Sechenov Medical Journal

Advanced search

An experience of radiofrequency ablation in the treatment of renal cell carcinoma

Full Text:


Radiofrequency ablation is a minimally invasive treatment for local destruction, widely used in the combined treatment of kidney cancer. Application of radiofrequency ablation allowed to expand the indications for more radical treatment of kidney tumors in patients who may not perform traditional nephrectomy or partial nephrectomy due to extremely burdened somatic status. Efficacy and safety of RFA greatly increased when it is combined with presuperselective occlusion of blood vessels that feed the tumor. We have experience in the use of superselective embolization in combination with RFA when a kidney tumor is in two patients. In both observations obtained good results of combined treatment. In some patients, this combination (CCE + RFA) may be an alternative to open surgery, thus expanding the range of modern minimally invasive treatments for kidney tumors.

About the Authors

P. V. Glybochko
I.M. Sechenov First MSMU
Russian Federation

MD, corresp. member of RAMS, prof., rector

Yu. G. Alyaev
I.M. Sechenov First MSMU
Russian Federation

Yury Gennadievich Alyaev, MD, corresp. member of RAMS, prof., honored scientist of RF, director of the Research centre of uronephrology and reproductive health, head of the chair of urology

2–1 B. Pirogovskaya str., Moscow, 119435

8 (499) 248–71–00

S. A. Kondrashin
I.M. Sechenov First MSMU
Russian Federation

MD, prof. of the chair of beam diagnostics and radiotherapy

N. I. Sorokin
I.M. Sechenov First MSMU
Russian Federation

PhD, head of the urology department of the University Hospital № 2

E. V. Shpot’
I.M. Sechenov First MSMU
Russian Federation

PhD, associate prof. of the chair of urology

G. A. Martirosyan
I.M. Sechenov First MSMU
Russian Federation

urologist of the University Hospital № 2


1. Malignancies in Russia in 2008 (morbidity and mortality) / Ed. by V.I. Chissov, V.V. Starinsky, G.V. Petrova. M. FSU «MSROI named after P.A. Herzen Rosmedtechnology». 2010.

2. Pavlov A.Yu., Klimemko A.A., Momdzhan B.K., Ivanov S.A. Radiofrequency interstitial thermoablation (RFA) of renal cancer // Eksperimental’naya i klinicheskaya urologiya. 2011; 2–3: 112–113.

3. European Network of Cancer Registries. Eurocim version 4.0. European incidence database V2.3, 730 entity dictionary (2001), Lyon, 2001.

4. Chow W.H., Devesa S.S., Warren J.L., Freumeni J.F.Jr. Rising incidence of renal cell carcer in the United States // JAMA 1999; 281: 1628-31.

5. Nguyen M.M., ill I.S., Ellison L.M. The evolving presentation of renal carcinoma in the United States: trends from the Surveillance, Epidemiology, and End Results program // J. Urol. 2006; 176: 2397-400; discussion 2400.

6. Kummerlin I.P., ten Kate F.J., Wij kstra H., de la Rosette J.J., Laguna M.P. Changes in the stage and surgical management of renal tumours during 1995-2005: an analysis of the Dutch national histopathology registry // BJU Int. 2008 Sep; 102(8): 946-51. Epub 2008 Jun 28.

7. Ankem M.K., Nakada S.Y. Needle-nephron-sparing surgery // BJU Int. 2005; 95 (Suppl 2): 46-51.

8. Havranek E., Anderson C. Future prospects for nephron conservation in renal cell carcinoma. In: Kirby R.S., O’Leary M.P., editors. Hot topics in urology. Amsterdam, The Netherlands: Elsevier, 2004; pp. 227-38.

9. Marberger M., Mauerman J. Energy ablation nephronsparing treatment of renal tumors // AUA Update Series 2004; 23: 178-83.

10. Reddan D.N., Raj G.V., Polascik T.J. Management of small renal tumors: an overview // Am. J. Med. 2001; 110: 558-62.

11. Weld K.J., Landman L. Comparison of cryoablation, radiofrequency ablation and high-intensity focused ultrasound for treating small renal tumors // BJU Int. 2005; 96: 1224-9.

