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In the examined patients with rheumatoid arthritis (RA), the VEGF level in blood was 2 times higher than the control and 30 % higher in the high-positive patients with anti-CCP. VEGF correlated with clinical parameters of severe RA, high disease activity, effusion to the joint cavity and hypervascularization of the synovial lining. The concentration of FGF in the blood in RA patients was 2.5 times higher than control and 25 % higher in the high-positive patients with anti-CCP. FGF correlated with the duration of the disease, parameters of clinical course, the synovial thickening, the presence of pannus and osteochondral erosion. High levels of VEGF, FGF in the blood can be used as markers of severe destruction diseases in RA patients

About the Author

E. B. Komarova
State Institution «Lugansk State Medical University» of the Lugansk Peopleʼs Republic
Russian Federation


1. Чичасова Н.В., Владимиров С.А., Иголкина Е.В., Имаметдинова Г.Р. Бремя ревматоидного артрита: медицинские и социальные проблемы. Научно-практическая ревматология. 2009; 47(1): 4-10.

2. Зинчук И.Ю., Амирджанова В.Н. Социальное бремя ревматоидного артрита. Научно-практическая ревматология. 2014; 52(3): 331-335.

3. Valesini G., Alessandri C. Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems. Arthritis. Res. Ther. 2009; 11: 125.

4. Авдеева А.С. Новиков А.А., Александрова Е.Н. и др. Связь уровней цитокинов с активностью заболевания, уровнем аутоантител и деструктивными изменениями суставов при раннем ревматоидном артрите. Научно-практическая ревматология. 2015; 53(4): 385-390.

5. Ten Cate D.F., Luime J.J., Swen N. et al. Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis - a systematic review of the literature. Arthritis Res. Ther. 2013; 15(1): R4.

6. Fukae J., Tanimura K., Atsumi T., Koike T. Sonographic synovial vascularity of synovitis in rheumatoid arthritis. Rheumatology (Oxford). 2014; 53(4): 586-91.

7. Taylor P.C. Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapy. Rheumat. 2005; 44(6): 721-728.

8. Dhaouadi T., Sfar I., Abelmoula L. et al. Role of immune system, apoptosis and angiogenesis in pathogenesis of rheumatoid arthritis and joint destruction, a systematic review. Tunis Med. 2007; 85(12): 991-998.

9. Марченко Ж С., Лукина Г.В. Роль сосудистого эндотелиального фактора роста в патогенезе ревматоидного артрита // Научно-практическая ревматология. 2005; 1: 57-60.

10. Clavel G., Boissier M.C. Angiogenesis Markers in Rheumatoid Arthritis. Future Rheumatol. 2008; 3(2): 153-159.

11. Machold K.P. Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease. Rheumatology (Oxford). 2007; 46: 342-349.

12. Porto L.S., Tavares Júnior W.C., Costa D.A. et al. Anti-CCP antibodies are not a marker of severity in established rheumatoid arthritis: a magnetic resonance imaging study. Rev. Bras. Reumatol. 2015; 14: S0482-5004(15)00124-2.

13. Murdaca G., Spanò F., Miglino M., Puppo F. Effects of TNF-[alpha]inhibitors upon the mechanisms of action of VEGF. Immunotherapy. 2013; 5(2): 113-115.

14. Hama M., Uehara T., Takase K. et al. Power Doppler ultra- sonography is useful for assessing disease activity and predicting joint destruction in rheumatoid arthritis patients receiving tocilizumab - preliminary data. Rheumatol. Int. 2012; 32(5): 1327-1333.

15. Malemud C.J. Growth hormone, VEGF and FGF: involvement in rheumatoid arthritis. Clin. Chim. Acta. 2007; 375: 10-19.


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