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Modern drugs for obesity and metabolic syndrome treatment (Review)

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The article reviews modern anti-obesity drugs to identify new trends in effective and safe risk factors reduction (diabetes, cardiovascular and musculoskeletal diseases, cancer). Some anti-obesity drugs have a high risk of adverse effects on the CNS and cardiovascular system, so they should be used for a short-term therapy only. These drugs are cannabinoid receptor antagonists (Rimonabant), neuronal NE and 5-HT reuptake inhibitors (Sibutramine), neuronal NE, 5-HT, DA reuptake inhibitor (Tesofensine), 5HT2с receptors agonist (Lorcaserin) and other drugs affecting the central and peripheral mediator systems. That is why the treatment of obesity should focus on safe drugs that affected fat absorption (Orlistat), activated energy metabolism (Adipokines), methionine aminopeptidase 2 (MetAP2) inhibitors (Beloranib) etc. The combination of anti-obesity drugs with various mechanisms of action increases the effectiveness and reduces adverse effects (Contrave®, Empatic™, Qsymia etс).

About the Authors

M. L. Maximov
I.M. Sechenov First MSMU
Russian Federation

Maxim L. Maximov, Professor, the Department of clinical pharmacology and internal diseases propedeutics

13, Nikitsky Boulevard, Moscow, 121019

O. V. Dralova
I.M. Sechenov First MSMU
Russian Federation

Assistant professor, the Department of clinical pharmacology and internal diseases propedeutics


V. G. Kukes
I.M. Sechenov First MSMU
Russian Federation

Member of RAS, Head of the Department of clinical pharmacology and internal diseases propedeutics


V. N. Chubarev
I.M. Sechenov First MSMU
Russian Federation

Professor, the Department of clinical pharmacology and internal diseases propedeutics


V. V. Tarasov
I.M. Sechenov First MSMU
Russian Federation

Head of the innovative activity department, head of the Department of pharmacology, the Faculty of Pharmacology



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