Mucociliary system of the respiratory tract in children with asthma and allergic rhinitis
Abstract
Mucociliary system disturbances play a significant role in the pathogenesis of bronchopulmonary diseases. Preliminary results of our research concerning mucosiliary system functioning in children with asthma and allergic rhinitis are listed. Digital videocomplex was used to assess functioning of nasal ciliary epithelium. Our data suggest signifi cant structural and functional abnormalities of ciliary epithelium in asthma and allergic rhinitis.
About the Authors
I. V. Ozerskaya
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
post-graduate student of the the chair of childhood diseases
N. A. Geppe
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
Nataliya Anatolievna Geppe, MD, honoured doctor of Russia, director of the Research and educational clinical centre «Healthy Child», prof., head of the chair of childhood diseases
19 B. Pirogovskaya str., Moscow, 119435
8 (499) 248–64–79
U. S. Malyavina
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
PhD, doctor-otolaryngologist, head of the Otorhinolaryngology
department of children's diseases clinic, assistant lecturer of the chair of ear, nose and throat deseases
G. Chakroborti
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
PhD, lecturer of the the chair of childhood diseases
References
1. Chilvers M.A., Rutman A., O’Callaghan C. Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults // Thorax 2003; 58: 333–338.
2. Jorissen M., Willems T., Van der Schueren B. Nasal ciliary beat frequency is age independent // Laryngoscope. 1998. Jul; 108(7):1042-7.
3. Rutland J., Griffi n W.M., Cole P.J. Human ciliary beat frequency in epithelium from intrathoracic and extrathoracic airways // Am Rev Respir Dis. 1982. Jan; 125(1):100-5.
4. Yager J., Chen T.M., Dulfano M.J. Measurement of frequency of ciliary beats of human respiratory epithelium // Chest 1978; 73;627-633.
5. Bertrand B., Collet S., Eloy P., Rombaux P. Secondary ciliary dyskinesia in upper respiratory tract // Acta Otorhinolaryngol Belg. 2000; 54(3):309-16.
6. Liu Y.H., Tao Z.Z. Eff ect of intranasal glucocorticoid on the pathological change of nasal mucosa in rats with allergic rhinitis // Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Nov; 44(11): 935-40.
7. Maurizi M., Paludetti G., Todisco T. et al Ciliary ultrastructure and nasal mucociliary clearance in chronic and allergic rhinitis // Rhinology. 1984. Dec; 22(4): 233-240.
8. Yang P.C. Investigation of the nasal mucosa in perennial allergic rhinitis with SEM and TEM // Zhonghua Er Bi Yan Hou Ke Za Zhi. 1990; 25(2): 95-96, 126.
9. Kirtsreesakul V., Somjareonwattana P., Ruttanaphol S. The correlation between nasal symptom and mucociliary clearance in allergic rhinitis // Laryngoscope. 2009. Aug; 119(8): 1458-1462.
10. Oshyur L.Yu. Mucociliary clearance and bronchial permeability at standard basic therapy in patients with bronchial asthma. PhD diss. Blagoveschensk. 2004.
11. White S.R., Dorscheid D.R. Corticosteroid-Induced Apoptosis of Airway Epithelium // Chest. 2002; 122: 278- 284.
12. Zagorulko A.K., Askara T.A., Zagorulko A.A. et al. Integrated electron-microscopic evaluation of changes in the ultrastructure of the epithelium of the bronchial tubes in asthma in the experiment // Ukrainsky pulmonologichesky zhurnal. 2002. 2: 51–53.
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