existing data in the study of coping strategies.
16-21 563
Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the body.The aim of research is to monitor the relationship between cardiovascular and pulmonary diseases, and the concentration of coenzyme Q10 in the blood plasma.Materials and methods. Coenzyme Q10 was determined using high performance liquid chromatography with mass spectrometric detection.Results and discussion. During the study, it was found that the concentration of coenzyme Q10 in plasma is affected not only by the main diseases, but also by comorbidities, as well as by the therapy. A sharp decrease in plasma coenzyme Q10 concentration was noted in patients with cardiovascular pathologies, especially in those with concomitant endocrine diseases. Also, it was recorded a decrease in the concentration of coenzyme Q10 in the plasma of patients with pneumonia. Conclusion. During the experiment, the coenzyme Q10 concentration was found to be dependent on cardiovascular and pulmonary diseases.
22-28 348
The aim - to establish the main pharmacokinetic parameters of 11-deoxyimisoprostol after intragastric administration. Materials and methods. The experiments were performed on 410 white outbred rats - females weighing 180-220 g. 11-deoxymysoprostol was administered to rats intragastrally at a dose of 2.0 mg/kg. Blood and organs were taken for examination at 6, 12, 15, 30 minutes and hourly for 12 hours after administration. After these intervals, the concentration of the drug in the blood and tissue homogenates of laboratory animals was determined, and in the urine - every hour during the day. Chromatographic separation was carried out using a liquid chromatograph (Shimadzu, Japan LC-20 PROMI- NENCE with a diode - array detector SPD-20A).Results. 11-deoxyimisoprostol is rapidly absorbed from the gastrointestinal tract. The maximum (6.625 μg/ml) of the compound in the blood plasma is reached 15 minutes after intragastric administration. When this occurs, a simultaneous in - crease in the concentration of the metabolite - 11-deoxyimisoprostolic acid. The maximum concentration (23.547 µg/ml) of the metabolite in the blood plasma is reached 30 minutes after the administration of 11-deoxyimisoprostol. 11-deoxyimisoprostol is intensively distributed throughout the organs and tissues, while the compound has the highest affinity for myometrium and liver. The smallest quantities of the test substance were found in the lungs, the brain, and the omentum. The active metabolite of 11-deoxyimisoprostol is intensively distributed in organs and tissues, while in the greatest amounts it was detected in the myometrium and the liver and kidneys. The smallest quantities of the test substance were found in the lungs, the brain, and the omentum. In the urine, 11-deoxyimisoprostolic acid is determined during the first days of the study, with a maximum clearance of 6-8 hours after administration.Conclusion. 11-deoxyimisoprostol has a short half - life after intragastric administration (T1/2=0,550 h), which indicates the absence of cumulative properties. The nature of the pharmacokinetic curve is monoexponential.
29-34 332
A complex of diagnostic and therapeutic measures had been established in order to overcome many different causes of female infertility and restore women’s reproductive health.The aim of research is to determine value of immunohistochemical method in determination of disregenerative condition of endometrium in patients undergoing in - vitro fertilization (IVF) program. Materials and methods. The research included 62 patients treated according to IVF program in Clinic of FSBI HPE KSMU NOH Russia, Krasnodar city, in 2017 year. Data of history of disease, laboratory diagnostics, hormonal monitoring at 2-3 day of menstrual cycle and dynamic ultrasound investigation were processed. To evaluate urogenital microbiocenosis real - time PCR was used with “Femoflor-16” kit. Pipelle - biopsy of endometrium was taken at 22-24 day of menstrual cycle. Results. After certain investigation patients were divided into three groups. First group consisted of 18 (29.03%) women with primary infertility, second group - 17 (27.42%) patients with secondary infertility, third group - 27 (43.55%) women with recurrent pregnancy loss. Absence of secretory transformation had been revealed in 27.7% women with primary infertility. In patients with secondary infertility and recurrent pregnancy loss proliferative disorders were less frequent, in11.8 and 7.4% respectively. Immunohistochemistry showed that recurrent pregnancy loss was not associated with impairment of both estrogen and progesterone receptors expression, unlike patients with primary and secondary infertility. In patients with recurrent pregnancy loss increased by 2.9 times collagen growth in endometrial stroma was detected. Conclusion. Addition of immunohistochemistry to routine histological investigation allows detection of impaired cyclic endometrial transformations during window of transformation which prevents successful implantation of blastocyst and pregnancy progression.
