Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review)
Abstract
Development of pharmaceuticals on the basis of zinc complexes containing imidazoles as ligand systems appears promising. High activity and a wide range of pharmacological effects of such compounds result from zinc biological role as n essential trace element, and zinc bioavailability with imidazol cycles in the complex structure. The article reviews the molecular mechanisms of zinc homeostasis. The article analyzes the literary data and the data of our studies and discusses the application of zinc complexes with N-alkenylimidazole in medicine on the example of Acyzol.
About the Authors
S. A. Shakhmardanova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Swetlana Shakhmardanova, Candidate of Biological Sciences, Associate Professor at the Department of Pharmacology
13/1, Nikitsky Boulevard, Moscow, Russia, 121019
P. A. Galenko-Yaroshevsky
Kuban State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Department of Pharmacology
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