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SYNERGY IN MIXED RIBAVERIN-INTERFERON AQUEOS SOLUTIONS

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Abstract

Spectrophotometric method of ribavirin determination in aqueous solutions was improved. Feasibility of ribavirin determination in the presence of protein was confirmed. Colloid-chemistry behavior of ribavirin, interferon and their mixture were investigated. We found that these substances are surface active. The synergistic effect was revealed in ribavirin-interferon mixture in aqueous phase. Particular aspects of ribavirin and interferon adsorption from aqueous phase were specified and characteristics of adsorption layers were determined. We found the influence of ribavervirin on isoelectric point and association parameters of interferon macromolecules.

About the Authors

K. Kienskaya
Mendeleev Russian University of Chemical Technology
Russian Federation


E. Ilyushenko
Mendeleev Russian University of Chemical Technology
Russian Federation


I. Belova
Mendeleev Russian University of Chemical Technology
Russian Federation


M. V. Sardushkin
Mendeleev Russian University of Chemical Technology
Russian Federation


N. Guznova
Polyclinic VIRMED
Russian Federation


V. Piskunova
Mendeleev Russian University of Chemical Technology
Russian Federation


A. Dremuk
Mendeleev Russian University of Chemical Technology
Russian Federation


R. Ibragimova
Mendeleev Russian University of Chemical Technology
Russian Federation


A. V. Kukharenko
Mendeleev Russian University of Chemical Technology
Russian Federation


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)