Epicardial fat as a new early marker of cardiovascular disease in patients with non-alcoholic fatty liver disease
Abstract
Excess visceral obesity is considered the hallmark of the metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD), which in the modern view is regarded as one of the criteria for MS. Epicardial fat (PE) is involved in the pathogenesis of atherosclerosis in coronary vessels. The purpose of this study is evaluation of patients with MS and NAFLD epicardial fat thickness values by echocardiography and their association with 1) the clinical and metabolic changes, 2) the initial manifestation of atherosclerotic lesions of the vascular bed, according to the thickness of the intima-media complex. In our study patients with MS and NAFLD had higher values of the thickness of the epicardial fat than the control group. Increase in the layer of epicardial fat was associated with insulin resistance and manifestations of remodeling of the vascular wall, endothelial dysfunction, dyslipidemia, impaired left ventricular diastolic function.
About the Authors
O. M. Drapkina
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
Oksana Mikhailovna Drapkina, MD, prof. of the chair of propaedeutics of internal diseases, deputy director of the Centre for Innovative Therapy of the Research Centre
8–1 Trubetskaya str., Moscow, 119435
8 (499) 248–75–15
O. N. Korneeva
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
senior researcher of the Research Department of Innovative Therapy
T. A. Deeva
I.M. Sechenov First MSMU
Russian Federation
Russian Federation
clinical intern of the chair of propaedeutics of internal diseases
References
1. Kannel W.B. Sixty years of preventive cardiology: a framingham perspective // Clin. Cardiol. 2011; 34 (6): 342–343.
2. Ivashkin V.T., Drapkina O.M., Korneeva O.N. Clinical variants of metabolic syndrome. M. «MIA». 2011.
3. The IDF consensus worldwide defi nition of the metabolic syndrome.http://www.idf.org/webdata/docs/Metac_syndrome_def.pdf. 2005; 2006.
4. Chumakova G.A., Veselovskaya N.G., Gritsenko O.V., Vakhromeeva E.V., Subbotin E.A. Epicardial obesity as a possible marker of the metabolic syndrome // Kardiosomatika. 2012; 4: 51–54.
5. Drapkina O.M., Korneeva O.N., Chernova E.M. Epicardial fat and non-alcoholic fatty liver disease // Rossij skie meditsinskie vesti. 2013; XVIII (2): 50.
6. Drapkina O.M. Components of the metabolic syndrome: focus on non-alcoholic fatty liver disease // Spravochnik poliklinicheskogo vracha. 2009; 10: 64–67.
7. Perseghin G., 2009, EASL Congress abstracts, p. 36.
8. Iacobellis G., Willens H.J. Echocardiographic Epicardial Fat: A Review of Research and Clinical Applications // JASE 2009; 22 (12): 1311–1319.
9. Bellentani S., 2009, EASL Congress abstracts, p. 26–27.
10. El–Serag H., 2009, EASL Congress abstracts, p. 28.
11. Perseghin G., 2009, EASL Congress abstracts, p. 36.
12. Machado M., Marques-Vidal P., Cortez-Pinto H. Hepatic histology in patients undergoing bariatric surgery // J. Hepatol. 2006; 45: 600–606.
13. Grinevich V.B., Sas E.I. Nonalcoholic fatty liver disease: clinical and social aspects of the problem // Rossij skie meditsinskie vesti. 2010; 1: 39–46.
14. Juge-Aubry C.E., Henrichot E., Meier C.A. Adipose tissue: a regulator of infl ammation // Best Pract. Res. Clin. Endocrinol. Metab. 2005; 19 (4): 547–566.
15. Brook R.D. Obesity, weight loss, and vascular function // Endocrine 2006; 29 (1): 21–25.
16. Mazurek T., Zhang L., Zalewski A., Mannion J.D., Diehl J.T., Arafat H., Sarov L., O'Brien S., Keiper E.A., Johnson A.G., Martin J., Goldstein B.J., Shi Y. Human epicardial adipose tissue is a source of infl ammatory mediators // Circulation. 108 (2003): 2460–2466.
17. Iacobellis G., Assael F., Ribaudo M.C. et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction // Obes. Res. 2003; 11: 304–310.
18. Sobhonslidsuk A., Jongjirasiri S., Thakkinstian A., Wisedopas N., Bunnag P., Puavilai G. Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis // World J. Gastroenterol. 2007 July 14; 13(26): 3614–3618.
19. Ostroumova O.D., Zhukova O.V., Erofeeva A.G., Otdelenov A.V. The thickness of the intima-media of the carotid arteries in patients with hypertension — opportunities for fi xed combination Logimaks // RMZh. 2009. № 8.
20. Burke G.L., Evans G.W., Riley W.A. et al. Arterial wall thickness is associated with prevalent cardiovascular diseases in middle–aged adults. The Atherosclerosis Risk in Communities (ARIC) study // Stroke. 1995; 26: 386–391.
21. Bots M.L., Hoes A.W., Koudstaal P.J. et al. Common carotid intima-media thickness and risk of stroke and myocardial infarction. The Rotterdam Study // Circulation. 1997; 96: 1432–1437.
22. Riding E. Echocardiography. A practical guide. M. «MEDpress-inform». 2012. P. 54–55.
23. Tkachenko S.B., Beresten’ N.F. Tissue Doppler myocard research. M. Real Time. 2006. P. 35–60.
24. Nagvi T.Z. Diastolic function assrssment incorporating new technigues in Doppler Echocardiography // Rev. Cardiovascular medicine 2003; 2:4, 81–99.
25. Tselujko V.I., Radchenko O.V., Kinoshenko K.Yu. Diastolic function of the left ventricle in patients with metabolic syndrome X.
26. Shlyakhto E.V., Konradi A.O., Zakharov D.V., Rudomanov O.G. Structural and functional changes in the myocardium in patients with hypertension // Kardiologiya. 1999; 2: 49–55.
27. Agabiti-Rosei E., Muiesan M.L. Hypertension and diastolic function // Drugs. 1993; 46: 61–67.
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