35-40 400
The article analyzes the impact of chronic obstructive pulmonary disease (COPD) on the quality of life of patients according to the results of clinical and instrumental examination and ante - testing using the integral CAT-test.Objective. Study of the effect of COPD on the quality of life in outpatient practice based on the results of the integral CAT-test. Materials and methods. The article analyzes the impact of chronic obstructive pulmonary disease (COPD) on the quality of life of patients according to the results of clinical and instrumental examination and ante - testing using the integral CAT-test.Results. The primary treatment of patients with a long history of COPD in stages II and III recorded a greater impact of the respiratory component on the quality of life. Because of complex therapy (inhaled bronchodilators and glucocorticosteroids, antibiotics according to indications, non - pharmacological methods of pulmonary rehabilitation, respiratory gymnastics, and school for patients with COPD) during 1 year of follow - up, there were significant changes in the indicators of quality of life. In patients with the sum of scores on the SAT-test up to 20 showed a decrease in the number and severity of clinical symptoms of respiratory status, and the average value of forced expiratory volume in 1 s (FEV1) remained almost at the same level with a significant improvement in the overall quality of life. In patients with a score of 21 or higher, the FEV1 level after 1 year significantly increased by 12.2%, which is apparently due to a higher level of patient compliance and the effect of pulmonary rehabilitation measures.Conclusion. The results of assessing the impact of different stages of COPD on the quality of life of patients in outpatient practice will improve the monitoring of the course of the disease and optimize the prognosis, state the effectiveness of complex therapy and adjust the dispensary observation plan.
41-46 316
The aim of research - to identify the features of the biomechanical parameters of the arteries of the brain in the II period of adulthood. Materials and methods. The samples of anterior (ACA), middle (MCA), posterior cerebral (PCA), posterior connective (PCoA), basilar arteries (BA) and intracranial parts of vertebral arteries (VA) seized at autopsy of 40 corpses of men andwomen aged 35-60 years were studied. In the longitudinal tension experiment on the tensile testing machine Tira Test studied the overall strength, tensile strength, maximum relative deformation and young's modulus of walls.Results. The paper describes the average values and variability parameters of the studied biomechanical parameters of arteries. The results of the comparative analysis with the average values typical for the population of adults aged 21-90 years are presented. Conclusion. Biomechanical properties of cerebral arteries are characterized by significant variability. The least changeable is the overall strength of the artery wall. The data obtained differ from the average values typical for the population of adults aged 21-90 years. The greatest differences were found for the ultimate strength of the vascular wall. In the II period of adulthood, this parameter in MCA, PCA, BA, ACA and BA is 8-15% more, and in PCoA is 22% less than the average value.
47-51 1407
Aim - to identify the features of the anatomical structure of the muscles acting on the hip joint in the fetal period of prenatal ontogenesis. Material and methods. The study was carried out on corpses of 200 fetuses aged from 12th to 38th weeks. Anatomical and morphometric research methods were used. Results. As a result of the study, it was established that the muscles of the pelvis and thigh of the fetus are different from the definitive ones: more heads are noted, a different direction of force action vector, functional indicators of the extensor and rotator muscles prevail. There are critical periods of organogenesis of functional muscle groups. Conclusions. The main trend of organogenesis of the muscles of the pelvis and thigh is the fusion of small muscle insertions into larger organs. A feature of the fetal muscles acting on the hip joint is the morpho - functional predominance of the insteps and adductor muscles that create the necessary conditions for the hip joint morphogenesis. The 20th-22th and 28th-30th weeks of intrauterine development are critical periods in human hip joint morphogenesis.
