Modern technologies in early detection and differential diagnostics of gastric cancer
Abstract
The article deals with the estimation of sensitivity of different diagnostic methods in differential diagnostics of stomach diseases. We found that the performance of the fluorescent diagnostics is very high in the primary diagnosis of gastric cancer and in the differential diagnosis of benign and malignant stomach lesions: sensitivity — 96%, specificity — 78%. The detection rate of gastric cancer with the use of transabdominal ultrasonography reaches 95,6% for the localization of the tumor in antrum or lower third of the stomach body. The diagnostic accuracy is higher in cases of advanced gastric cancer. We also estimate the diagnostic performance of the multidetector computed tomography in the detection and staging of gastric cancer. Multidetector computed tomography with multiplanar reformation and virtual gastroscopy offers new opportunities for imaging of gastric diseases. The detection rate of gastric cancer using this method is 97% regardless of the localization of the tumor. Diagnostic potential of all mentioned methods of visualization of gastric lesions needs to be further explored.
About the Authors
A. F. ChernousovRussian Federation
MD, prof., member of RAMS, honoured scientist of Russia, head of the chair of faculty surgery № 1
V. V. Levkin
Russian Federation
PhD, associate prof. of the chair of faculty surgery № 1
A. V. Egorov
Russian Federation
MD, prof. of the chair of faculty surgery № 1, head of the Surgical oncology department of the Clinic of faculty
surgery
S. S. Kharnas
Russian Federation
MD, prof. of the chair of faculty surgery № 1
T. V. Khorobrykh
Russian Federation
MD, prof. of the chair of faculty surgery № 1
N. V. Gagarina
Russian Federation
PhD, physician of the Radiology department of the University hospital № 1
N. S. Gorovaya
Russian Federation
PhD, head of the department of functional diagnostics
V. Ya. Zavodnov
Russian Federation
PhD, head of the Endoscopy department
V. B. Loshchenov
Russian Federation
Doctor of technical sciences, prof., head of the Laboratory
N. L. Okhotnikova
Russian Federation
PhD, endoscopist of the Endoscopy department
E. Yu. Patoka
Russian Federation
PhD, researcher
S. K. Ternovoy
Russian Federation
MD, academician of RAMS, prof., head of the chair of radiology
E. V. Fominykh
Russian Federation
PhD, head of the Radiology department of the University hospital № 1
O. V. Ogneva
Russian Federation
post-graduate student of the chair of faculty surgery № 1
References
1. Давыдов М.И., Аксель Е.М. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2004 г. // Вестник РОНЦ им. Н.Н. Блохина РАМН. — 2006. — Т. 17. — № 3. — С. 45–46.
2. Давыдов М.И., Аксель Е.М. Смертность населения России и стран СНГ от злокачественных новообразований в 2004 г. // Вестник РОНЦ им. Н.Н. Блохина РАМН. — 2006. — Т. 17. — № 3. — С. 78.
3. Портной Л.М. Современная лучевая диагностика в гастроэнтерологии и гастроэнтероонкологии. — М.: Видар-М, 2003. — 218 с.
4. Полсачев В.И. Дооперационная флюоресцентная диагностика распространенности рака желудка // Вестник хирургии. — 1989. — № 12. — С. 17–19.
5. Полсачев В.И. Флюоресцентный метод в дифференциальной диагностике доброкачественных и злокачественных заболеваний желудка // Вестник хирургии. — 1992. — № 1. — С. 95–97.
6. Горовая Н.С. Роль комплексного ультразвукового исследования в хирургическом лечении больных раком желудка. Автореф. … канд. мед. наук. — М., 2009.
7. Федоров В.Д., Карамазовский Г.Г., Гузеева Е.Б. и др. Виртуальное хирургическое моделирование на основе данных компьютерной томографии. — М.: Видар-М, 2003. — 184 с.
8. Kim J.H., Eun H.W., Choi J.H. et al. Diagnostic performance of virtual gastroscopy using MDCT in early gastric cancer compared with 2D axial CT: focusing on interobserver variation // Am. J. Roentgenol. — 2007. — Vol. 189. — P. 299–305.
9. Chen F., Ni Y.C., Zheng K.E. et al. Spiral CT in gastric carcinoma: comparison with barium study, fi beroptic gastroscopy and histopathology // World J. Gastroenterol. — 2003. — Vol. 9(7). — P. 1404–1408.
10. Kim J.H., Eun H.W., Hong S.S. et al. Early gastric cancer: virtual gastroscopy // Abdom. Imaging. — 2006. — Vol. 31(5). — P. 507–513.
11. Cidon E., Cuenca I. Gastric adenocarcinoma: is computed tomography useful in preoperative staging? // Clin. Med.: Oncology. — 2009. — Vol. 3. — P. 91–97.
12. Chen C.Y., Wu D.C., Kuo Y.T. et al. MDCT for diff erentiation of category T1 and T2 malignant lesions from benign gastric ulcers // Am. J. Roentgenol. — 2008. — Vol. 190(6). — P. 1505–1511.