SYNERGY IN MIXED RIBAVERIN-INTERFERON AQUEOS SOLUTIONS
摘要
Spectrophotometric method of ribavirin determination in aqueous solutions was improved. Feasibility of ribavirin determination in the presence of protein was confirmed. Colloid-chemistry behavior of ribavirin, interferon and their mixture were investigated. We found that these substances are surface active. The synergistic effect was revealed in ribavirin-interferon mixture in aqueous phase. Particular aspects of ribavirin and interferon adsorption from aqueous phase were specified and characteristics of adsorption layers were determined. We found the influence of ribavervirin on isoelectric point and association parameters of interferon macromolecules.
关于作者
K. Kienskaya
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
E. Ilyushenko
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
I. Belova
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
M. Sardushkin
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
N. Guznova
Polyclinic VIRMED
俄罗斯联邦
俄罗斯联邦
V. Piskunova
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
A. Dremuk
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
R. Ibragimova
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
A. Kukharenko
Mendeleev Russian University of Chemical Technology
俄罗斯联邦
俄罗斯联邦
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