INTERACTOMICS IN TRANSLATIONAL MEDICINE
Abstract
The article describes the place of interactomics in translational medicine. The approaches and methods used for the detection of protein-protein interactions and the construction of interactomes are described. Examples of electronic databases that work with interactomes are given, as well as examples of consortia of such databases. Examples of the use of interactomes for developing new approaches and methods of treatment of such diseases as cancer, diabetes, schizophrenia are considered. The main difficulties encountered in the construction of interactomes, and the prospects for the development of interactomics are outlined.
About the Authors
A. I. Glukhov
I.M. Sechenov First Moscow State Medical University; Lomonosov Moscow State University
Russian Federation
Russian Federation
Z. A. Khuchua
I.M. Sechenov First Moscow State Medical University; Cincinnati Childrenʼs Hospital and Medical Center
Russian Federation
Russian Federation
G. K. Grizunova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
D. V. Astakhov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
M. I. Danilevskiy
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
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