12. Uzzo R.G., Novick A.C. Nephron sparing surgery for renal tumors: indications techniques and outcomes // J. Urol. 166: 6–18.

13. Dolgushin B.I., Kosyrev V.Yu., Ramprabanant S. Radiofrequency ablation in oncology // Prakticheskaya onkologiya. 2007; 8 (4): 219–227.

14. Vogl T.J., Helmberger T.K., Mack M.G., Reiser M.F. (Eds.) Percutaneous Tumor Ablation in Medical Radiology. ISBN 978-3-540-22518-8 Springer. Berlin, Heidelberg, New York, 2008)

15. Hal W.H., McGahan J.P., Link D.P., deVere White R.W. Combined Embolization and Percutaneous Radiofrequency Ablation of a Solid Renal Tumor // AJR 2000; 174: 1592-1594.

16. Yamakado K., Nakatsuka A., Kobayashi S., Akeboshi M., Takaki H., Kariya Z., Kinbara H., Arima K., Yanagawa M., Hori Y., Kato H., Sugimura Y., Takeda K. //Radiofrequency ablation combined with renal arterial embolization for the treatment of unresectable renal cell carcinoma larger than 3.5 cm: initial experience // Cardiovasc Intervent Radiol. 2006 May-Jun; 29(3): 389-94.

17. Klingler H.C., Marberger M., Mauermann J. et al. ’Skipping’ is still a problem with radiofrequency ablation of small renal tumours // BJU Int. 2007; 99: 998–1001.

18. Goldberg S.N., Gazelle G.S., Mueller P.R. Thermal ablation therapy for focal malignancy: A unifi ed approach to underlying principles, techniques and diagnostic imaging guidance // Am. J. Roentgenol. 2000; 174: 323-31.

19. Lee M. Ellis, Steven A. Curley, Kenneth K. Tanabe. Radiofrequency Ablation for Cancer.Current Indications, Techniques, and Outcomes. 2004 Springer-Verlag. New York, Inc.

20. Salagierski M., Salagierski M. Radiofrequency ablation partial nephrectomy: a new method of nephron-sparing surgery in selected patients // Int. J. Urol. 2006 Nov; 13(11): 1456-9.

21. Veltri A., Garetto I., Pagano E., Tosetti I., Sacchetto P., Fava C. Percutaneous RF termal ablation of renal tumors: is US guidance really less favorable than other imaging guidance techniques? // Cardiovasc Intervent Radiol. 2009 Jan; 32(1): 76-85. Epub 2008 Aug 15.

22. Schirmang T.C., Mayo-Smith W.W., Dupuy D.E., Beland M.D., Grand D.J. Kidney neoplasms: renal halo sign after percutaneous radiofrequency ablation-incidence and clinical importance in 101 consecutive patients // Radiology. 2009 Oct; 253(1): 263-9. Epub 2009 Jul 31.

23. Varkarakis I.M., Allaf M.E., Inagaki T., Bhayani S.B., Chan D.Y., Su L.M., Jarrett T.W., Kavoussi L.R., Solomon S.B. Percutaneous radio frequency ablation of renal masses: results at a 2-year mean followup // J. Urol. 2005 Aug; 174(2): 456-60; discussion 460.

24. Gervais D.A., McGovern F.J., Arellano R.S., McDougal W.S., Mueller P.R. Radiofrequency ablation of renal cell carcinoma: part1, indications, results, and role in patient management over a 6-year period and ablation of 100 tumors // AJR Am J Roentgenol. 2005 Jul; 185(1): 64-71.

25. Zagoria R.J., Traver M.A., Werle D.M., Perini M., Hayasaka S., Clark P.E., Oncologic Effi cacy of CT-Guided Percutaneous Radiofrequency Ablation of Renal Cell Carcinomas // Interventional Radiology. AJR: 189, August 2007.

26. Stern J.M., Gupta A., Raman J.D., Cost N., Lucas S., Lotan Y., Raj G.V., Cadeddu J.A. Radiofrequency ablation of small renal cortical tumours in healthy adults: renal function preservation and intermediate oncological outcome // BJU Int. 2009, 104, 786-789.

