Sechenov Medical Journal

Advanced search

Mathematical modeling of macrophage reprogramming during inflammation and immunity processes: obstacles and opportunities

Full Text:


This mini-review is devoted to the problem of mathematical modeling of macrophage-related processes during inflammation and immunopatohological states, especially regarding the aspect of the modeling of gene expression modulatory mechanisms and macrophage reprogramming.

About the Authors

V. N. Sakharov
I.M. Sechenov First MSMU
Russian Federation


P. F. Litvitsky
I.M. Sechenov First MSMU
Russian Federation

Petr Frantsevich Litvitsky, head of the chair of pathophysiology

8/2 Trubetskaya str., Moscow, 119991

8 (985) 769–07–38


1. Hashimoto D., Chow A., Noizat C. et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes // Immunity. 2013. Vol. 38. № 4. P. 792–804 URL: (дата обращения: 11.10.2014);

2. Sica A., Mantovani A. Macrophage plasticity and polarization: in vivo veritas // J. Clin. Invest. 2012. Vol. 122. № 3. P. 787-95. URL: (дата обращения: 26.11.2014);

3. Smith A.M., McCullers J.A., Adler F.R. Mathematical model of a three-stage innate immune response to a pneumococcal lung infection // J. Theor. Biol. 2011. Vol. 276 № 1. P. 106-116 URL: (дата обращения: 02.10.2014);

4. Su B., Zhou W., Dorman K. S., Jones D. E. Mathematical Modelling of Immune Response in Tissues // Computational and Mathematical Methods in Medicine Vol. 10. № 1. P. 9-38 URL: (дата обращения: 16.11.2014);

5. Zhou W. Mathematical modeling of MHC class II mediated immune responses in tissues (2010). Graduate Theses and Dissertations. Paper 11440. URL: (дата обращения: 02.10.2014);

6. Wang Y., Yang T., Ma Y. Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction // BMC Genomics. 2012. № 13 (Suppl 6):S21. 8 p. URL: (дата обращения: 11.10.2014);

7. Nedosekina E.A., Ananko E.A., Likhoshvai V.A. Cоnstruction of mathematical model of the gene network on macrophage activation under the action of IFN-γ and LPS // Bioinformatics of Genom Regulation and Structure. 2002. P. 156-159 URL: (дата обращения: 02.10.2014).


Views: 22

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)