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Features of the manifestation and course of Crohn’s disease in three brothers

https://doi.org/10.47093/2218-7332.2020.11.3.70-77

Abstract

Hereditary predisposition is the most significant risk factor for Crohn’s disease (CD) in siblings.
Case reports. CD was diagnosed in 3 brothers in a family with 6 children of the same generation: the disease manifested itself in one — at the age of 15 years and in two brothers — at the age of 17 years. In the older brother, CD manifested with acute intestinal obstruction, ileum perforation, diffuse peritonitis; in the middle — with symptoms similar to appendicular infiltrate. Both brothers underwent resection of the terminal ileum, cecum, and part of the ascending colon with the imposition of ileoascendoanastomosis. The younger brother was diagnosed with a non-stricturing, non-penetrating form of CD with a gradual onset and no complications. Among the siblings without CD, two have rheumatoid arthritis and vitiligo.
Discussion. Similar signs of the familial form of CD were young age of manifestation and ileocolonic disease location; distinctive signs — the presence of complications and surgical interventions in only two brothers. A special feature of the case reports is the CD development only in boys and the combination of three different autoimmune diseases in one generation of the family.

About the Authors

A. V. Morkovina
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anna V. Morkovina, clinical resident, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology

8/2, Trubetskaya str., Moscow, 119991

+7 (961) 1427449



E. Yu. Yuryeva
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena Yu. Yuryeva, Head of the Department of Gastroenterology, Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology, University Clinical Hospital No. 2 

8/2, Trubetskaya str., Moscow, 119991



T. L. Lapina
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Tatiana L. Lapina, Cand. оf Sci. (Medicine), Associate Professor, Department of Internal Diseases Propaedeutics, Gastroenterology and Hepatology

8/2, Trubetskaya str., Moscow, 119991



P. V. Pavlov
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Pavel V. Pavlov, Cand. оf Sci. (Medicine), Head of the Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2

8/2, Trubetskaya str., Moscow, 119991



A. S. Tertychnyy
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexander S. Tertychnyy, Dr. of Sci. (Medicine), Professor, Department of Pathological Anatomy named after academician A.I. Strukov

8/2, Trubetskaya str., Moscow, 119991



A. A. Sheptulin
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Arkadiy A. Sheptulin, Dr. of Sci. (Medicine), Professor, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology

8/2, Trubetskaya str., Moscow, 119991



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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)