Mathematical modeling of macrophage reprogramming during inflammation and immunity processes: obstacles and opportunities
Abstract
This mini-review is devoted to the problem of mathematical modeling of macrophage-related processes during inflammation and immunopatohological states, especially regarding the aspect of the modeling of gene expression modulatory mechanisms and macrophage reprogramming.
About the Authors
V. N. SakharovRussian Federation
post-graduate
P. F. Litvitsky
Russian Federation
Petr Frantsevich Litvitsky, head of the chair of pathophysiology
8/2 Trubetskaya str., Moscow, 119991
8 (985) 769–07–38
References
1. Hashimoto D., Chow A., Noizat C. et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes // Immunity. 2013. Vol. 38. № 4. P. 792–804 URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853406 (дата обращения: 11.10.2014);
2. Sica A., Mantovani A. Macrophage plasticity and polarization: in vivo veritas // J. Clin. Invest. 2012. Vol. 122. № 3. P. 787-95. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287223/ (дата обращения: 26.11.2014);
3. Smith A.M., McCullers J.A., Adler F.R. Mathematical model of a three-stage innate immune response to a pneumococcal lung infection // J. Theor. Biol. 2011. Vol. 276 № 1. P. 106-116 URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066295/pdf/nihms-271793.pdf (дата обращения: 02.10.2014);
4. Su B., Zhou W., Dorman K. S., Jones D. E. Mathematical Modelling of Immune Response in Tissues // Computational and Mathematical Methods in Medicine Vol. 10. № 1. P. 9-38 URL: http://downloads.hindawi.com/journals/cmmm/2009/537013.pdf (дата обращения: 16.11.2014);
5. Zhou W. Mathematical modeling of MHC class II mediated immune responses in tissues (2010). Graduate Theses and Dissertations. Paper 11440. URL: http://www.lib.dr.iastate.edu/etd/11440 (дата обращения: 02.10.2014);
6. Wang Y., Yang T., Ma Y. Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction // BMC Genomics. 2012. № 13 (Suppl 6):S21. 8 p. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481436/ (дата обращения: 11.10.2014);
7. Nedosekina E.A., Ananko E.A., Likhoshvai V.A. Cоnstruction of mathematical model of the gene network on macrophage activation under the action of IFN-γ and LPS // Bioinformatics of Genom Regulation and Structure. 2002. P. 156-159 URL: http://www.bionet.nsc.ru/meeting/bgrs_proceedings/papers/2002/BGRS_2002_2_046.pdf (дата обращения: 02.10.2014).