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Elimination of hypoxia in acute autoimmune intravascular hemolysis with perfluorocarbon blood substituting emulsion in experiment

Abstract

Autoimmune intravascular hemolysis is an acute process of destruction of erythrocytes in the bloodstream, as a result of the action of antibodies and complement on the erythrocyte membrane. Toxins, as well as the products released by hemoparasites, can cause damage to the erythrocyte membrane, followed by activation of autoimmune reactions and manifestation of acute autoimmune intravascular hemolysis. The use of blood-substituting emulsion of perfluoroorganic compounds in anemia caused by acute autoimmune intravascular hemolysis is especially relevant in presence of contraindications to the use of donor erythrocytes. The use of artificial oxygen carriers makes it possible to provide organs and tissues with oxygen without inducing aggravation of the autoimmune process.

About the Authors

S. I. Votrin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


S. B. Bolevich
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


S. I. Vorobiev
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


A. S. Orlova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


S. S. Bolevich
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


B. I. Tachieva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


D. Yu. Korsakov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)