Epithelial reticular cells of the thymus and the regulatory T-lymphocytes
摘要
The article presents a review of the literature. The article presents the published data on the role of reticular epithelial cells in the formation of specific microenvironment in the cortex and medulla of thymic lobules. Thymic microenvironment plays a key role in T-cell differentiation. Discusses the role of medullar epithelial cells in the development of regulatory T-lymphocytes and induction of tolerance.
参考
1. Жулай Г.А., Олейник Е.К. Регуляторные Т-лимфоциты CD4+CD25+FOXP3+. Перспективы применения в иммунотерапии // Труды Карельского научного центра РАН. 2012. №2. С.3-17.
2. Sakaguchi S., .Sakaguchi N., Asano M. Immunologic self-tolerance by activated Tcells expressing IL-2 receptor α-chains(CD25).Breakdown of a singl mechanism of self–tolerans causes various autoimmune diseases // J. Immunol. 1995. Vol. 155. P. 1151-1164.
3. Yang Z. Z. Ansell S. M. The role of Treg cells in the cancer immunological response // Am. J. Immunol. 2009. Vol. 5–1. P 17-28.
4. Shevach E. M. Mechanisms of Foxp3+ T-regulatory cellmediated suppression // Immuniti. 2009. Vol 30. Р. 636-645.
5. Ross M.H. Histology: a text and atlas /M.H. Ross, G.I. Kaye, P. Wojciech. Baltimor, Lippincott Williams, Wilkins. 2003. 875 p.
6. Ileana P., Zubcova I., Medvedovic M. Regeneration of the adult thymus is preceded by the expansion of K5+K8 epithelial cell progenitors and by increased expression of Trp 63, cMyc and Tcf3 transcription factors in the thymic stroma // International Immunology. 2008. Vol. 19, Ilssue 11. P. 1249-1260.
7. Eun N.L., Kyeong P.J., Lee J. Characterization of the expression of cytokeratins 5, 8 and 14in mouse thymic epithelial cells during thymus regeneration following acute thymic involution // Anatomy and Cell Biology. 2011. Vol. 44(1). P.14-24.
8. Anderson G., Takahama Y. Thymic epithelial cells: working class heroes for Tcell development and repertoire selection // Trends Immunol. 2012. №33. Р. 256-263.
9. Singh J. The ultrastructure of epithelial reticular cells // The thymus gland. 1981. Р. 133-150.
10. Nabarra B., Andrianarison J. Ultrastructural study of thymic reticulum 1. Epithelial component // Thymus. 1987. V.1. №2. P.95-121.
11. Ярилин А.А., Шарова Н.И., Дзуцев А.Х. Взаимодействие T-лимфоцитов и эпителиальных клеток в тимусе // Russian J. Immunol. 1999. №4. Р. 15-20.
12. Yarilin A.A., Sharova N.I., Bulanova E. C., Kotchergina N.I., Mitin A.A. Hormone production by epithelial cells of human thymus in vitro // Russian J. Immunol. 1996. 1. Р. 18-22.
13. Wekerle H., Ketelson U.P. Thymic nurse cells – Ia bearing epithelium involved in T–lymphocyte differentiation // Nature. 1980. 283. Р.402-404.
14. Pezzano M., Samms M., Martines M., Guyden J. Questionable Thymic Nurse Cells // Microbiology and molecular biology reviews. 2001, V.65. № 3. Р. 390-403.
15. Ezaki T., Matsuno K., Kotani M. Thymic nurse cells (TNC) in spontaneous thymoma BUF/Mna rats as a model to study their role in T-cell development // Immunology. 1991. V. 73. Р. 151-158.
16. Geenen Y., Defresne M., Robert F., et al. The neurohormonal thymic microenvironment: immunocytochemical evidence that thymic nurse cells are neuroendocrine cells // Neuroendocrinology. 1988. V. 47. Р. 365-368.
17. Торбек В.Э. Морфогенез тимуса. М. Изд-во РУДН. 1995. 114 с.
18. Торбек В.Э., Юрина Н.А. Ультраструктура эпителиоцитов тимуса потомства при изменении гормонального фона в функциональной системе мать-плод // Вестник Российского Университета дружбы народов. Сер. «Медицина». 2000. № 2. С. 45-49.
19. Беловешкин А.Г. Ультраструктура кератинового ядра телец Гассаля тимуса человека // Сборник научных работ «Труды молодых ученых» БГМУ. 2011. С. 9-13.
20. Anderson G, Song Baik, Cowan J., Holland A., McCarthy N., Kyoko Nakamura et al. Mechanisms of Thymus Medulla. Development and Function. // Current Topics in Microbiology and Immunology. 2014. V. 373. P. 19–47. Published Online: 24 April 2013.
21. Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H. et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance // J. Exp. Med. 2008. V. 205. Р. 2827–2838.
22. Соquet J.M. Ribot J. C.,Babala N, Middendorp S.,van der Horst G., Xiao Y., Neves J.F., Fonseca-Pereira D., Pennigton D.J., Silva-Santos B., Borst J. Epithelial and dendritic cells in the the thymic medulla promote СD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway // J. Exp. Med. 2013. V. 210(4). Р. 715-728.
23. Донецкова А.Д., Шарова Н.И., Никонова М.Ф., Ярилин А.А. Индукция экспрессии транскрипционного фактора FOXP3 в кроветворных клетках-предшественниках и тимоцитах человека in vitro // Иммунология. 2010. № 5. С. 232.
24. Gordon J., Wilson V. A., Blair N.F., Sheridan J. et al. Functional evidens for a singl endodermal origin for the thymic epithelium // Nat. Immunol. 2004. 5. Р. 546-553.
25. Nehls M., Kyewski B., Messerle M. et al. Two genetically separable steps in the differentiation of thymic epithelium // Science. 1996. V. 272. Р. 886-889.
26. Ohigashi I., Zuklys S., Sakata M., Mayer C.E. et al. Aireexpressing thymic medullary epithelial cells originate from β5t-express progenitor cells // Published on line May 29, 2013.
27. Alves N., Takahama Y., Ohigashi I., Ribeiro A. et al. Serial progression of cortical and medullary thymic epithelial microenvironments // Europ. Journal of Immunology. 2014. v. 44. Р. 16-22. Article first published on line 4 dec. 2013.