27. Carey R.I., Leveillee R.J. First prize: direct real-time temperature monitoring for laporoscopic and CT-guided radiofrequency ablation of renal tumors between 3 and 5 cm // J. Endourol. 2007 Aug; 21(8): 807-13.

28. Messerli F.H., Grossman E. Management of small renal tumors: an overview // Am J Med 2001; 110: 558–562.

29. Joniau S., Tailly T., Goeman L., Blyweert W., Gontero P., Joyce A. Kidney radiofrequency ablation for small renal tumors: oncologic effi cacy // J Endourol. 2010 May; 24(5): 721-8.

30. Hegarty N.J., Gill I.S., Desai M.M., Remer E.M., O'Malley C.M., Kaouk J.H. Probe-ablative nephronsparing surgery: cryoablation versus radiofrequency ablation // Urology. 2006 Jul; 68(1 Suppl): 7-13.

31. Breen D.J., Rutherford E.E., Stedman B., Roy-Choudhury S.H., Cast J.E., Hayes M.C., Smart C.J. Management of renal tumors by image-guided radiofrequency ablation: experience in 105 tumors // Cardiovasc Intervent Radiol. 2007 Sep-Oct; 30(5): 936-42. Epub 2007 Jun 18.

32. Farrell M.A., Di Marco D.C. Imaging-guided radiofrequency ablation of solid renal tumors // AJR Amer. J. Roentgenol. 2003. Vol. 180. P. 1509.

33. Gervais D.A., Arellano R.S., McGovern F.J. et al. Radiofrequency ablation of renal cell carcinoma: part 2. Lessons learnedwith ablation of 100 tumors // AJR Amer. J. Roentgenol. 2005. Vol.185. P.72-80.

34. Mahnken A.H., Gunther R.W., Tacke J. Radiofrequency ablation of renal Tumors // Europ. Radiol. 2004. Vol. 14(8). P.1449-1455.

35. Mahnken A.H., Rohde D., Brkovic D. et al. Percutaneous radiofrequency ablation of renal cell carcinoma: preliminary results // Acta Radiol. 2005. Vol. 46(2). P. 208- 214.

36. Mayo-Smith W.W., Dupuy D.E., Parikh P.M. et al. Imaging-guided percutaneous radiofrequency ablation of solid renal masses: techniques and outcomes of 38 treatment sessions in 32 consecutive patients // AJR Amer. J. Roentgenol. 2003. Vol. 180 (6). P.1503-1508.

37. Pavlovich C.P., Walther M.M., Choyke P.L. et al. Percutaneous radio frequency ablation of small renal tumors: initial results // J. Urol. 2002. Vol.167. P.10-15.

38. Mondshine R.T., Owens S., Mondschein J.I., Cizman B., Stavropoulos S.W., Clark T.W. Combination embolization and radiofrequency ablation therapy for renal cell carcinoma in the setting of coexisting arterial disease // J. Vasc. Interv. Radiol. 2008 Apr; 19(4): 616-20.

39. Gebauer B., Werk M., Lopez-Hänninen E., Felix R., Althaus P. Radiofrequency ablation in combination with embolization in metachronous recurrent renal cancer in solitary kidney after contralateral tumor nephrectomy // Cardiovasc Interv. Radiol. 2007 Jul-Aug; 30(4): 644-9.

40. Arima K., Yamakado K., Kinbara H., Nakatsuka A., Takeda K., Sugimura Y. Percutaneous radiofrequency ablation with transarterial embolization is useful for treatment of stage 1 renal cell carcinoma with surgical risk: results at 2-year mean follow up // Int. J. Urol. 2007 Jul; 14(7): 585- 90; discussion 590.

41. Nakasone Y., Kawanaka K., Ikeda O., Tamura Y., Yamashita Y. Sequential combination treatment (arterial embolization and percutaneous radiofrequency ablation) of inoperable renal cell carcinoma: single-center pilot study // Acta Radiol. 2012 May 1; 53(4): 410-4. Epub 2012 Mar 5.


Views: 29

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)