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The relationship between the parameters of microcirculation and the lung function in bronchial asthma in children

https://doi.org/ 10.47093/2218-7332_2018.3.30-35

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Abstract

Among the chronic nonspecific lung diseases, bronchial asthma (BA) takes the leading place. BA in children is primarily diagnosed on the basis of clinical manifestations, methods of functional diagnosis, which allows you to verify the disease and assess the severity of the flow. An important role in the pathogenesis of asthma is played by the microcirculation system, affecting the course and progression of the disease. Dysfunction of microcirculation system supports chronic inflammatory process, affecting the level of perfusion, metabolism and gas exchange. The study was carried out on the basis of the University Children's Clinical Hospital (pulmonology department) of the First Moscow State Medical University named after I.M. Sechenov Ministry of Health of Russia (Sechenovsky University). 100 children aged 6-17 years with asthma were examined. Based on the study of the nature of microcirculatory disorders by the LDF method in bronchial asthma in children with different severity of the disease, correlation links between microcirculation indices, clinical manifestations and external respiration function (spirometry and computer bronchophonography) in children have been revealed. The observed decrease in microcirculation during the exacerbation of asthma is short-term and insignificant in mild severity and is longer and more significant with moderate BA, which supports a chronic inflammatory process in the bronchi. Correction of disorders of microcirculation is an important link in the therapeutic approach.

About the Authors

N. I. Lozko
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


N. G. Kolosova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


N. A. Geppe
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


V. D. Denisova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation


References

1. Beydon N, Davis S.D, Lombardi E et al. An official American Thoracic Society. European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007; 175 (12): 1304-45.

2. Национальная программа «Бронхиальная астма у детей. Стратегия лечения и профилактика». Изд. 5-е, перераб., доп. М.: Оригинал - макет, 2017.

3. Papadopoulos N.G, Arakawa H, Carlsen K.H et al. International consensus on (ICON) pediatric asthma. Allergy 2012; 67 (8): 976-97.

4. Akinbami O.J. Asthma prevalence, health care use, and mortality: United States, 2005-2009. Washington, DC: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, 2011; p. 1-14.

5. GINA Report 2018, Global Strategy for Asthma Management and Prevention. http://ginasthma.org/2018-gina-report-global-strategy-for-asthma-management-and-prevention/

6. Ходюшина И.Н., Урясьев О.М. Изменения показателей гемодинамики у больных бронхиальной астмой. Рос. Медико - биологический вестн. им. акад. И.П.Павлова. 2011; 2: 1-11.

7. Геппе Н.А., Колосова Н.Г., Герасимов А.Н. и др. Возрастные параметры нормы компьютерной капилляроскопии и лазерной допплеровской флоуметрии. Вопр. практической педиатрии. 2018; 13 (1): 40-4.

8. Геппе Н.А., Малышев В.С. Компьютерная бронхофонография респираторного цикла. М.: Медиа Сфера, 2016.

9. Крупаткин А.И., Сидоров В.В. Функциональная диагностика состояния микроциркуляторно - тканевых систем. Колебания, информация, нелинейность. Руководство для врачей. М., 2013.

10. Глазова Т.Г. и др. Изменения свойств тромбоцитов и показателей гемостаза при персистирующем течении бронхиальной астмы у детей. Казан. мед. журн. 2011; 92 (4): 566-8.

11. Тихонова И.В., Косякова Н.И., Танканаг А.В., Чемерис Н.К. Влияние обструкции верхних дыхательных путей на микроциркуляцию кожи у больных бронхиальной астмой. Вестник РАМН. 2016; 71 (3): 233-9.


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)