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Metastasis of clear cell adenocarcinoma of the uterine corpus to the cerebellum

https://doi.org/10.47093/2218-7332.2020.11.4.43-49

Abstract

Brain metastases from clear cell uterine carcinoma are extremely rare and are associated with a poor prognosis.

Case report. A case of metastasis to the cerebellum in a 55-year-old patient with uterine adenocarcinoma is presented. The diagnosis of uterine cancer T2N1M1, stage IV was established in 2016. Extirpation of the uterus, lymph node dissection, radiation and chemotherapy were performed. In 2018, the patient developed neurological symptoms. On MRI scan a tumor in the posterior cranial fossa was found. Without progression in other organs and the area of the primary focus. The tumor was resected. Histology: brain metastasis from clear cell uterine adenocarcinoma. Radiation and chemotherapy were performed. The patient’s neurological symptoms regressed. In the future, a complete response to the treatment was recorded.

Discussion. Our case illustrates a rare metastasis from clear cell uterine adenocarcinoma. Brain metastases from uterine adenocarcinoma do not have a specific radiographic feature. Management of such patients should include a combined treatment, which can increase life expectancy. The life expectancy of our patient at the time of the control examination was 29 months.

About the Authors

N. V. Sevyan
Sechenov First Moscow State Medical University (Sechenov University); Blokhin National Medical Research Center of Oncology
Russian Federation

Nadezhda V. Sevyan, Cand. of Sci. (Medicine), Аssociate Professor, Department of Oncology

8/2, Trubetskaya str., Moscow, 119991

23, Kashirskoe highway, Moscow, 115478



Yu. A. Tsybulskaya
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Yulia A. Tsybulskaya, Cand. of Sci. (Medicine), Assistant Professor, Department of Radiation Diagnostics

8/2, Trubetskaya str., Moscow, 119991



V. B. Karakhan
Blokhin National Medical Research Center of Oncology
Russian Federation

Vladislav B. Karakhan, Dr. of Sci. (Medicine), Professor, Leading Researcher, Department of Neurosurgery

23, Kashirskoe highway, Moscow, 115478



A. Kh. Bekyashev
Blokhin National Medical Research Center of Oncology
Russian Federation

Ali Kh. Bekyashev, Dr. of Sci. (Medicine), Professor, a Head of Neurosurgery Department

23, Kashirskoe highway, Moscow, 115478



E. V. Prozorenko
Sechenov First Moscow State Medical University (Sechenov University); Blokhin National Medical Research Center of Oncology
Russian Federation

Evgeniy V. Prozorenko, Cand. of Sci. (Medicine), Assistant Professor, Department of Oncology

8/2, Trubetskaya str., Moscow, 119991

23, Kashirskoe highway, Moscow, 115478



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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)