Opportunities for management of macrophage phenotype reprogramming
Abstract
This article reviews the recent literature on opportunities for reprogramming of macrophage phenotypes. Much attention is devoted to the stimulus, signal pathways and its effects as well as some regulational mechanisms.
About the Authors
V. N. Sakharov
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
post-graduate
P. F. Litvitsky
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
Petr Frantsevich Litvitsky, MD, corresp. member of RAS, prof., head of the chair of pathophysiology
8/2 Trubetskaya str., Moscow, 119991
8 (985) 769–07–38
References
1. Martinez F.O., Gordon. S. The M1 and M2 paradigm of macrophage activation: time for reassessment // F1000Prime Reports. 2014. Vol. 6. № 13. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944738/ (дата обращения: 05.04.2014).
2. Edwards J.P., Zhang X., Frauwirth K.A., Mosser D.M. Biochemical and functional characterization of three activated macrophage populations // J. Leukoc. Biol. 2006. Vol. 80. № 6. P. 1298–1307. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642590/ (дата обращения: 15.04.2014).
3. Lyamina S.V., Vedenikin T.Yu., Kruglov S.V. et al. Characteristics of phagocytic and migration activity of alveolar macrophages of M1 and M2 phenotypes // Fundamentalnye issledovaniya. 2011; 11(3): 536–539. URL: http://www.rae.ru/fs/?section=content&op=show_article&article_id=7981832 (date accessed: 15.04.2014).
4. Zhu M., John S., Berg M., Leonard W.J. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling // Cell. 1999. № 96(1). P. 121-130. URL: http://www.ncbi.nlm.nih.gov/pubmed/9989503 (дата обращения: 22.08.2014).
5. Whyte C.S., Bishop E.T., Ruckerl D. et al. Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function // J. Leukoc. Biol. 2011. № 90. P. 845–854. URL: http://m.jleukbio.org/content/90/5/845.full.pdf+html (дата обращения: 17.04.2014).
6. Van Dyken S.J., Locksley R.M. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease // Ann. Rev. Immunol. 2013. № 31. P. 317–343. http://http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606684/ (дата обращения: 15.04.2014).
7. Verstak B., Nagpal K., Bottomley S.P. et al. MyD88 adapterlike (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinfl ammatory responses // J. Biol. Chem. 2009. № 284(36). P. 24192–24203. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782013/ (дата обращения: 22.08.2014).
8. Reim D., Rossmann-Bloeck T., Jusek G. et al. Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response // J. Leukoc. Biol. 2011. № 90. P. 613–620 URL: http://www.jleukbio.org/content/90/3/613.full (дата обращения: 17.04.2014).
9. Li S.N., Wang W., Fu S.P. et al. IL-21 modulates release of proinfl ammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways // Mediators of Infl ammation. Vol. 2013. Article ID 548073. 12 p. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888770/ (дата обращения:16.04.2014).
10. Xu H., Zhu J., Smith S. et al. Notch-RBP-J signaling regulates IRF8 to promote infl ammatory macrophage polarization // Nat. Immunol. 2012. Vol. 13. № 7. P. 642–650. URL: http://www.ncbi.nlm.nih.gov/pubmed/22610140 (дата обращения: 02.05.2014).
11. Shi Y., Liu C.H., Roberts A.I. et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know // Cell Res. 2006. 16(2). P. 126–133. URL: http://www.nature.com/cr/journal/v16/n2/full/7310017a.html (дата обращения: 22.08.2014).
12. Iyer S.S., Cheng G. Role of interleukin 10 transcriptional regulation in infl ammation and autoimmune disease // Crit. Rev. Immunol. 2012. № 32(1). P. 23–63. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/ (дата обращения: 23.08.2014).
13. Arnold C.E., Whyte C.S., Gordon P. et al. A critical role for suppressor of cytokine signaling 3 in promoting M1 macrophage activation and function in vitro and in vivo //Immunology. 2013. № 141. P. 96–110. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893853/ (дата обращения: 09.04.2014).
14. McCall C.E., El Gazzar M., Liu T. et al. Epigenetics, bioenergetics, and microRNA coordinate gene-specifi c reprogramming during acute systemic infl ammation // J. Leukoc. Biol. 2011. № 90. P. 439–446. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157901 (дата обращения: 17.04.2014).
15. Chen C.H., Wang C.Z., Wang Y.H. et al. Eff ects of lowlevel laser therapy on M1-related cytokine expression in monocytes via histone modifi cation // Mediators of Infl ammation. Vol. 2014. Article ID 625048. 13 p. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945284/ (дата обращения: 15.04.2014).
Review
Views:
250
Email this article 