THE DEVELOPMENT AND VALIDATION OF METHODS FOR QUANTITATIVE DETERMINATION OF THIAMINE IN BLOOD PLASMA BY MEANS OF LC-MS METHOD PROVIDING STUDIES OF BIOEQUIVALENCE
Abstract
The methods for quantitative determination of thiamine in blood plasma by means of LC-MS method providing studies of bioequivalence are developed in this paper.
About the Authors
O. A. Tashirova
Institute of immunology of FMBA of RF
Russian Federation
Russian Federation
O.A. Tashirova, PhD, researcher
V. V. Smirnov
First MSMU named after I.M. Sechenov
Russian Federation
Russian Federation
V.V. Smirnov, PhD, senior lecturer of the chair of pharmaceutical and toxicological chemistry
A. M. Vlasov
First MSMU named after I.M. Sechenov
Russian Federation
Russian Federation
A.M. Vlasov, PhD, associate prof. of the chair of pharmaceutical and toxicological chemistry
M. R. Haitov
Institute of immunology of FMBA of RF
Russian Federation
Russian Federation
M.R. Haitov, PhD, researcher
G. V. Ramenskaya
First MSMU named after I.M. Sechenov
Russian Federation
Russian Federation
G.V. Ramenskaya, Doctor of pharmacy, prof., head of the chair of pharmaceutical and toxicological chemistry, director of the Research institute of pharmacy
References
1. Singleton C.K., Martin P.R. Molecular mechanisms of thiamine utilization // Curr. Mol. Med. — 2001. — Vol. 1. — № 2. — P. 197–207.
2. Спиричев В.Б. Витамины, витаминоподобные и минеральные вещества. Справочник для провизоров и фармацевтов. — М., 2005. — 239 с.
3. Конь И.Я., Тоболева М.А., Димитриева С.А. Дефицит витаминов у детей: основные причины, формы и пути профилактики у детей раннего и дошкольного возраста // Вопр. современной педиатрии. — 2002. — Т. 1. — № 2. — С. 62–66.
4. Ярош А.К. Сравнительная фармакокинетика препаратов витамина В<sub>1</sub> (тиамина) и их фармакодинамическая (лечебная) эффективность // Ліки України: Науковий журнал. — 2009. — № 7(133). — С. 71–76.
5. Volvert M.L., Seyen S., Piette M. et al. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipidsoluble thiamine disulfide derivatives // Posted. — 2008. — Vol. 11. — Р. 19.
6. Wada T., Takagi H., Minakami H. et al. A new thiamine derivate, S-benzoylthiamine O-monophosphate // Scien. — 1961. — Vol. 134. — P. 195–196.
7. Fujiwara M., Watanabe H., Matsui K. Allithiamine a newly found derivate of vitamin B1. I. Discovery of Allithiamine // J. Biochem. — 1954. — Vol. 41. — P. 29–39.
8. Baker H., Frank O. Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines // J. Nutr. Sc. Vitaminol. — 1976. — Vol. 22. — P. 63–68.
9. Geissler C., Powers H. Human Nutrition. — Edinburgh, 2006. — 763 p.
10. Davis R.E. Clinical chemistry of thiamine // Adv. Clin. Chem. — 1983. — Vol. 23. — P. 93–140.
Review
Views:
227
Email this article 