52-56 433
Objective - to study the clinical features of community - acquired pneumonia in children of Rostov - on - Don. Materials and methods. To achieve this goal, 261 cases of children aged 1 month to 17 years who were admitted to the hospital with suspected community - acquired pneumonia were analyzed. All patients underwent a thorough analysis of anamnestic data, the results of clinical examination of patients, laboratory diagnostics, and X-ray chest examination. Results. The study showed that the highest incidence of community - acquired pneumonia was observed in children aged 8 to 12 years. Boys get sick more often than girls. More often, pulmonary parenchyma lesions were observed, localized on the right side of 66%, while the bilateral process was registered only in 10%. According to the morphological form, segmental - 42% and focal - 34% lesions were most often registered, polysegmental were 17%, and equity - 1%. The results of X- ray examination of patients allowed to confirm the diagnosis of community - acquired pneumonia in most patients. Conclusion. The most common clinical and morphological form of pneumonia in children remains focal and segmental forms with a high prevalence of right - sided pneumonia.
57-62 333
Aim - presents data on the number of cells of the lymphoid series and the cellular composition of the lymphoid tissue in the mucosa of the vaginal vestibule at different age periods of ontogenesis. Materials and methods. The study material was preparations of the vaginal vestibule taken from 45 women of different ages (from newborns to 75 years). By age periods, the material was subdivided according to the standard scheme of age periodization. Cross sections of the organ wall were stained with hematoxylin - eosin and according to Van Gieson. In a number of cases, the silvering of Grimelius was performed. Obtained during the study of digital data were subjected to statistical processing. Results. Analysis of the results showed that lymphoid formations are located mainly near the glands. Glandular - lymphoid relationships are less impressed in newborns, to the maximum extent from early childhood to the 1st period of adulthood, in the elderly and senile age of cells. There are fewer lymphoid rows near the initial divisions and in the stroma of the glands. The lymphoid apparatus of the vaginal vestibule is represented by all the morphogenetic forms of the lymphoid tissue. The qualitative composition of lymphoid tissue is of the same type in all its morphogenetic forms, regardless of age. It has been established that there are close microsynthopic connections between immune structures and small glands of the vestibule. The intensity of these relationships has ontogenetic features. They are relatively weak in new - borns, are maximal in early childhood and weaken after the 1st period of adulthood. Conclusion. The study allowed us to identify previously unknown patterns of morphogenesis of lymphoid structures of the vaginal vestibule.
63-68 398
Purpose. The study assess the effectiveness and safety of pulmonary veins atriums isolation (PVI) and radiofrequency ablation of the cavo - tricuspid isthmus with different modes of anticoagulation in patients with atrial fibrillation (AFb) and atrial flutter (AFl). Materials and methods. The study included 83 patients - 52 with AFb, 18 - with AFl and 13 - with both types of arrhythmia. Of all the included patients 12 used warfarin for antioagulation (15%), 17 - dabigataran (21%), 39 - rivaroxaban (46%) and 15 - apixaban (18%). For patients using warfarin a “bridge therapy” tactic was used. For patients using POAC the drug was cancelled at 2 half - life periods before the procedure. Intraoperational thromboembollic and haemorrhagic complications were calculated, arrhythmia relapses and delayed complications were controlled in 3 and 6 months after the procedure. Results. 18 arrhytmia relapses were reported during the study, among them 79% happened after PVI, 89% - after cavotricuspid isthmus, 62% - after treatment of both types of arrhythmia. 4 major haemorrhagic complications were reported during the study (intraoperational haemopericardium), 3 major thromboembolic complications (a stroke through 6 months after the procedure). The frequency of minor hemorrhagic events amounted to 8 cases. Both modes of anticoagulation are effective and safe for prevention of thromboembolic events in atrial fibrillation and flutter correction surgery, however, a large, although statistically insignificant number of minor haemorrhagic events occurred in the early post - procedure period with dabigataran. The results of the study show the effectiveness of arrhythmia surgery to be 79% in patients with AFb and 89% in patients with AFl.

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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)