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Dynamics of proinflammatory cytokines level in stable angina (II–III functional class)

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The article discusses the evaluation of cytokine level (IL-1β, IL-6) in patients with II–III functional class stable angina. In the group of patients with II–III class stable angina, the standard therapy failed to normalize the level of proinflammatory cytokines IL-1β and IL-6. In the group of patients with II–III class stable angina when the standard therapy combined with TES-therapy significantly reduced level of proinflammatory cytokines (IL-1β, IL6). TES-therapy decreases painful systemic inflammatory response more effectively than the standard therapy thus preventing damaging effect of proinflammatory cytokines. TES therapy produces a homeostatic effect, restores the balance of pro – and anti-inflammatory cytokines. We recommend to include TES-therapy in the standard treatment program in II–III class stable angina patients.

About the Authors

E. K. Gordeeva
Kuban State Medical University
Russian Federation

Elena Gordeeva, postgraduate student at the Department of General and Clinical Pathophysiology

4, Sedina str., Krasnodar, Russia, 350063

A. H. Kade
Kuban State Medical University
Russian Federation

Doctor of Medical Sciences, Professor, Head of the Department of General and Clinical Pathophysiology

S. A. Zanin
Kuban State Medical University
Russian Federation

Candidate of Medical Sciences, Аssistant Professor at the Department of General and Clinical Pathophysiology


1. Leshchinsky S.P. Geneticaqlly determined diseases, associated with increased risk of sudden cardiac death: ethiology, diagnosis and treatment. Sechenovskyi vestnik. 2014; 4(18): 34–40 (in Russian).

2. Drapkina O.M., Korneeva O.N., Deeva T.A. Epicardial fat as a new early marker of cardiovascular diseases in patients with non alcoholic fat liver disease. Sechenovskyi vestnik. 2014; 2(16): 32–37 (in Russian).

3. Oganov R.G. New opportunities to improve the quality and life expectancy of patients with stable coronary heart disease. Atmosphere. Cardiology News. 2015; 1: 11–14 (in Russian).

4. Chazov E.I. (ed.). Cardiology Manual in four volumes. Moscow: 2014; 2 (in Russian).

5. Lupach N.I., Hludeeva E.A., Potapov V.N., Lukyanov P.A. Matrix metalloproteinases, oxidative status and endothelial dysfunction in persons with hypercholesterolemia and patients with various forms of ischemic heart disease. Pacific Med. J. 2010; 4: 71–74 (in Russian).

6. Kozlovsky V.I., Akulenok A.V. The role of leukocytes activation in endothelial damage and cardiovascular diseases. Bulletin VSMU. 2005; 4(2): 5–13 (in Russian).

7. Belov Y.V., Litvitsky P.F., Vinokourov I.A. Acute renal failure in cardiac surgery practice: predictors, mechanisms of development and diagnostic criteria. Sechenovskiy Vestnik. 2015. 4(22): 4–11 (in Russian).

8. Pavlov O.N. The association between inflammation and the increase in antibody titer to the helicobacter pylori in acute coronary syndrome. Cardiology J. 2011; 6(92): 43–46 (in Russian).

9. Sukhija R. et al. Inflammatory markers, angiographic severity of coronary artery disease, and patient outcome. Am. J. Cardiol. 2007; 99(7): 879–884.

10. Ragino Y.I. et al. The activity of inflammatory and destructive changes in the formation of unstable atherosclerotic plaque. Cardiology. 2007; 9: 62–67 (in Russian).

11. Kovalchuk L.V. et al. Clinical Immunology and Allergology with the basics of Immunology. Moscow: GEOTARMedia; 2014: 640 (in Russian).

12. Zakirova N.E., Hafizov N.H., Zakirova A.N. Immunological and inflammatory reactions in coronary heart disease patients. Ratsionalnaya farmakopia in kardiology (Rational pharmacotherapy in cardiology). 2007; 2: 16–19 (in Russian).

13. Krishnamurthy P., Rajasingh J., Lambers E. et al. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT-3 and suppression of HuR. Circ Res. 2009; 104: 9–18.

14. Kofler S., Nickel T., Weis M. Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clinical Science. 2005; 108: 205–213.

15. Nazheva M.I., Demidov I.A. Diagnostic value of C-reactive protein and interleukin-6 blood basic concentrations for cardiovascular risk assessment. Meditsinkyi vestnik Yuga Rossii (Medical bulletin of the South Russia). 2015; 3: 86–91 (in Russian).


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